Covariance predicts conserved protein residue interactions important for the emergence and continued evolution of SARS-CoV-2 as a human pathogen공분산은 인간 병원체로서 SARS-CoV-2의 출현과 지속적인 진화에 중요한 보존된 단백질 잔기 상호작용을 예측합니다Article Published on 2022-07-272022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, [키워드] allele alleles Amino acid amino acid residue amino acid residues Analysis approach caused change Combination comprehensive analysis conserved coronavirus CoV CoV genome covariance CoVs difference dominant Epidemics Evolution Evolution of SARS-CoV-2 exhibited followed by Frequency Genome host adaptation human pathogen implicated incrementally independent Interaction Lineage lineages nucleotide occurred Pandemics Pathogens predict Protein protein sequence Region reservoirs residue SARS-CoV-2 SARS-CoV-2 variants statistically unique Viral protein Viral proteins β-coronavirus β-Coronaviruses [DOI] 10.1371/journal.pone.0270276 PMC 바로가기 [Article Type] Article
Immunogenicity evaluation after BNT162b2 booster vaccination in healthcare workers의료 종사자의 BNT162b2 추가 접종 후 면역원성 평가Article Published on 2022-07-262022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] BNT162b2 booster booster vaccination Contact contact with exposure to first vaccination followed by HCW healthcare worker Healthcare workers humoral Humoral response IgA IgA antibodies IgA antibody IgA level IgA levels IgG IgG level IgG levels immune response Immunity immunogenicity implementation increase in Infection Measures new virus pandemic patients Registered restored SARS-COV-2 infection significantly statistically subject the antibody vaccination Vaccine variants virus [DOI] 10.1038/s41598-022-16759-2 PMC 바로가기 [Article Type] Article
Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 20212020년 9월-2021년 12월 영국에서 새롭게 부상하는 SARS-CoV-2 계통의 공간 성장률Article Published on 2022-07-202022-09-11 Journal: Epidemiology and Infection [Category] COVID19(2023년), SARS, 변종, [키워드] addition Alpha Analysis average B.1.1.529 B.1.1.7 B.1.617.2 COG-UK COVD-19 COVID-19 defined Delta England epidemiological faster genomic Genomics Geography growth growth rate identify Lineage lineages Local omicron outbreak robust SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant SARS-CoV-2 variants Spatial analysis statistically Surveillance variant [DOI] 10.1017/S0950268822001285 PMC 바로가기 [Article Type] Article
The Impact of SARS-CoV-2 Pandemic on Patients with Malignant Melanoma at a Romanian Academic Center: A Four-Year Retrospective Analysis루마니아 학술 센터의 악성 흑색종 환자에 대한 SARS-CoV-2 유행병의 영향: 4년 후향적 분석Article Published on 2022-07-122022-09-11 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 치료기술, [키워드] age Analysis Anemia appointments average can not Cancer cancer patient Cancer patients Care comprehensive evaluation COVID-19 COVID-19 disease COVID-19 pandemic database detect determine diagnosed Diagnosis Disease progression Epidemiology Final hospital Impact inclusion criteria increased risk Inpatients limitation lockdown malignant malignant disease malignant diseases Malignant melanoma management Medical care Melanoma outcomes Outpatient outpatients outpatients and inpatient P -value pandemic Patient plastic surgery prevalent proportion required responsible Retrospective analysis risk factor Risk factors Romania SARS-CoV-2 screened severe COVID-19 disease significantly significantly lower skin cancer statistically statistically significant difference study period Treatment [DOI] 10.3390/ijerph19148499 PMC 바로가기 [Article Type] Article
Rapid self-test of unprocessed viruses of SARS-CoV-2 and its variants in saliva by portable wireless graphene biosensor휴대용 무선 그래핀 바이오센서를 통한 타액 내 처리되지 않은 SARS-CoV-2 바이러스 및 그 변이체의 신속한 자가 테스트Article Published on 2022-07-122022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus aptamer biosensor clinically Cognate Concentration coronavirus COVID-19 D614G detect determined by diagnostic DNA domain early phase environmental monitoring epidemiological epidemiologically field-effect transistor Graphene limit limit of detection LoQ MERS Middle East Middle East respiratory syndrome N protein N501Y nucleocapsid omicron pandemic plaque plaque-forming unit platform positive Precision Protein Proteins public health quantitation Rapid RBD Receptor-binding domain respiratory RT-PCR S protein Saliva saliva samples SARS-CoV-2 SARS-CoV-2 variant sensitivity sensor severe acute respiratory syndrome coronavirus 2 significantly lower specificity Spike protein statistically variant variants of concern viral particle Viral particles Viral proteins virus Y453F [DOI] 10.1073/pnas.2206521119 PMC 바로가기 [Article Type] Article
Persistent Symptoms After Acute COVID-19 Infection in Omicron Era오미크론 시대의 급성 COVID-19 감염 후 지속되는 증상Article Published on 2022-07-112022-09-11 Journal: Journal of Korean medical science [Category] 변종, [키워드] Affect age Anxiety blurred vision categories category Clinical characteristics condition conditions coronavirus disease Coronavirus disease 2019 correlated COVID COVID-19 Depression diagnosis of COVID-19 dysfunction Factor fatigue gastrointestinal symptoms greater Hair loss Hypogeusia Hyposmia Intervention multi not different number of symptom observation omicron Omicron variant Patient persistent Post COVID-19 Conditions. Prevalence reported symptom respiratory symptoms sexual dysfunction statistically Symptom Symptoms two group two groups weakness weight loss [DOI] 10.3346/jkms.2022.37.e213 PMC 바로가기 [Article Type] Article
Intravenous IgM-enriched immunoglobulins in critical COVID-19: a multicentre propensity-weighted cohort study중요한 COVID-19에서 정맥내 IgM이 풍부한 면역글로불린: 다기관 성향 가중 코호트 연구Multicenter Study Published on 2022-07-072022-09-12 Journal: Critical Care [Category] COVID19(2023년), SARS, 진단, [키워드] 30-Day mortality acute respiratory distress addition applied Characteristics clinical clinically Cohort cohort study Complication concerning confidence interval controls coronavirus disease COVID-19 COVID-19 patients Cox regression models Critical Critically ill Critically ill patient daily dose dose early administration Effect Efficacy high mortality ICU ICU Patients Immunoglobulin immunoglobulin M immunoglobulins Inflammatory intravenous laboratory-confirmed Lung injury mechanical ventilation mechanically ventilated Mortality multicentre overcome Patient Primary outcome randomization randomized clinical trials retrospective SARS-CoV-2 selection bia statistical significance statistically statistically significant difference subgroup analysis subgroups survival treated Treatment treatment regimen two group was performed Weighting with COVID-19 [DOI] 10.1186/s13054-022-04059-0 PMC 바로가기 [Article Type] Multicenter Study
Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatmentResearch article Published on 2022-07-062022-10-05 Journal: Molecular Therapy [Category] 바이오마커, 변종, 임상, 치료기술, 치료법, [키워드] ACE2 activity/concentration biomarker in plasma/saliva soluble Angiotensin-Converting Enzyme 2 ACE2 acute respiratory syndrome age angiotensin-converting-enzyme Autopsy Biomarker clinical observation Concentration condition Control convalescent Corona virus coronavirus disease Coronavirus-2 COVID-19 COVID-19 disease COVID-19 patient disease disease severity dysregulation evaluate evaluated Hospitalization hospitalized COVID-19 patient human cell infect inverse correlation lung mACE2 marker membrane nadir no difference Non-COVID-19 offer Patient patients plasma Plasma marker plasmas quantitative test quarantine RAS pathway receptor reduced renin-angiotensin system restored sACE2 Saliva saliva marker SARS-CoV-2 SARS-CoV-2 diagnosis/treatment soluble ACE2 statistically therapeutic target tissue treat variations volunteers [DOI] 10.1016/j.omtm.2022.07.003 [Article Type] Research article
Humoral Response to 2-dose BNT162b2 mRNA COVID-19 Vaccination in Liver Transplant Recipients간 이식 환자에서 2회분 BNT162b2 mRNA COVID-19 백신 접종에 대한 체액 반응Article Published on 2022-07-012022-09-11 Journal: Clinical gastroenterology and hepatology : the off [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adult patients age age and sex anti-spike protein IgG antibody Antibody titer Antibody titers BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine Chemiluminescent assay close monitoring Cohort Control control group controls coronavirus correlation correlation coefficients COVID-19 enrolled evaluate evaluated Factor Health care health care workers healthy control healthy controls humoral Humoral response identify immunogenicity Immunosuppression inverse correlation Italian liver liver transplant Liver transplantation median age median value mRNA vaccine multivariable analysis of BNT162b2 Older age Patient patients Protein recipient respiratory response risk S1/S2 SARS-CoV-2 SARS-CoV-2 vaccination significantly statistically Transplant transplantation vaccination Vaccine vaccine administration [DOI] 10.1016/j.cgh.2022.01.012 PMC 바로가기 [Article Type] Article
Public support for unequal treatment of unvaccinated citizens: Evidence from DenmarkRandomized Controlled Trial Published on 2022-07-012022-10-04 Journal: Social science & medicine (1982) [Category] 임상, [키워드] changes in COVID-19 Denmark evaluate experiment General population Government hospital Isolation liberal likelihood pandemic Policy preference provide Public public health raising Randomly reduce Regulation severity significantly Spread statistically Support Treatment Trust vaccinated against COVID-19 vaccination Vaccines virus while [DOI] 10.1016/j.socscimed.2022.115101 PMC 바로가기 [Article Type] Randomized Controlled Trial