Ledipasvir plus sofosbuvir in pregnant women with hepatitis C virus infection: a phase 1 pharmacokinetic studyC형 간염 바이러스 감염 임산부에 대한 레디파스비르 + 소포스부비르: 1상 약동학 연구Article Published on 2020-08-132022-09-06 Journal: The Lancet. Microbe [Category] Communicable Disease, [키워드] All participants Alter analysed AUC changes in Child child health clinically concentration–time curve Course development dosing interval during pregnancy effective enrolled Epidemic finding funding genotype 1 geometric geometric mean geometric mean ratio gestation HCV Hepatitis hepatitis C hepatitis C virus Human Human Development Infants Infection Intensive Intervention ledipasvir Magee-Womens Hospital nine Open-label opioid parameter participant participated pharmacokinetic pharmacokinetics Phase 1 phase 1 study Phase 2 Physiological changes Pittsburgh Pregnancy pregnant pregnant women primary analysis Primary outcome reduce Registered Safe screened sofosbuvir sofosbuvir) Transmission treat Trial USA virus was used women [DOI] 10.1016/S2666-5247(20)30062-8 PMC 바로가기 [Article Type] Article
Sofosbuvir as Repurposed Antiviral Drug Against COVID-19: Why Were We Convinced to Evaluate the Drug in a Registered/Approved Clinical Trial?Research article Published on 2020-08-012022-10-05 Journal: Archives of medical research [Category] SARS, 신약개발, 임상, 치료제, [키워드] addition Against antivirals approved clinical clinical trial clinically Combination conserved COVID-19 drug Drug repurposing evaluate the effect Flaviviridae global pandemic HCV help individual infected case inhibited International lung damage majority metabolite Mild polymerase regimen respiratory complication RNA RNA virus Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RdRp Scientific community sofosbuvir specific treatment stability Standard of care susceptible therapeutic Togaviridae Treatment virus while [DOI] 10.1016/j.arcmed.2020.04.018 [Article Type] Research article
Sofosbuvir as a potential alternative to treat the SARS-CoV-2 epidemicArticle Published on 2020-06-092022-10-04 Journal: Scientific Reports [Category] SARS, 변종, 치료제, [키워드] Antiviral approved conserved coronavirus Epidemic hepatitis C virus Infection infections Molecular medicine Pathogens polymerase residue SARS-CoV SARS-CoV-2 sofosbuvir the SARS-CoV-2 treat Treatment Vaccine Virology viruses [DOI] 10.1038/s41598-020-66440-9 PMC 바로가기 [Article Type] Article
Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potencyArticle Published on 2020-05-152023-07-02 Journal: The Journal of Biological Chemistry [Category] SARS, [키워드] Coronavirus (CoV) COVID-19 drug action Drug development Drug discovery Ebola virus Favipiravir Lassa virus MERS plus-stranded RNA virus Remdesivir Replication ribavirin RNA polymerase RNA-dependent RNA polymerase (RdRp) SARS SARS-CoV-2 sofosbuvir [DOI] 10.1074/jbc.RA120.013679 PMC 바로가기
Knowledge-based repositioning of the anti-HCV direct antiviral agent Sofosbuvir as SARS-CoV-2 treatmentShort Report Published on 2020-05-122022-10-30 Journal: Infectious Agents and Cancer [Category] COVID-19, [키워드] Analysis Anti-HCV Antiviral binding coronavirus COVID19 drug Efficiency likelihood limit pandemic positive-sense RNA virus progression of disease RdRP SARS-CoV-2 SARS-CoV-2 treatment sequence sofosbuvir structural homology the SARS-CoV-2 Treatment virus [DOI] 10.1186/s13027-020-00302-x PMC 바로가기 [Article Type] Short Report
Anti-HCV, nucleotide inhibitors, repurposing against COVID-19Research article Published on 2020-05-012022-10-05 Journal: Life sciences [Category] SARS, 신약개발, [키워드] Anti-HCV anti-polymerase drugs approved drug build China confirmed case COVID-19 death deaths disease docking drug Effectiveness Efficiency Human human coronavirus IDX-184 in silico inhibitors material MERS nucleotide Nucleotide inhibitors RdRP reported responsible RNA RNA polymerase Sequence analysis Significance sofosbuvir structural bioinformatics Transmission viral infection WHO World Health Organization Wuhan Wuhan coronavirus Wuhan, China [DOI] 10.1016/j.lfs.2020.117477 [Article Type] Research article
Sofosbuvir-/Daclatasvir-based therapy for chronic HCV and HCV/hepatitis B virus coinfected patients in EgyptArticle Published on 2020-02-072023-06-12 Journal: Transactions of the Royal Society of Tropical Medi [Category] B형 간염, [키워드] BMS-790052 Egypt HCV ribavirin sofosbuvir [DOI] 10.1093/trstmh/trz079
Successful treatment of HBV, HCV, & HEV, with 12-week long use of tenofovir, sofosbuvir, daclatasvir, and ribavirin: A case reportCase Reports Published on 2020-01-012023-06-10 Journal: Journal of infection and public health [Category] B형 간염, E형 간염, [키워드] Asthma diabetes HBV HCV HEV sofosbuvir [DOI] 10.1016/j.jiph.2019.06.004 [Article Type] Case Reports
Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitroArticle Published on 2019-10-012023-06-11 Journal: Antiviral Research [Category] E형 간염, [키워드] 2′-C-Methylguanosine Antiviral agents combination therapy hepatitis E virus sofosbuvir [DOI] 10.1016/j.antiviral.2019.104570
Patient-reported outcomes in patients chronic viral hepatitis without cirrhosis: The impact of hepatitis B and C viral replicationClinical Trial Published on 2019-10-012023-06-19 Journal: Liver international : official journal of the Inte [Category] B형 간염, [키워드] activity Direct-acting antivirals oral anti-viral therapy Quality of life sofosbuvir vesatolimod. [DOI] 10.1111/liv.14171 [Article Type] Clinical Trial