Combining Deep Phenotyping of Serum Proteomics and Clinical Data via Machine Learning for COVID-19 Biomarker DiscoveryCOVID-19 바이오마커 발견을 위한 기계 학습을 통한 혈청 단백질체학 및 임상 데이터의 심층 표현형 결합Article Published on 2022-08-152022-09-11 Journal: International Journal of Molecular Sciences [Category] 바이오마커, 유전자 메커니즘, [키워드] analyzed Biomarker Biomarkers cardiometabolic CD200R1 Central nervous system clinical Clinical practice contributed COVID-19 COVID-19 disease COVID-19 disease severity COVID-19 patient dataset deep disease disease severity Diseases downregulated enrolled Factors IL6 IMPROVE Inflammation KIT LTBP2 lymphocyte lymphocyte counts machine learning MATN3 MCP1 MOST MRAP natural history neurologic neurologic disease neutrophil nine outcome pathology persistence Phenotyping Protective Protein proximity extension assay sera serological data serum biomarker serum biomarkers severe cases small sample size statistical TRANCE unique variable [DOI] 10.3390/ijms23169161 PMC 바로가기 [Article Type] Article
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results Research Published on 2022-08-152022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, 치료법, [키워드] Adenovirus adverse event analyses Analysis benefit Biomarker CD8 T cell circulating Colorectal cancer Combination CPI diarrhea disease DNA dose Endpoint fatigue feasibility feasible Heterologous immune inhibitor injection site pain Ipilimumab limit long-lasting mRNA Musculoskeletal nivolumab Patient phase 1 trial primary endpoint Pyrexia randomized studies reactivity regimen responses Safe Safety secondary solid tumor statistical survival therapy Tolerability toxicities transaminase translational Tumor vaccination Vaccine viral particle were assessed [DOI] 10.1038/s41591-022-01937-6 [Article Type] Research
Modeling Global COVID-19 Dissemination Data After the Emergence of Omicron Variant Using Multipronged Approaches다각적 접근 방식을 사용하여 오미크론 변이체 출현 후 글로벌 COVID-19 보급 데이터 모델링Article Published on 2022-08-102022-09-11 Journal: Current microbiology [Category] SARS, 변종, [키워드] among others approach basic Behavior collected compartmental model country COVID-19 COVID-19 dissemination COVID-19 pandemic data set data sets determine develop disease spread distribution drop emergence Factor fitting followed by Formula human behavior incidence increase in Infection infection rate infection rates information Interpretation management measure modeling number omicron pandemic reproduction Research Sery Spread statistical text the disease time Transmission vaccination vaccination efficacy variants of SARS-CoV-2 vulnerable population yielding [DOI] 10.1007/s00284-022-02985-4 PMC 바로가기 [Article Type] Article
Tempo-Spatial Modelling of the Spread of COVID-19 in Urban Spaces도시 공간에서 COVID-19의 확산에 대한 시공간 모델링Article Published on 2022-08-082022-09-11 Journal: International Journal of Environmental Research an [Category] 변종, [키워드] Analysis approach changed city consequence contagious contagious disease COVID-19 COVID-19 pandemic disease disparity distribution evaluate Evolution exceptional explain greater increasingly Infection intensity Malaga pandemic Perspective selected shown social areas social structure socio-spatial structure Space Spain Spread statistical statistical analysis theory urban urban spaces. variable variant [DOI] 10.3390/ijerph19159764 PMC 바로가기 [Article Type] Article
Statistical framework to support the epidemiological interpretation of SARS-CoV-2 concentration in municipal wastewater도시 폐수 내 SARS-CoV-2 농도의 역학 해석을 지원하는 통계적 프레임워크Article Published on 2022-08-052022-09-11 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Bayesian Canada Concentration coronavirus COVID-19 pandemic Data analysis data set detect detectable epidemiological functional infected individual infected individuals Interpretation observation observations Previous studies Ribonucleic acid RNA SARS-CoV-2 severe acute respiratory syndrome Coronavirus severity statistical statistical framework Support Surveillance surveillance data trajectory Viral concentration viral concentrations virus wastewater [DOI] 10.1038/s41598-022-17543-y PMC 바로가기 [Article Type] Article
357 Skin cancer treatment delays during the COVID-19 pandemicConference abstract Published on 2022-08-012022-10-30 Journal: The Journal of investigative dermatology [Category] Coronavirus, 치료법, [키워드] adverse outcomes age analyzed average Bladder cancer Brain Breast cancer calculated Cancer cancer treatment cancer type Care Colon cancer Colorectal cancer coronavirus COVID-19 pandemic Frequency had more Health IBM information interview investigated leukemia likelihood lung cancer Melanoma Metastasis Mortality multivariate observation Odds ratio P-value Pancreatic cancer pandemic Patient presenting provide respondent significantly more skin cancer SPSS statistical statistically significant study cohort survey Treatment [DOI] 10.1016/j.jid.2022.05.366 [Article Type] Conference abstract
Network methods and design of randomized trials: Application to investigation of COVID-19 vaccination boosters네트워크 방법 및 무작위 시험 설계: 코로나19 백신 부스터 조사에 적용Article Published on 2022-08-012022-09-11 Journal: Clinical Trials (London, England) [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, 치료제, [키워드] Analysis antibody tests application approach approval arise booster Booster vaccine booster vaccines can be used Characteristics Clinical efficacy Cluster Combination consequence Contact COVID-19 COVID-19 vaccination detectability disease Effect Efficacy enrolled error evaluate the effect Evidence evidence of feasible flexible framework Guidance HIV HIV prevention incidence Infection infections infectiousness information intervention effect Intervention effects magnitude Molecular epidemiology motivation network network science neutralizing antibody novel populations Pragmatic provide random Randomized randomized trial randomized trials reduce cost Sample size SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 variants Spread Standard of care statistical Study design susceptibility Transmission Trial United Kingdom Vaccine vaccine efficacy variant [DOI] 10.1177/17407745221111818 PMC 바로가기 [Article Type] Article
Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trialClinical Trial Published on 2022-08-012022-10-05 Journal: The Lancet. Haematology [Category] COVID19(2023년), SARS, 임상, 치료제, [키워드] 1:1 95% CI acute COVID-19 adjusted relative risk age Anti-inflammatory effects Antithrombotic antiviral properties assigned assumption Berlin body temperature clinically Control control group COVID-19 criteria death Efficacy eight eligible enoxaparin event rates foundation futility Germany heparin hospitalisation independent initial intention-to-treat population interim analysis investigator-initiated IQR Johanna major bleeding major bleeding event median age multicentre nine not reduce Older older patient Open-label outcome Outpatient parallel-group participant phase 3 trial Prevent Primary outcome Probability prothrombotic randomisation randomised Randomly receive Registered reported respiratory infection respiratory symptom risk Safety Monitoring Board Serious Adverse Event Standard of care statistical Study design study population Switzerland symptomatic Thromboprophylaxis Treatment Trial university University of Zurich was done were recorded with COVID-19 women [DOI] 10.1016/S2352-3026(22)00175-2 PMC 바로가기 [Article Type] Clinical Trial
Expecting individuals’ body reaction to Covid-19 based on statistical Naïve Bayes techniqueResearch article Published on 2022-08-012022-10-05 Journal: Sensors (Basel, Switzerland) [Category] 변종, [키워드] Accuracy affected average binary classification Classifier collected competing complications compose COVID-19 dataset diagnosing drastic Efficiency expectation feature Fisher Gray hybrid Improved include Infection introduced mutated virus Naïve Bayes occur optimization outlier outperform phase Precaution Precision predict prediction provide Prudential Expectation reached recall rejection routine blood test score selected Selection statistical Strategy subset training data virus Wolf Wrapper [DOI] 10.1016/j.patcog.2022.108693 [Article Type] Research article
The unmitigated profile of COVID-19 infectiousnessCOVID-19 전염성의 완화되지 않은 프로필Observational Study Published on 2022-08-012022-09-11 Journal: eLife [Category] SARS, 변종, [키워드] Alpha alpha and delta variants Analysis assumed China Computational biology COVID-19 delta variant early stage early stages Effectiveness Epidemics epidemiological Epidemiology estimate faster framework generation interval global health growth growth rate help Human individual infected individual infected individuals infected with SARS-CoV-2 infectiousness initial intervals Isolation Measures Mitigation outbreak pandemic quarantine quarantine measures robust SARS-CoV-2 sensitivity analysis spread of COVID-19 statistical Systems biology temporal dynamics thought Transmission variants variants of concern VOCs [DOI] 10.7554/eLife.79134 PMC 바로가기 [Article Type] Observational Study