Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: interim results from a double-blind, randomised, multicentre, phase 2 trial, and 3-month follow-up of a double-blind, randomised phase 1 trial비활성화된 SARS-CoV-2 백신, BBV152의 안전성 및 면역원성: 이중 맹검, 무작위, 다기관, 2상 시험 및 이중 맹검, 무작위 1상 시험의 3개월 추적 조사의 중간 결과Clinical Trial Published on 2021-07-012022-09-12 Journal: The Lancet. Infectious Diseases [Category] Fulltext, SARS, 임상, 진단, [키워드] 1:1 95% CI Abstract addition Administered Antigen assigned baseline Bharat block blood draw cell-mediated immune response clinical trial collected defined dose double-blind Efficacy elevated elicited enrolled evaluate first dose Follow-up geometric mean GMT healthy high neutralising antibody Hindi hospital humoral inactivated India intramuscular dose investigators Local material microneutralisation test MNT multicentre neutralisation test neutralising antibody titre nine outcomes participant phase 1 trial Phase 2 study phase 2 trial Phase 3 positive Primary outcome PRNT proportion randomisation randomised Randomly reactogenicity receive Registered remained reported response Safety SARS-CoV-2 SARS-CoV-2 nucleic acid SARS-CoV-2 vaccine screened second dose second vaccination secondary outcome selected Serious Adverse Event seroconversion rate serology test significant difference significantly higher Sponsor T-cell Response Th1 phenotype the vaccine titre Toll-like receptor translation treatment group Trial Vaccine was done were assessed were excluded wild-type [DOI] 10.1016/S1473-3099(21)00070-0 PMC 바로가기 [Article Type] Clinical Trial
Expression of SARS-CoV-2 surface glycoprotein fragment 319-640 in E. coli, and its refolding and purification대장균에서 SARS-CoV-2 표면 당단백질 단편 319-640의 발현 및 이의 리폴딩 및 정제Article Published on 2021-07-012022-09-11 Journal: Protein expression and purification [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] antibody Antibody test Antigen antigenic Bacterial expression binding cells cellular receptor COVID-19 COVID-19 immunity detect determine domain E. coli Efficacy epidemiological expressed expression fragment human cells include Inclusion predict presence of antibody public health purification RBD Receptor-binding domain resulting SARS-CoV-2 sensitive serology test serology tests solubilization spike Surface glycoprotein Vaccine vaccine-induced immune response viral entry [DOI] 10.1016/j.pep.2021.105861 PMC 바로가기 [Article Type] Article
Thoracic Surgery in the COVID-19 Pandemic: A Novel Approach to Reach Guideline ConsensusArticle Published on 2021-06-242022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] absence Admission approach calculated Cancer Chest condition Consensus COVID-19 COVID-19 infection COVID-19 pandemic CT scan diagnostics Follow-up Guidance guideline guidelines Healthcare systems Hospitalization International lack management mandatory National novel organization pandemic Patient patients Precaution provide question recommendation recommendations respiratory symptom SARS-CoV-2 screened serology test suggested surgeon surgery symptomatic Thoracic Thoracic Surgery Topic [DOI] 10.3390/jcm10132769 PMC 바로가기 [Article Type] Article
Rapid Point-Of-Care Serology and Clinical History Assessment Increase Protection Provided by RT-PCR Screening: A Pilot Study Involving Three Nursing Homes in Brescia, a Hotspot of LombardyPublic Health Published on 2021-06-242022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] antibody assessment Asymptomatic Asymptomatic disease asymptomatic transmission Brescia Care clinical clinically close contact COVID-19 COVID-19 symptoms demonstrated diagnostic test effort Fisher had more history home include increase Infection Involving Italy less lombardy Measures Nursing nursing home Older on-site testing outbreak positive positive RT-PCR positive serology professional protection Protective questionnaire Rapid rapid serological assays Registered RT-PCR RT-PCR screening SARS–CoV−2 sensitivity serological serology serology test specificity Symptom tested the disease Transmission viral spread was performed [DOI] 10.3389/fpubh.2021.649524 PMC 바로가기 [Article Type] Public Health
A prospective, randomized, single-blinded, crossover trial to investigate the effect of a wearable device in addition to a daily symptom diary for the remote early detection of SARS-CoV-2 infections (COVID-RED): a structured summary of a study protocol for a randomized controlled trialSARS-COV-2 감염 (COVID-RED)의 원격 조기 발견을위한 일일 증상 일기 외에 웨어러블 장치의 효과를 조사하기위한 전향 적, 무작위, 단일 맹장, 크로스 오버 시험 : 연구의 구조적 요약.무작위 제어 시험을위한 프로토콜Letter Published on 2021-06-222022-09-01 Journal: Trials [Category] MERS, SARS, 임상, 진단, 치료기술, 치료제, [키워드] 1:1 24 hours addition adhere Algorithm Algorithms all subject all subjects analysed antibody Antibody testing antibody tests Antigen antigen tests Appointment approach asked assigned Asymptomatic asymptomatic individual asymptomatic infection average baseline blinded Blinding Bracelet can not capillary blood Chain Reaction changes in Characteristics cholinergic urticaria Cohort collected Complete conditions conducted consent form contribute control condition COVID-19 COVID-19 infection COVID-19 vaccination current Daily demographics described detect determine develop deviation diary dissemination Early detection element eligibility criteria eligible End enrolled enrolment evaluate exclusion criteria feedback Follow-up followed by gold gold standard Health health resource heart rate incidence rates Inclusion inclusion criteria individual individuals infected individual infected individuals infected with SARS-CoV-2 Infection information Informed consent informed consent form initial involved Laboratory laboratory-confirmed SARS-CoV-2 infection learning machine learning management media medical history Mobile application Month must nasal swab National natural infection Negative predictive value Netherland Netherlands notification NPV number objective occur outcome pacemaker parameter participant Participants PCR PCR test PCR tests Period phase physiological physiological parameters polymerase chain polymerase chain reaction populations portal positive Positive predictive value possession PPV pre-symptomatic Predictive value primary analysis profession proportion Prospective protocol provided Pulse rate questionnaire randomisation randomised randomised controlled trial randomization sequence Randomized Randomized controlled trial Randomly receive recommendation recruited recruitment reduce Registered reported resident resource responsible resulting risk Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 test SARS-CoV-2 virus secondary outcome sensitivity sequence sequences serology serology test serology tests significantly skin temperature Smartphone social media specificity staff status stratified stratified block randomization study participation Study protocol subject suffering supplementary material Symptom Symptom diary Symptoms target temperature test result tested the SARS-CoV-2 thought Transmission transmissions Trial Trial registration undergo urticaria used to evaluate user vaccinated against COVID-19 vaccination Vaccine Variability wearable device website Well-being [DOI] 10.1186/s13063-021-05241-5 PMC 바로가기 [Article Type] Letter
SARS-CoV-2 Infection Detection by PCR and Serologic Testing in Clinical Practice임상 실습에서 PCR 및 혈청학적 검사에 의한 SARS-CoV-2 감염 감지Article Published on 2021-06-182022-09-11 Journal: Journal of Clinical Microbiology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus antibodies Asymptomatic best clinical Clinical course complementary coronavirus Course COVID-19 cycle threshold detectable detection determine diagnosed diagnostics disease generate had no humoral immune response less limitation log Los Angele Los Angeles negative PCR tests Patient PCR PCR positive PCR test PCR tests PCR-positive patient positive PCR positive PCR test positive serology Positive test positively correlated Practice pregnant Quantitative respiratory Retrospective study SARS-CoV-2 serologic serologic test serologic tests serology serology test serology tests severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 study period symptom onset Testing the patient University of California virus-specific antibodies was performed while [DOI] 10.1128/JCM.00431-21 PMC 바로가기 [Article Type] Article
Staff SARS-CoV-2 Seroprevalence and Mental Health as Key Factors in University Response to COVID-19 PandemicPublic Health Published on 2021-06-162022-10-31 Journal: Frontiers in Public Health [Category] COVID-19, MERS, SARS, [키워드] academic environment adaptation to COVID-19 age alcohol Anxiety anxiety symptom anxiety symptoms blood collection blood draw chronic disease collected Community Contact coronavirus coronavirus disease COVID-19 COVID-19 pandemic COVID-19 symptom decrease Depression employment Estimated European Factor Gender help highest impacts implementation medication mental health non-communicable diseases Older age pandemic participant performed physical Portugal positive serology presence of comorbidity Prevalence provided psychological support public health questionnaire Rate recruited reported reported symptom respond response risk SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG antibody SARS-CoV-2 seroprevalence School serology test serology testing Seroprevalence significantly higher Spread staff subject Symptom Symptoms tested transitioned university with COVID-19 women [DOI] 10.3389/fpubh.2021.689919 PMC 바로가기 [Article Type] Public Health
Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detectionArticle Published on 2021-05-182022-10-04 Journal: Nature biotechnology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome antibody antibody tests assays Chemiluminescent microparticle immunoassay coronavirus coronavirus disease COVID-19 current detect Engineering enzyme-linked immunosorbent assays generate Host Humoral response IMPROVE lateral flow plasma point-of-care Quantitative reduce Saliva SARS-CoV-2 SARS-CoV-2 antibody sensitivity serology test serum vaccination viral infection Whole blood [DOI] 10.1038/s41587-021-00878-8 PMC 바로가기 [Article Type] Article
Antibody (Serology) Tests for COVID-19: a Case StudyCOVID-19에 대한 항체(혈청) 검사: 사례 연구Opinion/Hypothesis Published on 2021-05-122022-09-12 Journal: mSphere [Category] SARS, 진단, [키워드] antibody Antibody test Antibody testing antibody tests approach asymptomatic infection asymptomatic infections case study COVID-19 COVID-19 pandemic detect develop diagnostic test diagnostic tests diagnostics employment FDA Guidance Health identify Immunity Immunity passports infections initial Interpretation limitation market Policy positive Regulatory SARS-CoV-2 SARS-COV-2 infection serology serology test serology tests social distancing Test [DOI] 10.1128/mSphere.00201-21 PMC 바로가기 [Article Type] Opinion/Hypothesis
IgM and IgG Immunoreactivity of SARS-CoV-2 Recombinant M ProteinSARS-CoV-2 재조합 M 단백질의 IgM 및 IgG 면역반응성Article Published on 2021-05-072022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, 치료기술, 치료법, [키워드] Antigen antigenic antigenicity C-terminal convalescent COVID-19 COVID-19 sera Critical diagnostic ELISA function host cells IgG IgG reactivity IgM IgM and IgG IgM reactivity immune response immunodominance immunoreactivity investigated involved M protein membrane N-terminal nucleocapsid pattern positive produced Protein Proteins provoke purified reactivity recombinant SARS-CoV-2 SARS-CoV-2 membrane protein SARS-CoV-2 virus sera serology test serum sample serum samples shown specific antibodies specific antibody the SARS-CoV-2 the SARS-CoV-2 virus Vaccine design virion virus infection western blot [DOI] 10.3390/ijms22094951 PMC 바로가기 [Article Type] Article