Clinical efficacy of iodine complex in SARS-CoV-2-infected patients with mild to moderate symptoms: study protocol for a randomized controlled trial경증에서 중등도의 증상을 보이는 SARS-CoV-2 감염 환자에서 요오드 복합체의 임상 효능: 무작위 대조 시험을 위한 연구 프로토콜Update Published on 2022-01-192022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] adaptive addition alleviate analyzed Arm benefit both groups caused Chest clinic clinical clinical trial collected Combination complex Computed tomography conducted coronavirus disease Coronavirus disease 2019 Coronavirus-2 country COVID-19 COVID-19 patient COVID-19 patients doctor Efficacy High-resolution Hospitalization HRCT implication IMPROVE in both groups Intervention Iodine lower mortality Mild mild to moderate mild to moderate symptoms moderate Mortality Novel coronavirus pandemic parallel group parameter Patient Placebo placebo-controlled Polymer questionnaire radiological improvement Randomized controlled trial randomized trial receive reduction in respiratory respiratory syndrome coronavirus RT-PCR Sample size SARS-CoV-2 SARS-CoV-2-infected patient SAS version 9.4 severe respiratory syndrome socioeconomic status standard care Study protocol symptomatic Symptoms syrup Treatment treatment of COVID-19 Trial Trial registration Viral Viral load viral load reduction with COVID-19 written consent [DOI] 10.1186/s13063-021-05848-8 PMC 바로가기 [Article Type] Update
Awake Prone Positioning, High-Flow Nasal Oxygen and Non-Invasive Ventilation as Non-Invasive Respiratory Strategies in COVID-19 Acute Respiratory Failure: A Systematic Review and Meta-AnalysisSystematic Review Published on 2022-01-132022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% CI Acute respiratory failure Alter app appear Awake prone positioning benefit certainty COVID-19 COVID-19 patient COVID-19 patients death decrease Efficacy and safety Evidence HFNC High-flow nasal cannula intubation intubation rate moderate Mortality nasal NIV non-invasive ventilation organ dysfunction oxygen patients positioning prone Randomized controlled trial RCT RCTs remains uncertain respiratory Respiratory failure review risk searched standard care Strategy substantial risk systematic review while [DOI] 10.3390/jcm11020391 PMC 바로가기 [Article Type] Systematic Review
Awake prone positioning in nonintubated spontaneous breathing ICU patients with acute hypoxemic respiratory failure (PRONELIFE)—protocol for a randomized clinical trial삽관되지 않은 자발 호흡 중환자 중 급성 저산소성 호흡 부전(PROONELIFE) 환자의 깨어 있는 엎드린 자세 - 무작위 임상 시험을 위한 프로토콜Study Protocol Published on 2022-01-102022-09-10 Journal: Trials [Category] 임상, [키워드] Acute hypoxemic respiratory failure Acute respiratory failure all-cause mortality assigned Awake prone positioning benefit Blinding Clinical management clinical trial complications Composite consecutive patients Critically ill Critically ill patient critically ill patients determine duration of use Dyspnea Effect eligible Endpoint enrolment etiology hospital Hypoxemia hypoxemic Hypoxemic respiratory failure ICU ICU patient ICU Patients include International intubation intubation rate invasive invasive ventilation investigator-initiated ISRCTN lung tissue Mortality multicenter noninvasive respiratory Other Oxygenation parameters Patient Pragmatic Prevent primary endpoint Prone position prone positioning randomized clinical trial Randomized controlled trial Randomly reduction in reference number Registered respiratory Respiratory failure secondary Secondary endpoints spontaneous breathing standard care Support Tolerance tracheal tracheal intubation Trial Ventilation [DOI] 10.1186/s13063-021-05991-2 PMC 바로가기 [Article Type] Study Protocol
A prospective clinical evaluation of a patient isolation hood during the COVID-19 pandemicResearch article Published on 2022-01-012022-10-05 Journal: Australian critical care : official journal of the Confederation of [Category] SARS, 임상, [키워드] acute respiratory syndrome adverse event adverse events assessment association attack rate carried clinical evaluation collected coronavirus coronavirus disease COVID-19 COVID-19 infection COVID-19 pandemic cross cross-contamination diagnosis of COVID-19 eight eligible HCW HCWs healthcare worker hospital ICU ICUs Infection intensive care unit Isolation measure objective outcome measure Patient patient safety patients patients with COVID-19 practicality Prevent prospective cohort study question questionnaire rates of infection recorded reduce registered nurse reported responses Result Safe standard care study period therapy thought variety [DOI] 10.1016/j.aucc.2021.05.001 [Article Type] Research article
Effects of different corticosteroid therapy on severe COVID-19 patients: a meta-analysis of randomized controlled trials중증 COVID-19 환자에 대한 다양한 코르티코스테로이드 요법의 효과: 무작위 대조 시험의 메타 분석Meta-Analysis Published on 2022-01-012022-09-11 Journal: Expert review of respiratory medicine [Category] SARS, 임상, [키워드] adverse event adverse events analyzed benefit clinical trials Corticosteroid corticosteroid therapy corticosteroid treatment corticosteroid treatments Corticosteroids COVID-19 COVID-19 patient COVID-19 patients database Dexamethasone dosage dose drug Effect Efficacy Efficacy and safety eligible evaluated expert for inclusion identify IMPROVE increased mortality low dose dexamethasone management mechanical ventilation Meta-analysis Mortality no difference opinion oxygen oxygen support patient survival Placebo randomized clinical trial Randomized controlled trial RCTs reduce reduction risk of death searched Secondary infection secondary infections severe COVID-19 severe COVID-19 patient severe COVID-19 patients significantly standard care statistical analysis subgroup of patient subgroup of patients survival Treatment treatment of COVID-19 patients Trial use of corticosteroid [DOI] 10.1080/17476348.2021.1983429 PMC 바로가기 [Article Type] Meta-Analysis
Model-based cost-effectiveness analysis of oral antivirals against SARS-CoV-2 in Korea국내 SARS-CoV-2에 대한 경구용 항바이러스제의 모델 기반 비용 효율성 분석Article Published on 2022-01-012022-09-11 Journal: Epidemiology and Health [Category] SARS, 치료제, [키워드] Admission Adult patients Adults Analysis Antiviral antiviral agent Antiviral agents calculated Care coronavirus disease Coronavirus disease 2019 Cost-effectiveness analysis country COVID-19 COVID-19 patient Efficacy Elderly patient elderly patients Emergency use group health system Hospital admission Hospitalization ICU less medical system Mild-to-moderate molnupiravir Nirmatrelvir Patient patients predicted reduce reducing Ritonavir SARS-CoV-2 Severe case severe COVID-19 Severe patient standard care symptomatic Treatment underlying disease underlying diseases [DOI] 10.4178/epih.e2022034 PMC 바로가기 [Article Type] Article
A randomized controlled study of convalescent plasma for individuals hospitalized with COVID-19 pneumoniaCOVID-19 폐렴으로 입원한 개인을 위한 회복기 혈장의 무작위 대조 연구Randomized Controlled Trial Published on 2021-12-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 임상, 진단, [키워드] 28-day mortality Adaptive immunity Administered adults hospitalized anti-SARS-CoV-2 anti-SARS-CoV-2 antibody benefit CCP clinical clinical severity score clinical trials Comorbidities convalescent plasma COVID-19 disease Efficacy enrolled Evidence Hospitalization Hospitalized hospitalized patient Immunosuppression include individual interquartile range majority mechanical ventilation median outcome measure Oxygenation participant performed Pneumonia populations primary efficacy endpoint Randomized randomized controlled study randomized trial Result risk factor Safe SARS-CoV-2 RNA secondary outcome seronegative seronegative participant severe COVID-19 shown standard care Symptom those with comorbidity treated Treatment Trial WHO with COVID-19 [DOI] 10.1172/JCI155114 PMC 바로가기 [Article Type] Randomized Controlled Trial
High-Dose Dexamethasone Versus Tocilizumab in Moderate to Severe COVID-19 Pneumonia: A Randomized Controlled TrialEmergency Medicine Published on 2021-12-112022-10-31 Journal: Cureus [Category] COVID-19, [키워드] 28-day mortality 48 hour 95% confidence interval acute respiratory distress acute respiratory distress syndrome (ARDS) adverse events all-cause mortality appear ARDS assigned Cohen’s d Controlled COVID-19 Cytokine storms Dexamethasone Efficacy and safety Fungal infection High-dose high-dose dexamethasone incidence indicated initial interim analysis median mitigate moderate Mortality NNT patients Primary outcome pulse dose steroids Randomized controlled trial Randomly receive recent Result risk Secondary infection secondary outcome severe coronavirus disease severe COVID-19 significantly significantly lower standard care study population syndrome TCZ the cytokine storm Therapeutic benefit Tocilizumab Trial ventilator-free day VFD worsening [DOI] 10.7759/cureus.20353 PMC 바로가기 [Article Type] Emergency Medicine
Convalescent plasma for treatment of COVID-19: study protocol for an open randomised controlled trial in SwedenCovid-19의 치료를위한 회복기 혈장 : 스웨덴의 공개 무작위 대조 시험을위한 연구 프로토콜Infectious Diseases Published on 2021-12-072022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 임상, [키워드] airway Analysis antibody antibody levels article authority benefit block Block randomisation Blood blood bank & transfusion medicine blood sample Blood samples clinical study control arm convalescent plasma COVID-19 dissemination dose doses Endpoint enrolled Ethical approval Ethics group hospital include infection control intensive & critical care literature review Mortality neutralising antibody titre open participant Patient patients with COVID-19 plasma positive primary endpoint public health randomisation randomised controlled trial reduced registration number Result review SARS-CoV-2 secondary Secondary endpoints standard care study inclusion Study protocol Swedish Swedish Ethical Review Authority the patient therapy titre Treatment treatment of COVID-19 Trial Trial Registration Number Viraemia Virology virus [DOI] 10.1136/bmjopen-2020-048337 PMC 바로가기 [Article Type] Infectious Diseases
Convalescent Plasma Reduces Endogenous Antibody Response in COVID-19: A Retrospective Cross-Sectional StudyBrief Report Published on 2021-12-072022-10-28 Journal: Turkish Journal of Hematology [Category] COVID-19, SARS, [키워드] addition age antibody Antibody titer benefit Comorbidity control group convalescent plasma COVID-19 COVID-19 antibody COVID-19 antibody test COVID-19 patient CP group disease endogenous enrolled Gender hospitalized COVID-19 patient Immunity investigated material outcome Patient patients recipient recorded reduced response significantly standard care Standard-of-care therapy Total Treatment [DOI] 10.4274/tjh.galenos.2021.2021.0277 PMC 바로가기 [Article Type] Brief Report