Metabolomics-based investigation of SARS-CoV-2 vaccination (Sinovac) reveals an immune-dependent metabolite biomarkerArticle Published on 2022-09-282022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] analyses Analysis antibodies and cytokines antibody association AUC Biomarker boost butanoate collected COVID-19 COVID-19 vaccine Cytokines determine effective fatality FDR Fold change GABA Glutamate greater help Host host immunity IgA IgG IgM immune Immunity IMPROVE individual indole Infection L-glutamic acid metabolism metabolite metabolome metabolomic metabolomic analysis metabolomics mutant strain mutated Pathways positive pre-vaccination provide respond reveal SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 virus infection sera serum serum antibody Sinovac Spread Taurine vaccination Vaccine VIP Volunteer was performed [DOI] 10.3389/fimmu.2022.954801 PMC 바로가기
Serum biomarkers associated with SARS-CoV-2 severityArticle Published on 2022-09-262022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] acute phase Angiogenesis Asymptomatic biological marker Biomarker cardiovascular diseases chemokine Clinical course controls correlated cytokine D-dimer disease disease severity elevated evaluated Factor group groups Growth factors help Hospitalized identify immune response individual infected with SARS-CoV-2 Infection Mild negative control Patient patients with SARS-CoV-2 prognostic Prognostic markers RT-PCR SARS-CoV-2 SARS-COV-2 infection sera Severe case severity [DOI] 10.1038/s41598-022-20062-5 PMC 바로가기
Comparative analysis of the neutralizing activity against SARS-CoV-2 Wuhan-Hu-1 strain and variants of concern: Performance evaluation of a pseudovirus-based neutralization assayArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] Ad26.COV2.S Affect analyzed anti-SARS-CoV-2 AZD1222 B.1.1.529 B.1.617.2 booster dose booster vaccination BSL-2 collected Comparative analysis condition controls convalescent correlated COVID-19 Delta Efficacy elicited emergence gold standard help helping Immune status immunogenicity individual Infection live viruses management MNT mRNA mRNA-1273 NAb neutralization neutralization activity Neutralization assay neutralize Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody omicron performance pseudotyped Pseudotyped virus receiving reduced reduction reliability SARS-CoV-2 SARS-CoV-2 spike protein second dose sera strain vaccination Vaccination strategies Vaccine vaccinee Vaccines variant variants of concern variants of SARS-CoV-2 Viral vector virus VoC VOCs were used wild type WT strain Wuhan-Hu-1 [DOI] 10.3389/fimmu.2022.981693 PMC 바로가기
The Receptor Binding Domain of SARS-CoV-2 Lambda Variant Has a Better Chance Than the Delta Variant in Evading BNT162b2 COVID-19 mRNA Vaccine-Induced Humoral ImmunityArticle Published on 2022-09-262022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, [키워드] ACE2 ACE2 binding amino acid changes antibody bamlanivimab Better bind binding BNT162b2 BNT162b2 mRNA BNT162b2 vaccine chance COVID-19 Delta delta variant dropped evaluate the effect human Angiotensin-converting enzyme immunized individual L452R Lambda less Ligand mRNA Mutation mutations Protective protective effect RBD Receptor binding domain SARS-CoV-2 sera serum antibody serum antibody. T478K the RBD titer vaccinated individual vaccination Vaccine variant variants of concern variants of interest VoC WHO wild type World Health Organization [DOI] 10.3390/ijms231911325 PMC 바로가기
Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South KoreaArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] baseline BNT BNT162b2 ChAdOx1 cohort study collected comparable conducted convalescent COVID-19 patients convalescent sera correlation COVID-19 COVID-19 pandemic COVID-19 vaccination cumulative Decreased Delta delta variant dose estimation explain groups HCW HCWs healthcare worker Heterologous highest homologous IQR Kinetics median Neutralizing neutralizing antibody Neutralizing antibody titer outbreak performed PRNT Protective protective immunity protocol SARS-CoV-2 sera serum sample significantly higher South Korea the mean vaccination Vaccine development variants of concern VoC VOCs was used wild type wild-type SARS-CoV-2 WT SARS-CoV-2 [DOI] 10.3389/fimmu.2022.968105 PMC 바로가기
Kynurenine serves as useful biomarker in acute, Long- and Post-COVID-19 diagnosticsArticle Published on 2022-09-232022-11-15 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] Admission age Biomarker Blood Concentration concerning controls correlated COVID-19 COVID-19 monitoring CRP CRP value diagnosis and monitoring diagnostics disease Donor elevated group hospital Hospitalized hyperinflammation IL-6 immune system Inflammation inflammation diagnostics Inflammatory Inflammatory marker Inflammatory response innate immune response Innate immunity Inpatient interleukin-6 investigated involved Kynurenine kynurenine reference values. Long Long-COVID biomarkers long-lasting marker material P-value pathophysiology Patient patients with SARS-CoV-2 rehabilitation Saliva SARS-COV-2 infection sera serum significantly significantly higher subset Symptom syndrome the SARS-CoV-2 therapy were measured [DOI] 10.3389/fimmu.2022.1004545 PMC 바로가기
Intranasal immunization with recombinant Vaccinia virus encoding trimeric SARS-CoV-2 spike receptor-binding domain induces neutralizing antibodyArticle Published on 2022-09-222022-11-15 Journal: Vaccine [Category] SARS, 진단, 치료기술, [키워드] BALB/c mice Bronchoalveolar lavage fluid cellular immune responses COVID-19 detectable dissemination domain Effects elicited evaluated exhibited expressing humoral IgA IgG immune response immunization immunized induce Infection intranasal Lymphocytes mice mucosal mucosal immune nasal washe neutralization neutralization activities Neutralizing Neutralizing antibodies neutralizing antibody RBD respiratory response robust SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein secretory IgA sera systemic immune response transmission of SARS-CoV-2 trimeric trimeric RBD Vaccine vaccinia vaccinia virus virus [DOI] 10.1016/j.vaccine.2022.08.054 PMC 바로가기
Diagnostic performance of molecular and serological tests of SARS-CoV-2 on well-characterised specimens from COVID-19 individuals: The EDCTP “PERFECT-study” protocol (RIA2020EF-3000)Article Published on 2022-09-212022-11-15 Journal: PLoS ONE [Category] SARS, 변종, 치료기술, [키워드] affecting Amplicon assays Biorepository Care Clinical diagnosis Clinicians collected conducted confirmed case contribute COVID-19 COVID-19 infection creating diagnosing Diagnosis effective effort ELISA ENhance Epidemiology evaluated Evidence facilitate Fatality rate Follow-up Genetic identify IMPROVE individual individuals management measure molecular Molecular assay molecular assays PCR performed platform point-of-care positive protocol real-time qPCR risk SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV2 sera Serological assay serological test Serological testing specificity specimen strain Swab transfer translate Treatment well [DOI] 10.1371/journal.pone.0273818 PMC 바로가기
Baculovirus-Free SARS-CoV-2 Virus-like Particle Production in Insect Cells for Rapid Neutralization AssessmentArticle Published on 2022-09-202022-11-15 Journal: Viruses [Category] SARS, 진단, [키워드] ACE2 Analysis antibodies antibody approach assays assessment binding candidate Cell cellular cellular assay donors enzyme evaluate expression expression plasmid expression vector flow cytometric fluorescent fusion genomic information GFP insect insect cell insect cells labeling membrane membrane protein monoclonal antibody NTA Particle plasmid transfection Production purification quantification Rapid required SARS-CoV-2 SARS-CoV-2 envelope secondary antibody sera Spike protein TEM therapeutic transmission electron microscopy vaccinated individuals virus Virus-like particle Virus-like particles (VLPs) VLP VLPs [DOI] 10.3390/v14102087 PMC 바로가기
Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cellsArticle Published on 2022-09-162022-11-15 Journal: Scientific Reports [Category] SARS, 진단, [키워드] ACE2-positive cell addition ADE ADE activity adverse effect anti-SARS-CoV-2 antibody Antibody-dependent enhancement Antisera approved caused collected concentrations COVID-19 pandemic examined exhibited FcR in vivo individual Infection inoculated mAb mAbs monoclonal mRNA vaccines Neutralizing Neutralizing activity omicron S-protein SARS-CoV-2 spike protein sera therapeutic therapeutic effect [DOI] 10.1038/s41598-022-19993-w PMC 바로가기