DrugDevCovid19: An Atlas of Anti-COVID-19 Compounds Derived by Computer-Aided Drug DesignDrugDevcovid19 : 컴퓨터 보조 약물 설계에 의해 유래 된 항 코비드 -19 화합물의 아틀라스Review Published on 2022-01-212022-08-31 Journal: Molecules [Category] 신약개발, 치료제, [키워드] analyses analyzed Atla bioinformatics Compound computer-aided drug design COVID-19 COVID-19 therapeutics database docking drug drug design facilitate feature Neck organized outbreak performed SARS-CoV-2 structures subsequent target protein these compounds valuable resource [DOI] 10.3390/molecules27030683 PMC 바로가기 [Article Type] Review
PROTAC targeted protein degraders: the past is prologue Reviews Published on 2022-01-182022-10-05 Journal: Nature Reviews Drug Discovery [Category] 신약개발, 치료제, [키워드] Cancer clinical development Degradation degrade disease-causing oncology Precision Protein provided reported review Small molecules target target protein therapeutic ubiquitin ligase [DOI] 10.1038/s41573-021-00371-6 [Article Type] Reviews
Comparative Immunogenicity of the Recombinant Receptor-Binding Domain of Protein S SARS-CoV-2 Obtained in Prokaryotic and Mammalian Expression SystemsArticle Published on 2022-01-092022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Analysis Antibody titer antigenic BALB/c mice cells CHO cell Comparative COVID-19 domain effective ELISA expressed expression humoral immune response immunized immunogenic immunogenicity maintain mammalian mice neutralization neutralizing antibody Protein protein S provide RBD Receptor-binding domain recombinant recombinant RBD protein S protein SARS-CoV-2 sera significantly subunit vaccines System target target protein the RBD Vaccine variant [DOI] 10.3390/vaccines10010096 PMC 바로가기 [Article Type] Article
An update of anti-viral treatment of COVID-19COVID-19의 항바이러스 치료 업데이트Review Published on 2021-12-172022-09-10 Journal: Turkish Journal of Medical Sciences [Category] SARS, 치료제, [키워드] ACE-2 Administered Anti-viral treatment Antiviral AT-527 biological processe biological processes bromhexine camostat clinical trial clinical trials convalescent plasma COVID-19 drug dutasteride early phase effective effective antiviral treatment evaluated Favipiravir fluvoxamine group Host host protein host proteins human cell Hydroxychloroquine include inhibitor inhibitors interfere interferons Ivermectin knowledge Laboratory lactoferrin Lopinavir Lopinavir/ritonavir merimepodib molnupiravir moment monoclonal antibodies monoclonal antibody nanobodies natural immunity niclosamide nitazoxanide pandemic PF-07304814 PF-07321332 Plitidepsin protease Protein Proteins proxalutamide PTC299 RCTs Remdesivir Result Ritonavir RNA SARS-CoV-2 subject Support target protein target proteins the disease to define Treatment treatment for COVID-19 treatment of COVID-19 Trial umifenovir Viral viral entry Viral RNA virus [DOI] 10.3906/sag-2106-250 PMC 바로가기 [Article Type] Review
A Dispersion Corrected DFT Investigation of the Inclusion Complexation of Dexamethasone with β-Cyclodextrin and Molecular Docking Study of Its Potential Activity against COVID-19β-Cyclodextrin과 Dexamethasone의 포함 복합체에 대한 분산 수정 DFT 조사 및 COVID-19에 대한 잠재적 활성에 대한 분자 도킹 연구Article Published on 2021-12-152022-09-10 Journal: Molecules [Category] SARS, 치료제, [키워드] β-cyclodextrin 6LU7 active site active sites activity approach AutoDock AutoDock vina binding Bioavailability calculated Cavity characterization complex complexation computation COVID-19 Density functional theory Dexamethasone DFT-D4 dispersion encapsulation ENhance free energy functional hydrogen Hydrogen bond hydrogen bonds inhibitor inhibitory activity Interaction investigated investigation molecular docking Molecular docking study non-covalent interactions PDB PDB ID PDB ID: 6LU7 Potential predicted protease Protease inhibitor Protein reducing SARS CoV-2 Side effects significantly target protein therapeutic activity van der Waal van der Waals interactions was performed [DOI] 10.3390/molecules26247622 PMC 바로가기 [Article Type] Article
Thiol-sensitive probe enables dynamic electrochemical assembly of serum protein for detecting SARS-Cov-2 marker protease in clinical samples티올에 민감한 프로브는 임상 샘플에서 SARS-Cov-2 마커 프로테아제를 검출하기 위한 혈청 단백질의 동적 전기화학적 조립을 가능하게 합니다.Article Published on 2021-12-152022-09-11 Journal: Biosensors & bioelectronics [Category] SARS, 치료기술, 치료제, [키워드] Clinical practice clinical sample Concentration COVID-19 fluorescent incorporation Incubation induce infected patient infected patients Interaction main protease marker mimicking molecule network nucleic acid Nucleic acid detection peptide Peptide nano-network probe protease Protein Region SARS-CoV-2 sensitivity serum Serum protein serum samples spreading target target protein thiol thiol group Thiol probe. virus virus assay while [DOI] 10.1016/j.bios.2021.113579 PMC 바로가기 [Article Type] Article
Production of full-length SARS-CoV-2 nucleocapsid protein from Escherichia coli optimized by native hydrophobic interaction chromatography hyphenated to multi-angle light scattering detection다각도 광산란 검출에 하이픈으로 연결된 천연 소수성 상호작용 크로마토그래피에 의해 최적화된 대장균으로부터 전장 SARS-CoV-2 뉴클레오캡시드 단백질 생산Article Published on 2021-12-012022-09-11 Journal: Talanta [Category] SARS, 치료기술, 치료법, 치료제, [키워드] abundantly expressed acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis analytical method Cell cell lysis chaperone Chromatography complementary coronavirus cpCasp2‐based platform fusion protein process (CASPON technology). Critical diagnostic dimerized downstream Downstream processing (DSP) DSP E. coli enhanced enzyme-linked immunosorbent enzyme-linked immunosorbent assay Escherichia coli explained fermentation fraction full-length SARS-CoV-2 fusion protein host cell hydrophobic Hydrophobic interaction chromatography-multi-angle light scattering (HIC-MALS) Infection information Interaction life cycle mass spectrometry minor molecular MONITOR novel Novel coronavirus Novel coronavirus (termed SARS-CoV-2) Nuclease nucleic acids nucleocapsid protein nucleoprotein peptide platform produced Production Protein protein expression purification purified purity resolving power SARS-CoV-2 scattering SEC selectivity sequence severe acute respiratory syndrome Coronavirus target protein Treatment variable viral life cycle was used were expressed yield [DOI] 10.1016/j.talanta.2021.122691 PMC 바로가기 [Article Type] Article
Site-Specific Labeling of Endogenous Proteins Using CoLDR ChemistryArticle Published on 2021-11-242022-10-29 Journal: Journal of the American Chemical Society [Category] Coronavirus, SARS, [키워드] addition Affect approach binding binding pocket BTK Cell cells Chemical Chemistry CRBN Degradation demonstrated endogenous fluorescent functional inhibit interactions labeling Ligand maintain Modification MONITOR probe Protein quantification SARS-CoV-2 selective shown stability target protein variety [DOI] 10.1021/jacs.1c06167 PMC 바로가기 [Article Type] Article
Cosolvent and Dynamic Effects in Binding Pocket Search by Docking SimulationsArticle Published on 2021-11-032022-10-29 Journal: Journal of Chemical Information and Modeling [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome addition binding free energy binding site classical Clustering Combination conformational conformational change coronavirus criteria docking docking result drug Drug discovery dynamic Effect Efficacy ENhance expected food IMPROVE inefficient lack Ligand Local molecular performed pocket probe Protein provided RdRP RNA-dependent RNA polymerase SARS-CoV-2 Simulation solvent Structure target protein Trajectories United State Virtual screening [DOI] 10.1021/acs.jcim.1c00924 PMC 바로가기 [Article Type] Article
Selection for constrained peptides that bind to a single target proteinArticle Published on 2021-11-032022-10-29 Journal: Nature Communications [Category] COVID-19, MERS, SARS, [키워드] adhere Antibiotics bind binding build diagnostics E. coli enzyme Escherichia coli expression functions identify in vivo microbial Natural product synthesis pathway peptide produced Protein Receptor binding domain RNA polymerase Secondary Metabolite Selection Signaling spike Synthetic biology target protein the SARS-CoV-2 was performed [DOI] 10.1038/s41467-021-26350-4 PMC 바로가기 [Article Type] Article