Susceptibility to Resurgent COVID-19 Outbreaks Following Vaccine Rollouts: A Modeling StudyArticle Published on 2022-10-122022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] affecting Asymptomatic Characteristics compartmental model conditions contagious country Coverage COVID-19 COVID-19 vaccine COVID-19 vaccines Effect Effectiveness Endemic Epidemics epidemiological expand explain Health help Immunity include initial key factor modeling parameter populations reported resurgent epidemics SARS-CoV-2 SARS-CoV-2 variants Spread susceptibility the disease the SARS-CoV-2 virus the vaccine vaccination vaccination coverage waning immunity [DOI] 10.3390/v14102237 PMC 바로가기
Comparing the B and T cell-mediated immune responses in patients with type 2 diabetes receiving mRNA or inactivated COVID-19 vaccinesArticle Published on 2022-10-112022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome adverse outcome Alpha Anti-RBD IgG BNT162b2 CD4 CD8 cell-mediated immune response cellular Clinical outcome comparable CoronaVac coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 vaccine COVID-19 vaccines diabete dose Effectiveness evaluated first dose healthy individual humoral immune response IgG antibody immune dysfunction Immunological memory immunological memory response Immunological response inactivated Infection influence initial memory mRNA neutralizing antibody neutralizing capacity of BNT162b2 Part Patient platform potential mechanism protective immunity RBD receiving Receptor binding domain reduction in resulting SARS-CoV2 second dose sera susceptibility T cell response T cells T2D Th1 titre Type type 2 diabete type 2 diabetes vaccination vaccinee Vaccines [DOI] 10.3389/fimmu.2022.1018393 PMC 바로가기
Association of Midgut Bacteria and Their Metabolic Pathways with Zika Infection and Insecticide Resistance in Colombian Aedes aegypti PopulationsArticle Published on 2022-10-062022-11-16 Journal: Viruses [Category] 유전자 메커니즘, 치료기술, [키워드] ABC Aede Aedes aegypti affecting Analysis analyzed Bacteria Bacterial Bacteroide changes in Chikungunya Combination condition COVID-19 pandemic Defense Degradation disease Dysbiosis effective evaluated female females function functions generate Honda Host identify Infection infection control infection rate infections infective insecticide insecticides Interaction intestinal intestine knowledge lack lambda-cyhalothrin limitation Local management mechanism metabolic metabolism microbiota microcephaly midgut midgut. modulated Mutation natural infection outbreak pathogenicity Population populations predict predicted prenatal Pseudomona resistance risk RT-PCR significantly sodium South America Surveillance susceptibility susceptible syndrome Transmission Treatment Vaccine vector control Viral transmission virus entry was related Zika Zika virus ZIKV [DOI] 10.3390/v14102197 PMC 바로가기
Coronavirus Host Genomics Study: South Africa (COVIGen-SA)Article Published on 2022-10-062022-11-15 Journal: Global health, epidemiology and genomics [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] African black build coronavirus COVID-19 develop ENhance Factor female Genetic genetic information genome-wide association genomic Genomics genomics study Host Host genetic factor loci modify outcome over pandemic participant populations positive promote recruited Research resource risk factor SARS-CoV-2 Sequencing severe disease severity South South Africa susceptibility with COVID-19 with HIV [DOI] 10.1155/2022/7405349 PMC 바로가기
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variantsArticle Published on 2022-10-062022-11-16 Journal: Cell Stem Cell [Category] COVID19(2023년), SARS, 변종, [키워드] cause Cell Cluster Dengue dengue virus disease-associated functional variant genome-wide association Genome-wide association study GWAS Human genetics identify indicated individuals Infection iPSC array isogenic hiPSC lines leakage of mtDNA locus Loss mitochondrial mtDNA NDUFA4 non-risk allele polymorphism provide risk risk allele SARS-CoV-2 SARS-COV-2 infection screening strategy sensitivity Signaling single-nucleotide single-nucleotide polymorphism SNP SNPs Stress susceptibility type I interferon upregulation viral infection viral infectivity virus Zika virus ZIKV [DOI] 10.1016/j.stem.2022.09.008 PMC 바로가기
Divergent SARS-CoV-2-specific T cell responses in intensive care unit workers following mRNA COVID-19 vaccinationArticle Published on 2022-10-062022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome analyzed antibody CD4 CD4+ CD4+ T cells CD8 CD8+ CD8+ T cells Cellular immune response competent coronavirus COVID-19 COVID-19 vaccination develop dose elicited ELISPOT exhibited had no healthy individuals humoral ICU immune protection immune response individual individuals information intensive care intensive care unit workers lack maintain mRNA mRNA COVID-19 vaccines mRNA vaccine neutralizing antibody proportion Protein protein S reactive receiving reduction in SARS-CoV-2 SARS-CoV-2-specific T cell Seroconversion seronegative Specific T-cell response susceptibility T cell T cell response T cells T lymphocyte T-cell the S protein the SARS-CoV-2 the spike protein vaccination viral infection Viral protein [DOI] 10.3389/fimmu.2022.942192 PMC 바로가기
Immunogenicity, Safety, and Anti-Viral Efficacy of a Subunit SARS-CoV-2 Vaccine Candidate in Captive Black-Footed Ferrets ( Mustela nigripes) and Their Susceptibility to Viral ChallengeArticle Published on 2022-10-042022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Affect Anti-viral Antibody Response Antibody titer black-footed ferrets candidate challenge clinical disease correlated declined Efficacy experimental challenge ferret highest Human immunogenicity in vitro in vivo increase in indicate lack lung viral load mice morbidity Mortality mustelids pathogen populations potential risk pre-vaccination produced Protein purified Safety SARS-CoV-2 SARS-CoV-2 S1 serum subunit susceptibility transfer Trial unlikely upper respiratory tract vaccination vaccinees viral replication was determined [DOI] 10.3390/v14102188 PMC 바로가기
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
Understanding COVID-19 susceptibility and presentation based on its underlying physiologyEditorial Published on 2022-10-012023-07-09 Journal: Physiological reviews [Category] COVID19(2023년), [키워드] macrophages metabolites Pregnancy SARS-CoV2 susceptibility [DOI] 10.1152/physrev.00008.2022 PMC 바로가기 [Article Type] Editorial
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesisArticle Published on 2022-10-012022-11-16 Journal: Experimental & Molecular Medicine [Category] 변종, 유전자 메커니즘, [키워드] Analysis ChIP chromatin chromatin architecture classical monocytes clinical impact COVID-19 dissect element exacerbating exhibited facilitate Gene Expression gene expression signature Hematopoiesis highlight hyperinflammation IFN-γ immunological individual Inflammation inflammatory immune response Inflammatory responses interactions mechanism methylated mononuclear cells Patient Peripheral blood putative target gene Region Regulatory reported severe COVID-19 severe COVID-19 patients severity single-cell susceptibility Transcriptome with COVID-19 [DOI] 10.1038/s12276-022-00866-1 PMC 바로가기