Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection ComplicationsCOVID-19 병인 및 감염 후 합병증에서 Annexin A2의 가능한 역할에 대한 분자적 통찰력Review Published on 2021-10-132022-09-10 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] addition Annexin Annexin A2 Antiviral AnxA2 clinically Complication complications Continuous COVID-19 cytokine Cytokine storm develop docking effective drug effective drugs effort Evidence glycoprotein in silico individual Infection insight insulin insulin resistance interactions internalization knowledge lack management molecular molecular mechanism molecular mechanisms mutated outbreak Pathogenesis performed Post-infection Prophylactic Protein provide Replication respiratory RNA-dependent RNA polymerase role SARS-CoV-2 SARS-CoV-2 pathogenesis Severe acute respiratory syndrome spike glycoprotein the SARS-CoV-2 thrombosis treat Vaccine Viral viral infection viral pathogenesis viral spike [DOI] 10.3390/ijms222011028 PMC 바로가기 [Article Type] Review
SARS-CoV-2 transgressing LncRNAs uncovers the known unknownsLncRNA를 횡단하는 SARS-CoV-2는 알려진 미지의 것을 밝힙니다.Editorial Published on 2021-10-012022-09-11 Journal: Physiological Genomics [Category] SARS, 유전자 메커니즘, [키워드] asked disease pathogenesis endocytosis functional Functional genomics Host host pathogenesis hypothetical lncRNA lncRNAs long noncoding RNA mechanism molecules Open reading frame ORFs Pathogenesis Pathways Perspective Region regulate Regulatory SARS-CoV-2 SARS-CoV-2 pathogenesis the disease transgression. viral infection viral pathogenesis Viral protein Viral proteins [DOI] 10.1152/physiolgenomics.00075.2021 PMC 바로가기 [Article Type] Editorial
Characterization and structural basis of a lethal mouse-adapted SARS-CoV-2치명적인 마우스 적응 SARS-CoV-2의 특성 및 구조적 기초Article Published on 2021-09-272022-09-10 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] ACE2 adaptation age Amino acid amino acid substitutions Analysis animal hosts animal model animal models binding affinity cause characterization complex cryo decrease deep deep sequencing ENhance Evolution exhibit generate hACE2 human ACE2 in vivo K417N mACE2 Microscopy molecular basis molecular mechanism Mortality mouse-adapted SARS-CoV-2 Mutation N501Y pathogenicity Pathogens platform provide RBD RBD mutation receptor Receptor binding domain reduce respiratory respiratory symptoms reveal SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 strain Sequencing severe COVID-19 severe respiratory symptoms significantly structural biology the binding affinity the RBD virus Virus-host interactions [DOI] 10.1038/s41467-021-25903-x PMC 바로가기 [Article Type] Article
SARS-CoV-2 Subgenomic RNAs: Characterization, Utility, and PerspectivesSARS-COV-2 Subgenomic RNA : 특성화, 유용성 및 관점Review Published on 2021-09-242022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] characterization Comprehensive COVID-19 COVID-19 pandemic etiologic agent marker Research RNA RNA genome root SARS-CoV-2 SARS-CoV-2 pathogenesis sgRNA sgRNAs subgenomic RNA subgenomic RNAs Viral viral replication [DOI] 10.3390/v13101923 PMC 바로가기 [Article Type] Review
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice마우스에서 SARS-CoV-2 발병에 대한 렘데시비르의 경구 뉴클레오시드 유사체의 치료 효능Article Published on 2021-09-172022-09-11 Journal: bioRxiv [Category] 비임상, [키워드] administration Antiviral antiviral activity antivirals Breakthrough infection breakthrough infections breath conserved COVID-19 COVID-19 pandemic Culture develop dose-dependent drug effective Efficacy exhibited exploration GS-441524 human clinical trial humans IMPROVE in vitro in vivo increasingly infected with SARS-CoV-2 Infection lung cell lung cell line lung cell lines Lung pathology mice molnupiravir monoclonal antibodies monoclonal antibody nucleoside oral administration outcome outpatients parental pharmacokinetic Pulmonary function reduced Remdesivir RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants significantly Support target therapeutic therapeutic efficacy therapy These data translated Treatment uncontrolled vaccination Viral load Viral protein Viral proteins waning immunity [DOI] 10.1101/2021.09.13.460111 PMC 바로가기 [Article Type] Article
Computational Methods to Study Human Transcript Variants in COVID-19 Infected Lung Cancer CellsCOVID-19에 감염된 폐암 세포에서 인간 전사체 변이체를 연구하기 위한 전산 방법Article Published on 2021-09-072022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] 3′-UTR A549 addition Alter alternative polyadenylation alternative splicing Analysis APA applied biological pathway cells Combination computational method Computational methods correlation COVID-19 COVID-19 pandemic Data analysis detect Differential gene expression differential gene expression analysis differentially expressed event events host transcriptome Human indicate Infection lab lead lung alveolar microbes mock-treated molecular molecular mechanism pathway Pathways Regulation Research RNA-Seq RNA-seq data SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 infected cells SARS-CoV-2 pathogenesis the disease transcript transcript variants Transcriptome transcriptomes variant virus viruses [DOI] 10.3390/ijms22189684 PMC 바로가기 [Article Type] Article
Similar antibody responses against SARS-CoV-2 in HIV uninfected and infected individuals on antiretroviral therapy during the first South African infection wave남아프리카 공화국의 첫 번째 감염 물결 동안 항레트로바이러스 요법을 받은 HIV 감염되지 않은 개인과 감염된 개인에서 SARS-CoV-2에 대한 유사한 항체 반응Major Article Published on 2021-09-022022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] addition African age anti-SARS-CoV-2 IgM antibodies antibody antibody immunity Antibody Response Antibody titer Antiretroviral therapy ART B cell response binding characterized circulating Comorbidity comparable Complete convalescent plasma COVID-19 COVID-19 vaccine Diagnosis effective First wave flow cytometry Frequency groups HIV IgA IgA antibody IgG IgM in both groups infected individual Infection Infectious disease Live virus Loss magnitude natural infection neutralization Neutralization assay neutralization potency PLWH Population potency provide Result SARS-CoV-2 SARS-CoV-2 infected individual SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 receptor secreting cell seroconversion rates significantly South South Africa sub-Saharan Africa uninfected was determined with HIV [DOI] 10.1093/cid/ciab758 PMC 바로가기 [Article Type] Major Article
Sensitive detection of anti-spike antibodies enables improved understanding of SARS-CoV-2 pathogenesis스파이크 방지 항체의 민감한 검출을 통해 SARS-CoV-2 병인에 대한 이해 향상Editorial Published on 2021-09-012022-09-11 Journal: Immunology [Category] SARS, 진단, 치료기술, [키워드] active infections anti-spike antibody Anti-viral immune response anti-viral immune responses antibody complement detect ELISA help immune response immune responses immunological protection Infection infections isotype likelihood mass mass vaccination natural infection pandemic positive result predict provide re-infected Saliva SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2-specific antibodies SARS-CoV-2-specific antibody sensitive serum specific antibodies spike glycoprotein Test tide turn vaccination Vaccinations Viral viral infection viral infections Viral RNA virus [DOI] 10.1111/imm.13399 PMC 바로가기 [Article Type] Editorial
SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte eliminationSARS-CoV-2 스파이크 단백질은 합포체 매개 림프구 제거를 지시합니다Article Published on 2021-09-012022-09-11 Journal: Cell Death and Differentiation [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-viral drug Anti-viral drugs cause cells cellular cellular structure contagious coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 therapy death expression identify induce inhibit lung tissue lung tissues lymphocyte Lymphocytes lymphocytopenia mechanism membrane fusion molecular motif patients polybasic prevalent respiratory S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 spike glycoprotein SARS-CoV-2 spike protein severe acute respiratory syndrome Coronavirus spike glycoprotein Structure structures Surface glycoprotein Syncytia syncytium target the SARS-CoV-2 therapy unique virus viruses [DOI] 10.1038/s41418-021-00782-3 PMC 바로가기 [Article Type] Article
Potential Immunomodulatory Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-CoronavirusesSARS-CoV-2 및 Pan β-Coronavirus에 대한 향신료의 생물학적 활성 성분의 잠재적 면역 조절 특성Cellular and Infection Microbiology Published on 2021-08-272022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 치료제, [키워드] activity Acute respiratory failure acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Against alleviate Anti-inflammatory antioxidant antioxidants Antiviral antiviral properties bioactive components CCL2 cellular pathway cellular pathways chemokine Clinical outcome component contributing to coronavirus COVID-19 COVID-19 severity diet Effect elevated erythroid Health Health crisis Health Organization highlight HMOX1 homeostasis host cell host cell factor Host immune response host immune responses hypercytokinemia hyperinflammation IL6 IL8 immune responses Immunity inhibiting Interleukins lethality mediators modulate Multiorgan dysfunction Nrf2 nuclear oxidative oxidative stress Pan pathway Pneumonia Potential Prevent pro-inflammatory pro-inflammatory mediator pro-inflammatory mediators promise property PROTECT protective immunity respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus spice spices sustained systemic inflammation tissue damage TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-alpha Variation World Health Organization β-Coronaviruses [DOI] 10.3389/fcimb.2021.729622 PMC 바로가기 [Article Type] Cellular and Infection Microbiology