Hydrogen Sulfide Inhibits TMPRSS2 in Human Airway Epithelial Cells: Implications for SARS-CoV-2 InfectionArticle Published on 2021-09-202022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] ACE2 ACE2 expression activities affected airway epithelial cell airway epithelial cells angiotensin-converting enzyme 2 Anti-inflammatory Anti-viral cell line cell type compounds conditions COVID-19 pandemic deaths Effect expression Host Human hydrogen Hydrogen sulfide in vitro infect Inhaled Lower respiratory tract lung organism Prevent produced protease Protective reduce respiratory epithelial cell Respiratory system Result SARS-CoV-2 SARS-CoV-2 entry serine 2 shown significantly surface protein target cells targets tested therapeutic strategy therapy TMPRSS2 transmembrane vaccination virus [DOI] 10.3390/biomedicines9091273 PMC 바로가기 [Article Type] Article
The inhibitory effects of toothpaste and mouthwash ingredients on the interaction between the SARS-CoV-2 spike protein and ACE2, and the protease activity of TMPRSS2 in vitroSARS-COV-2 스파이크 단백질과 ACE2 사이의 상호 작용에 대한 치약 및 구강 세척 성분의 억제 효과 및 시험 관내 TMPRSS2의 프로테아제 활성.Research Article Published on 2021-09-172022-09-10 Journal: PLoS ONE [Category] SARS, 진단, 치료기술, [키워드] ACE2 angiotensin angiotensin-converting enzyme 2 binding cleaved copper copper gluconate docking evaluated expressed help Host host cell host cells in vitro ingredient inhibitory effect Inhibitory effects Interaction mouthwashe mouthwashes mucosa oral cavity Prevent protease Protease activity SARS-CoV-2 SARS-COV-2 infection Serine serine 2 sodium sodium dodecyl sulfate sodium N-lauroylsarcosinate Spike protein suggested sulfate the SARS-CoV-2 TMPRSS2 TMPRSS2 protease tongue tranexamic acid transmembrane transmembrane protease serine 2 Viral viral spike protein [DOI] 10.1371/journal.pone.0257705 PMC 바로가기 [Article Type] Research Article
Management of Patients With Glucocorticoid-Related Diseases and COVID-19글루코코르티코이드 관련 질환 및 COVID-19 환자 관리Review Published on 2021-09-142022-09-11 Journal: Frontiers in Endocrinology [Category] MERS, SARS, 유전자 메커니즘, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus addition administration Adrenal insufficiency adrenocortical carcinoma affecting angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anticancer binding Cancer caused circulating cleaved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CTSB CTSL Cushing’s syndrome cushing’s syndrome cytokine Cytokine storm Endocrine enzyme expressed furin gastrointestinal tract genes encoding glucocorticoid Glucocorticoids group Health Health crisis host cell host cells hyperaldosteronism immune response Immunosuppressant immunosuppressants immunosuppressive in silico analysis Infection inhibitory effect kidney lung management mRNA expression outcome pandemic pathophysiological mechanism Patient Pituitary protease respiratory SARS-CoV-2 secreted Serine serine 2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 susceptibility the cytokine storm the timing tissues TMPRSS2 transmembrane transmembrane protease serine 2 Tumor tumors [DOI] 10.3389/fendo.2021.705214 PMC 바로가기 [Article Type] Review
Effects of endurance training on the expression of host proteins involved in SARS‐CoV‐2 cell entry in C57BL/6J mouseOriginal Article Published on 2021-09-142022-10-28 Journal: Physiological Reports [Category] COVID-19, SARS, [키워드] acute respiratory syndrome binding caused cell entry changes in Colon coronavirus coronavirus disease COVID‐19 COVID‐19 Effect endurance endurance exercise endurance training enzyme expression form Health help Host host cell membranes host protease host protein host receptor Host receptors increased risk infect Intervention investigated involved kidney liver lung mice mouse organ pandemic physical activity priming promote protease Proteins question SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 serine 2 tissue TMPRSS2 transmembrane were measured [DOI] 10.14814/phy2.15014 PMC 바로가기 [Article Type] Original Article
Testosterone in COVID-19: An Adversary Bane or Comrade BoonCellular and Infection Microbiology Published on 2021-09-082022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, MERS, SARS, [키워드] activating acute lung injury acute respiratory distress acute SARS-CoV-2 infection addition Affect anti-inflammatory cytokines ARDS article caused cleaving COVID-19 COVID-19 severity Direct Effect Endothelial dysfunction Google Scholar immune response Injury manifestation modulation MOST oxidative stress pandemic disease pro-inflammatory cytokines protease Respiratory Coronavirus SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike protein Science serine 2 severity of COVID-19 syndrome Testosterone TMPRSS2 TMPRSS2 transmembrane was done Web of Science [DOI] 10.3389/fcimb.2021.666987 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2중증 급성 호흡기 증후군 코로나바이러스 2에 의한 기간 태반 감염에 대한 임상 및 시험관 내 증거Clinical Trial Published on 2021-09-012022-09-11 Journal: The American journal of pathology [Category] SARS, 유전자 메커니즘, 임상, 치료기술, [키워드] absence acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Cell clinical consequence coronavirus coronavirus 2 coronavirus disease Defense demise during pregnancy enzyme expression fetus Host immunohistochemistry In situ hybridization Infection mechanism membrane mother Newborn not express Placenta Placental infection Placentas positive control Pregnancy Pregnancy confirmed protease Protein quantification question raise receptor Replication respiratory reverse transcriptase reverse transcriptase PCR SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 virions Serine serine 2 severe acute respiratory syndrome Coronavirus supernatant syncytium term TMPRSS2 transmembrane transmembrane protease serine 2 Transmission undetectable Vero E6 vertical transmission virus [DOI] 10.1016/j.ajpath.2021.05.009 PMC 바로가기 [Article Type] Clinical Trial
Determination of the interaction between the receptor binding domain of 2019-nCoV spike protein, TMPRSS2, cathepsin B and cathepsin L, and glycosidic and aglycon forms of some flavonolsArticle Published on 2021-08-302022-10-29 Journal: Turkish Journal of Biology [Category] COVID-19, [키워드] 2019-nCoV 2019-nCoV spike protein adverse effect analyzed binding binding free energy calculated CatB cathepsin cathepsin B cathepsin L CatL cellular Compound COVID-19 Determination effective energy metabolism exhibited FIVE flavonol form glycosidic GOS high mortality in vitro in vivo inhibitory effect Interaction MM/PBSA Modification molecular molecular docking molecular dynamics Novel coronavirus protease rapidly spreading disease RBD Receptor binding domain Research SARS-CoV-2 serine 2 spike glycoprotein stability target targets therapeutic agent these compound These data TMPRSS2 Toxicity transmembrane Treatment was determined while [DOI] 10.3906/biy-2104-51 PMC 바로가기 [Article Type] Article
Age and gender differences in ACE2 and TMPRSS2 expressions in oral epithelial cells구강 상피 세포에서 ACE2 및 TMPRSS2 발현의 연령 및 성별 차이Research Published on 2021-08-192022-09-10 Journal: Journal of Translational Medicine [Category] MERS, SARS, 치료기술, 치료제, [키워드] ACE2 activate age age and gender Analysis angiotensin Angiotensin-converting enzyme bioinformatics Cell co-expressed collected coronavirus COVID-19 patients dataset detect elderly patients entry of SARS-CoV-2 entry route epithelial cell epithelial cells Evidence exhibited expression expression level expression levels expressions facilitate Factor Gender Gender differences genders Gene Expression human cell human cells immunofluorescence Infection Localization male mucosal tissues nucleic acid nucleic acids oral cavity oral mucosa oral tissue oral tissues Patient patient age patients performed Perspective positive rate potential risk protease Protein qRT-PCR receptor reported Research Result S protein Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleic acid SARS-CoV-2 susceptibility sequencing data Serine serine 2 staining supplementary material susceptibility target cells the S protein the SARS-CoV-2 tissues TMPRSS2 TMPRSS2 expression transmembrane transmembrane protease serine 2 was used western blot [DOI] 10.1186/s12967-021-03037-4 PMC 바로가기 [Article Type] Research
SARS-CoV-2 host cell entry: an in silico investigation of potential inhibitory roles of terpenoidsResearch Published on 2021-08-052022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abietane diterpenes: Molecular docking ACE2 ACE2 binding African binding binding free energy catalytic Clustering analysis COVID-19 pandemic docked docking drug drug-likeness eight Entry inhibitor first stage hotspot human Angiotensin-converting enzyme in silico in vitro in vivo inhibiting inhibitory Interaction interactions MD simulation MERS-CoV molecular molecular docking analysis pentacyclic performed plant preserved protease Protein protein targets Proteins provide residue Result S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2 host cell SARS-COV-2 infection SARS-CoV-2 spike protein screened serine 2 Spike protein stability supplementary material targeting targets terpenoids the RBD the SARS-CoV-2 therapeutic strategy TMPRSS2 trajectory transmembrane viral cell [DOI] 10.1186/s43141-021-00209-z PMC 바로가기 [Article Type] Research
New prophylaxis regimen for SARS-CoV-2 infection in health professionals with low doses of hydroxychloroquine and bromhexine: a randomised, double-blind placebo clinical trial (ELEVATE Trial)Randomized Controlled Trial Published on 2021-08-032022-10-04 Journal: BMJ Open [Category] SARS, 임상, [키워드] 1:1 ACE Administered approval approved caused cell entry cleave clinical pharmacology clinical trial clinical trials Commission COVID-19 defined double-blind early stages effective Efficacy Endpoint Ethics ethics committee expected group HCQ Health health worker healthy host cell Hydroxychloroquine Infection Infectious diseases Intervention Local low dose Luis mechanism membrane Mortality New participant Patient peer-reviewed Placebo Preventive medicine professional progression prophylactic treatment Prophylaxis protease protection protocol randomised receptor reduction in regimen risk Sample size SARS-CoV-2 SARS-COV-2 infection serine 2 shown spike glycoprotein submitted the placebo group transmembrane two group virus [DOI] 10.1136/bmjopen-2020-045190 PMC 바로가기 [Article Type] Randomized Controlled Trial