Proven COVID-19-associated pulmonary aspergillosis in patients with severe respiratory failure중증 호흡부전 환자에서 입증된 COVID-19 관련 폐 아스페르길루스증Article Published on 2021-10-012022-09-11 Journal: Mycoses [Category] MERS, SARS, 진단, 치료기술, [키워드] Aspergillus Autopsies CAPA clinical Clinical data collected Comorbidities Consensus COVID-19 described diagnosed diagnoses diagnostic epidemiological data Epidemiology females First wave Frequency histology incidence intensive care intensive care unit International laboratory data laboratory-confirmed Lung disease Lung diseases male median age medical mycology Mortality pandemic Patient performed pulmonary aspergillosis radiological feature radiological features reported SARS-CoV-2 second wave Seven severe COVID-19 severe respiratory failure supported to define university Validity [DOI] 10.1111/myc.13342 PMC 바로가기 [Article Type] Article
The role of angiopoietin-2 and surfactant protein-D levels in SARS-CoV-2-related lung injury: A prospective, observational, cohort studySARS-CoV-2 관련 폐 손상에서 지오포이에틴-2 및 계면활성제 단백질-D 수치의 역할: 전향적, 관찰적, 코호트 연구Observational Study Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] Fulltext, MERS, 바이오마커, 임상, [키워드] 95% CI 95% confidence interval Admission Analysis angiopoetin-2 Asymptomatic AUC characteristic Clinical data clinical manifestation Clinical severity cohort study collected community-acquired pneumonia Concentration coronavirus coronavirus disease coronavirus disease-2019 correlation COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients diagnosed diagnosed with COVID-19 early stage enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Factor groups healthy control Hospital stay initiation of treatment lung Lung injury Patient patient group patients with COVID-19 plasma samples Pneumonia Predictive predictor receiver operating characteristic respiratory Respiratory disease Respiratory failure serum serum surfactant-D. severe respiratory failure Severity of disease significantly higher the disease These data were measured [DOI] 10.1002/jmv.27184 PMC 바로가기 [Article Type] Observational Study
The MiR-320 Family Is Strongly Downregulated in Patients with COVID-19 Induced Severe Respiratory FailureArticle Published on 2021-09-262022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, SARS, [키워드] activated acute respiratory syndrome Analysis C-reactive protein characterized Coagulation Cohort coronavirus correlated Course Critically ill CRP D-dimer D-dimer levels defined demonstrated downregulation dysregulation expression extreme failure family Genome growth factor high mortality IL-6 incidence induced Infection Inflammation intubation junctions KEGG Kyoto Level Lung disease microRNA miRNA miRNA expression moderate NGS Pathway analysis Patient patients with moderate positive pressure ventilation Potential biomarker progression of disease Regulation reported respiratory Respiratory failure SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patients Sequencing Severe patient severe respiratory failure severity signaling pathway significantly significantly higher supplemental oxygen the disease Thromboembolic event thromboembolic processe with COVID-19 [DOI] 10.3390/ijms221910351 PMC 바로가기 [Article Type] Article
The growth factor/cytokine midkine may participate in cytokine storm and contribute to the pathogenesis of severe acute respiratory syndrome coronavirus 2-infected patientsReviews Published on 2021-09-252022-10-31 Journal: The Egyptian Journal of Bronchology [Category] COVID-19, [키워드] acute respiratory syndrome Admission Biomarker caused changes in contribute coronavirus coronavirus disease country COVID-19 COVID-19 patient creating critically ill patients cytokine cytokine level Cytokine storm diagnosed with COVID-19 dramatic increase Effects Endothelial cell Evidence expressed fibrosis growth health system hypoxic conditions increase in Inflammation inflammatory cell Inflammatory diseases information intensive care involved lung Midkine mild illness outbreak overexpressed overexpression pandemic Pathogenesis Patient physiological positive question released reveal SARS-CoV-2 severe respiratory failure tissue repair Treatment protocol Wuhan, China [DOI] 10.1186/s43168-021-00087-6 PMC 바로가기 [Article Type] Reviews
Delayed Initiation of ECMO Is Associated With Poor Outcomes in Patients With Severe COVID-19: A Multicenter Retrospective Cohort StudyMedicine Published on 2021-09-162022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] acute respiratory distress syndrome Analysis Blood chest X-ray Chinese clinical Clinical course collected complications Coronavirus disease 2019 COVID-19 criteria Delayed demographics ECMO enrolled Extracorporeal extracorporeal membrane oxygenation Gas exchange heart failure hospital information initiated Initiation interquartile range IQR Laboratory lung membrane Mortality mortality rate multicenter cohort study Novel coronavirus outcome Oxygenation Patient patients with COVID-19 Pneumonia Poor Primary outcome Region registry Respiratory failure retrospective risk factor severe coronavirus disease Severe patient severe respiratory failure shown the patient the timing therapy treated Treatment treatment groups Trial vital signs with COVID-19 [DOI] 10.3389/fmed.2021.716086 PMC 바로가기 [Article Type] Medicine
Combined Percutaneous Tracheostomy and Endoscopic Gastrostomy Tubes in COVID-19: A Prospective Series of Patient OutcomesOriginal Research Published on 2021-08-232022-10-29 Journal: Journal of Intensive Care Medicine [Category] COVID-19, MERS, SARS, [키워드] addition approach clinically collected Combined COVID-19 COVID-19 patient COVID-19 patients Critically ill decannulated Descriptive statistics discharge discharged Effectiveness Efficacy endpoints evaluate gastrostomy healthcare personnel Healthcare provider hospital ICU intensive care mechanical ventilation median Mortality Patient patients patients with COVID-19 Percutaneous Prospective prospective cohort study question required Respiratory failure risk Sery severe respiratory failure survival the median the timing tracheostomy tracheostomy tube transfer tube undergo virus transmission [DOI] 10.1177/08850666211038875 PMC 바로가기 [Article Type] Original Research
Convalescent COVID-19 Patients Without Comorbidities Display Similar Immunophenotypes Over Time Despite Divergent Disease Severities동반 질환이 없는 회복기 COVID-19 환자는 다양한 질병 중증도에도 불구하고 시간이 지남에 따라 유사한 면역 표현형을 나타냅니다Immunology Published on 2021-08-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술, [키워드] abrogation affected analyzed asymptomatic infection caused Comorbidities convalescence convalescent convalescent COVID-19 patient convalescent COVID-19 patients correlated COVID-19 COVID-19 cohort detectable disease course disease severity disease severity assessment display flow cytometric Host immune response immune immune signature immunological immunomonitoring immunophenotype Infection majority mononuclear cell mononuclear cells over Patient PBMCs Peripheral blood Peripheral blood mononuclear cells phenotype Respiratory failure risk factor SARS-CoV-2 SARS-COV-2 infection serum severe respiratory failure stratified T cells the disease time transcriptomics unique [DOI] 10.3389/fimmu.2021.601080 PMC 바로가기 [Article Type] Immunology
Temporal change in Syndecan-1 as a therapeutic target and a biomarker for the severity classification of COVID-19Research Published on 2021-08-162022-10-29 Journal: Thrombosis Journal [Category] COVID-19, [키워드] Admission Analysis analyzed Biomarker Care center city classification Clinical data Coronavirus disease 2019 Course COVID-19 COVID-19 patient Critical critical COVID-19 patient critical COVID-19 patients CRP level ELISA endothelial endothelial injury Factor FIVE glycocalyx high mortality intensive care laboratory data LDH no significant difference pathogenesis of COVID-19 Platelet required Result selected severe COVID-19 severe COVID-19 patient severe respiratory failure severity severity of COVID-19 significant difference significantly significantly higher SOFA score Syndecan-1 Temporal therapeutic target two groups university Yokohama [DOI] 10.1186/s12959-021-00308-4 PMC 바로가기 [Article Type] Research
Rationale for Polyclonal Intravenous Immunoglobulin Adjunctive Therapy in COVID-19 Patients: Report of a Structured Multidisciplinary ConsensusArticle Published on 2021-08-082022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] available data bacterial superinfection clinical phenotype Consensus COVID-19 COVID-19 patient COVID-19 patients defined dysregulated early phase Effectiveness Evidence Hyperinflammatory immune Immunocompromised patients immunotherapies Infection intravenous intravenous immunoglobulin therapy IVIG late phase literature review management manuscript mechanism ongoing trial paralysis pathobiology of COVID-19 Patient phenotype polyclonal rationale report Respiratory failure Sepsis severe COVID-19 severe respiratory failure Shock the SARS-CoV-2 therapy was used [DOI] 10.3390/jcm10163500 PMC 바로가기 [Article Type] Article
A quantitative analysis of extension and distribution of lung injury in COVID-19: a prospective study based on chest computed tomographyObservational Study Published on 2021-08-042022-10-04 Journal: Critical Care [Category] MERS, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome Analysis analyzed ARDS cause Chest computed tomography clinical Clinical features Cohort composed Computed tomography correlation COVID-19 COVID-19 patient D-dimer defined detect distribution eligible extension feature ferritin Hypothesis Inflammation Injury investigated laboratory feature lung Lung injury mechanical ventilation nonparametric test Patient plasma predominant progression Prolonged Prospective Study Quantitative analysis recruited Region regions Registered Result SARS-CoV2 selected severe respiratory failure significantly more Spearman correlation test Spread subpleural subpleural distribution supplementary material syndrome thrombosis Typical Volume was used were used [DOI] 10.1186/s13054-021-03685-4 PMC 바로가기 [Article Type] Observational Study