eARDS: A multi-center validation of an interpretable machine learning algorithm of early onset Acute Respiratory Distress Syndrome (ARDS) among critically ill adults with COVID-19Clinical Trial Published on 2021-09-242022-10-04 Journal: PLoS ONE [Category] MERS, SARS, 임상, [키워드] 95% CI age Algorithm Analysis ARDS Atlanta AUROC Berlin Berlin criteria Care center Cerner clinical clinical criteria Cohort collected comparable conducted Control COVID-19 COVID-19 patients COVID19 patient Critically ill database demonstrated EMR exhibited Fact feature female generate groups health system health systems ICU identify independent indicate male maximum respiratory rate Mild moderate Older age oxygen saturation participant Patient performed predicted Predictive model provided respiratory Respiratory failure risk robust SBP Science sensitivity severe ARDS significantly specificity Standard deviation Systolic blood pressure university validation were used with COVID-19 [DOI] 10.1371/journal.pone.0257056 PMC 바로가기 [Article Type] Clinical Trial
Safety and preliminary efficacy of sequential multiple ascending doses of solnatide to treat pulmonary permeability edema in patients with moderate-to-severe ARDS—a randomized, placebo-controlled, double-blind trial중등도에서 중증 ARDS 환자의 폐 투과성 부종을 치료하기 위해 순차적으로 다중 상승하는 solnatide의 안전성 및 예비 효능 - 무작위, 위약 대조, 이중 맹검 시험Randomized Controlled Trial Published on 2021-09-202022-09-10 Journal: Trials [Category] SARS, 비임상, 임상, [키워드] acquisition acute respiratory distress syndrome administer alveolar animal model animal models ARDS ARDS patients breath clinical Clinical diagnosis clinical trial collected comatose complex Course Critical care data safety monitoring board decarboxylation diffusion distress dose double-blind double-blind trial edema Efficacy eligible patient Eligible patients Endpoint etiologies EU Clinical Trials EudraCT Extravascular lung water follow-up period for inclusion healthy Human Inclusion Informed consent Inhaled Intervention leads mechanical ventilation moderate moderate to severe monitoring board multiple ascending dose Oxygenation parallel group Particular pathway Patient patient safety peptide phase Phase I clinical trial Placebo placebo-controlled protocol Pulmonary edema pulmonary permeability Randomized receiving reduce Registered respiratory distress Respiratory distress syndrome Safe Safety sedated severe ARDS shown sick Solnatide syndrome treat Trial Trial registration [DOI] 10.1186/s13063-021-05588-9 PMC 바로가기 [Article Type] Randomized Controlled Trial
Killer immunoglobulin-like receptor 2DS5 is associated with recovery from coronavirus disease 2019Research Articles Published on 2021-09-032022-10-30 Journal: Intensive Care Medicine Experimental [Category] COVID-19, [키워드] activated age analyzed ARDS association Cell Cohort coronavirus disease COVID-19 cytotoxicity Defense died ECMO expression extracorporeal membrane oxygenation Factor Genotype ICU independent innate immune intensive care intensive care unit invasive mechanical investigated Killer immunoglobulin-like receptor KIR KIR2DS5 median MHC-I moderate natural NK cell NK cells outcome Patient patients with COVID-19 patients with moderate promote receptor required Result risk factor SARS-CoV-2 severe ARDS severe coronavirus disease severe COVID-19 significantly significantly higher supplementary material target cells Time to recovery transfer treated validation cohort viral infection [DOI] 10.1186/s40635-021-00409-4 PMC 바로가기 [Article Type] Research Articles
COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of CanakinumabCOVID19 관련 심근 세포 기능 장애, 부정맥 및 카나 키누맙의 효과Research Article Published on 2021-08-192022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 신약개발, 진단, [키워드] addition aims amplitude Anti-inflammatory therapy approach ARDS arrhythmia Arrhythmias baseline canakinumab cardiac function cardiac injury Cell cellular Co-incubation coronavirus coronavirus disease COVID19 COVID19 patient COVID19 patients cytokine cytokine release cytosolic decrease dysfunction Effect electrical evaluated event exposure to had no ICU IL-1β impaired cardiac function In-vitro Incubation Inflammatory response intensive care intensive care unit investigated Isolated LVEF membrane Microscopy mitigate Mortality no effect nuclear occur Patient patients pharmacological Precision RAT Result SARS-CoV-2 sensitivity serum severe ARDS Signaling significantly stem cell therapeutic potential veno-venous extracorporeal membrane oxygenation ventricular [DOI] 10.1371/journal.pone.0255976 PMC 바로가기 [Article Type] Research Article
Bacterial infections in patients hospitalized with COVID-19Im - Original Published on 2021-08-182022-10-30 Journal: Internal and Emergency Medicine [Category] COVID-19, MERS, SARS, [키워드] ARDS Bacteremia Bacterial Bacterial infection Bacterial infections complicate contribute Course COVID-19 patients COVID-19 pneumonia COVID-19 severity events examined First wave higher risk hospital hospitalized patient ICU admission Immunosuppression IMPROVE incidence increased mortality indicated Infection Kidney disease Mortality mortality rate multivariate analyses neurological Neurological disease occurred Older age pandemic Patient patients hospitalized Pneumonia predictor progressed severe ARDS severity significantly higher steroid Steroids survival survival rates tissue Tocilizumab urinary tract infection use of steroid with COVID-19 [DOI] 10.1007/s11739-021-02824-7 PMC 바로가기 [Article Type] Im - Original
Improving lung compliance by external compression of the chest wall흉벽의 외부 압박으로 폐 순응도 향상Review Published on 2021-07-282022-09-12 Journal: Critical Care [Category] 진단, [키워드] abdomen Abdominal pressure approach ARDS assumption benefit caused Chest Chest wall COVID-19 External pressure form implication Improving Intervention Local lung Lung compliance Lung protection mechanical ventilation observation Patient Prone position prone positioning recent Research Respiratory mechanics response severe ARDS Stage Supine position therapeutic transpulmonary pressure Variation [DOI] 10.1186/s13054-021-03700-8 PMC 바로가기 [Article Type] Review
Importance of Lung Ultrasound Follow-Up in Patients Who Had Recovered from Coronavirus Disease 2019: Results from a Prospective StudyArticle Published on 2021-07-202022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] affected Care Complete conducted consolidation coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 enrolled Evidence Follow-up hospital discharge Hospitalization Importance initial lesion lung Lung injury lung score lung ultrasound (LUS) Mild moderate Patient patients with SARS-CoV-2 performed Pneumonia posteroinferior Prognosis progression Prospective recovered repeated residual Result severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe ARDS Support the patient Ultrasound with COVID-19 [DOI] 10.3390/jcm10143196 PMC 바로가기 [Article Type] Article
Use of Almitrine and Inhaled Nitric Oxide in ARDS Due to COVID-19Medicine Published on 2021-07-012022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome adverse event aggravate Almitrine ARDS baseline Combination coronavirus coronavirus disease COVID-19 criteria defined Endothelial dysfunction hypertension Hypoxemia hypoxic ICU inclusion criteria Inflammation infused Inhaled intensive care manifested mechanical ventilation moderate nitric oxide Open-label Oxide oxygen Oxygenation PaO Paris Patient patients PPM Protective SARS-CoV-2 severe ARDS severe hypoxemia single-center study period syndrome therapy vasoactive drug vasoconstriction Ventilation [DOI] 10.3389/fmed.2021.655763 PMC 바로가기 [Article Type] Medicine
Neurologic manifestations in 1760 COVID-19 patients admitted to Papa Giovanni XXIII Hospital, Bergamo, ItalyObservational Study Published on 2021-07-012022-10-05 Journal: Journal of Neurology [Category] 임상, [키워드] 95% CI accumulating Altered Altered mental status Analysis anti-SARS-CoV-2 attacks Bergamo categories cerebrovascular Cerebrovascular disease cerebrovascular diseases clinician COVID-19 COVID-19 patient COVID-19 patients COVID-19 symptom CSF disorders Encephalitis had more Infectious diseases information Italy large cohort manifestation manifested Mental nervous nervous system nervous system disease neurologic neurological Neurological complication offer Patient peripheral peripheral neuropathies presenting RNA RT-PCR detection SARS-CoV-2 SARS-COV-2 infection severe ARDS Symptom Therapeutic strategies venous [DOI] 10.1007/s00415-020-10251-5 PMC 바로가기 [Article Type] Observational Study
Development and Validation of a Multivariable Predictive Model for Mortality of COVID-19 Patients Demanding High Oxygen Flow at Admission to ICU: AIDA ScoreClinical Trial Published on 2021-06-302022-10-04 Journal: Oxidative Medicine and Cellular Longevity [Category] MERS, SARS, 임상, [키워드] 95% CI addition Admission admitted to ICU age AIDA Analysis coefficient Cohort Comorbidity Coronary artery disease COVID-19 COVID-19 disease COVID-19 patient Critical care D dimer development diabete external validation Final Flow Health high risk hypertension ICU IL-6 management material mechanical ventilation men Model moderate Mortality mortality risk Most patient multivariable multivariate model Negative predictive value outcome Patient patients Positive predictive value Predictive resources Result risk Risk category risk factor score sensitivity serum albumin severe ARDS significant variable specificity Stratification study population treated utility validation validation cohort validation cohorts were used women [DOI] 10.1155/2021/6654388 PMC 바로가기 [Article Type] Clinical Trial