Key Considerations for the Development of Safe and Effective SARS‐CoV‐2 Subunit Vaccine: A Peptide‐Based Vaccine Alternative안전하고 효과적인 SARS -COV -2 서브 유닛 백신 개발을위한 주요 고려 사항 : 펩티드 기반 백신 대안Review Published on 2021-06-272022-09-01 Journal: Advanced Science [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] angiotensin‐converting enzyme 2 antibody‐dependent enhancement Antigen antigens B‐cell clinical symptom conserved COVID‐19 critical binding residues deleted development developmental disorder Economy effective effective vaccine Effective vaccines Epitopes exhibit focus genetic material global health Health immune response immune responses immunogenic immunopathological Infection mechanisms mutant Neutralizing Neutralizing antibodies nonstructural protein peptide peptide vaccine Peptide vaccines Protective protective role Protein Proteins Receptor binding domain Safe SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 similarities similarity Spike protein T‐cell type‐I interferons Vaccine vaccine antigen Vaccines Viral Viral protein Viral proteins virus [DOI] 10.1002/advs.202100985 PMC 바로가기 [Article Type] Review
Inflammatory Mechanisms in COVID-19 and Atherosclerosis: Current Pharmaceutical PerspectivesCOVID-19 및 죽상동맥경화증의 염증 기전: 현재의 약학적 관점Review Published on 2021-06-212022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-inflammatory agents anti-inflammatory treatment Arrhythmias Atherosclerosis atherosclerotic atherosclerotic heart disease cardiovascular event Cardiovascular events cardiovascular system caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 current disease endothelial injury excess mortality heart disease immunomodulator immunomodulators Inflammation inflammatory pathway inflammatory pathways involved Mortality myocardial injury myocarditis pharmaceutical reduction SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe complications similarities similarity systemic inflammatory response thrombotic thrombotic event Treatment Venous Thromboembolism [DOI] 10.3390/ijms22126607 PMC 바로가기 [Article Type] Review
Impact of Coronavirus Outbreaks on Science and Society: Insights from Temporal Bibliometry of SARS and COVID-19Article Published on 2021-05-182022-10-31 Journal: Information Sciences [Category] COVID-19, [키워드] 2003 SARS Analysis bibliometry changes in coronavirus Course COVID-19 COVID-19 crisis COVID-19 pandemic Effect Epidemic event flu foci Impact individual information insight instantaneous media MERS MOST network analysis pandemic provide Research response SARS Science similarities Temporal text and data mining viral epidemics [DOI] 10.3390/e23050626 PMC 바로가기 [Article Type] Article
Sources of SARS-CoV-2 and Other Microorganisms in Dental AerosolsResearch Reports Published on 2021-05-122022-10-29 Journal: Journal of Dental Research [Category] COVID-19, SARS, [키워드] aerosol Analysis assistant asymptomatic patient Bacterial Case report contributed COVID-19 pandemic dental dental implants dentist dissimilarity DNA sequence analysis equipment identify infection control information irrigant knowledge measure median Microbiome microbiota microorganism operator Other Pathogens Patient patients polymerase chain Quantitative resource respiratory pathogen risk Safe Saliva salivary SARS-CoV-2 SARS-CoV-2 virus Sequencing similarities Source the United State transcriptase Transmission transmission of SARS-CoV-2 Treatment ultrasonics urgency [DOI] 10.1177/00220345211015948 PMC 바로가기 [Article Type] Research Reports
Can reasoned mass testing impact covid-19 outcomes in wide community contexts? An evidence-based opinion합리적인 대량 테스트가 광범위한 커뮤니티 맥락에서 코로나19 결과에 영향을 미칠 수 있습니까? 증거 기반 의견Comment Published on 2021-05-012022-09-11 Journal: Pathogens and global health [Category] SARS, 치료기술, [키워드] adoption affecting Asymptomatic Can Case fatality rate Community COVID-19 COVID-19 epidemic disease early phase Fatality rate Hospitalization Italian regions Italy limitation lombardy mass Mortality outcome regions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 Mass testing similarities similarity symptomatic cases Testing Veneto veneto. [DOI] 10.1080/20477724.2021.1878444 PMC 바로가기 [Article Type] Comment
Comprehensive evaluation of the efficacy and safety of LPV/r drugs in the treatment of SARS and MERS to provide potential treatment options for COVID-19COVID-19에 대한 잠재적인 치료 옵션을 제공하기 위해 SARS 및 MERS 치료에서 LPV/r 약물의 효능 및 안전성에 대한 종합 평가Meta-Analysis Published on 2021-04-302022-09-10 Journal: Aging (Albany NY) [Category] MERS, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome addition adverse event adverse events age and sex analyzed Antiviral treatment applied ARDS assessment tool benefit bias risk case-control studies CBM Chest CT China CNKI Cochrane Library Cohort studies Combination comprehensive evaluation conducted control group conversion rate coronavirus disease Coronavirus disease 2019 Coronavirus infections COVID-19 COVID-19 treatment database drug effective Effectiveness Efficacy Efficacy and safety eligible evaluate exhibited Factor incidence Infrastructure literature Lopinavir Lopinavir/ritonavir lower mortality LPV/r MERS Meta-analysis Middle East Middle East respiratory syndrome molecular Newcastle-Ottawa Scale NOS nucleic acid outbreak outcome patients patients with COVID-19 patients with SARS performed potential treatment option prognostic Randomized controlled studies RCT reduced Registration respiratory respiratory distress retrieved Risk assessment Ritonavir SARS Severe acute respiratory syndrome significantly similarities similarity statistically significant Structure syndrome systematic review the Newcastle-Ottawa Scale these viruses Treatment treatment of COVID-19 Trial two group two groups virus clearance viruses was used were used [DOI] 10.18632/aging.202860 PMC 바로가기 [Article Type] Meta-Analysis
Multiscale statistical physics of the pan-viral interactome unravels the systemic nature of SARS-CoV-2 infections Research Published on 2021-04-232022-10-05 Journal: Communications Physics [Category] 신약개발, [키워드] biological pathway biological processe Characterizing molecular Cluster complementary disease Effect exhibit expected feature Herpe HIV1 Human human cells humans Infection information Interaction multiple organ new virus Novel coronavirus Perspective physical Protein Regulatory respiratory responsible SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral similarities statistical virus viruses [DOI] 10.1038/s42005-021-00582-8 [Article Type] Research
Longitudinal assessment of IFN-I activity and immune profile in critically ill COVID-19 patients with acute respiratory distress syndrome급성 호흡 곤란 증후군이 있는 중환자 COVID-19 환자의 IFN-I 활성 및 면역 프로파일에 대한 종단 평가Clinical Trial Published on 2021-04-122022-08-13 Journal: Critical Care [Category] MERS, 바이오마커, 임상, [키워드] acute respiratory distress acute respiratory distress syndrome alteration appear ARDS ARDS patient ARDS patients Bacterial sepsis cellular COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients cytokine cytokine levels Cytokines decrease described Elevation expression followed by Hospital stay ICU admission IFN response IFN-I IFN-stimulated gene IFN-stimulated genes IFNα2 immune immune parameter Immune profile immune response immune responses immuno-inflammatory Immunosuppression intensity ISG longitudinal longitudinal immune monitoring lymphocyte Lymphocyte count marker mHLA-DR non-survivor normal values Occurrence outcome pandemic plasma question respiratory distress Result SARS-CoV2 infection Secondary infection secondary infections Sepsis similarities similarity supplementary material Survivors syndrome TNF-α Type-I IFN [DOI] 10.1186/s13054-021-03558-w PMC 바로가기 [Article Type] Clinical Trial
Why are ACE2 binding coronavirus strains SARS-CoV/SARS-CoV-2 wild and NL63 mild?ACE2 결합 코로나바이러스 균주 SARS-CoV/SARS-CoV-2가 야생이고 NL63이 약한 이유는 무엇입니까?Article Published on 2021-04-012022-09-11 Journal: Proteins [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 binding angiotensin Angiotensin-converting enzyme antiviral drug antiviral drugs binding binding site Cluster conserved coronavirus coronavirus spike protein coronavirus strain coronavirus strains Coronaviruses COVID-19 COVID-19 pandemic drugs effort enzyme Epidemics etiology feature flexibility help human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrophobic hydrophobicity identify indicated Interaction involved MERS mutational analysis NL63 Point mutation Protein Research researcher residue residues responsible reveal SARS SARS-CoV SARS-CoV-2 virus severity similarities similarity Spike protein Spike proteins strain Strains surrounding hydrophobicity. the spike protein therapeutic virus Virus-host interactions [DOI] 10.1002/prot.26024 PMC 바로가기 [Article Type] Article
The cytokine storm in COVID-19: Further advances in our understanding the role of specific chemokines involvedCOVID-19의 사이토카인 폭풍: 관련된 특정 케모카인의 역할에 대한 이해의 추가 발전Review Published on 2021-04-012022-09-11 Journal: Cytokine & growth factor reviews [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accumulate chemokine Chemokine receptor chemokines Chemokines. Clinical course Clinical studies clinical study complex contribute COVID-19 COVID-19-coronavirus current CXCL10 CXCL8 CXCL8 - cytokine storm cytokine Cytokine storm Cytokines deaths disease Evidence Future immune signature in vitro in vivo Infection involved issue knowledge less maintenance pandemic Patient patients patients with COVID-19 positive predict pro-inflammatory progression provide provided reported risk stratification SARS-COV-2 infection scenario similarities similarity subject the cytokine storm the disease Topic virus [DOI] 10.1016/j.cytogfr.2020.12.005 PMC 바로가기 [Article Type] Review