Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small MoleculesSARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지Review Published on 2022-05-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus [DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review
Pearson’s patterns correlational of clinical risks at admissions with hospitalization outcomes during initial COVID-19 outbreakResearch article Published on 2022-05-182022-10-05 Journal: iScience [Category] 바이오마커, 신약개발, 임상, [키워드] absence Admission Analysis Aspartate aminotransferase AST Clinical finding clinical parameter clinical risk Cohort conducted correlated COVID-19 outbreak death dysregulated Guidance Health Sciences healthcare Healthcare systems Hospitalization hospitalized patient independent initial lactate dehydrogenase LDH Mortality neutrophil neutrophil count Outbreaks outcome patients with COVID-19 retrospective cohort study risk factor targeted therapy with COVID-19 [DOI] 10.1016/j.isci.2022.104415 [Article Type] Research article
Pathogenesis of Alcohol-Associated Liver DiseaseReview article Published on 2022-05-012022-10-05 Journal: Journal of Clinical and Experimental Hepatology [Category] 비임상, [키워드] absorbed alcohol Alcohol-associated liver disease cause circulation clinical consequences death disease disorder disrupt ethanol metabolism gastrointestinal tract global healthcare liver Liver disease mechanism metabolism multifactorial organ function Pathogenesis pathophysiology prevalent regimen Research Stage targeted therapy tissue treat while [DOI] 10.1016/j.jceh.2022.05.004 [Article Type] Review article
Understanding the lived experience of lung cancer: a European social media listening studyObservational Study Published on 2022-04-302022-10-05 Journal: BMC Cancer [Category] 임상, [키워드] Algorithm Analysis analyzed approach automated Cancer Cell Chemotherapy Clinical endpoints collected COVID-19 dataset Delay disease distress effective European filtered Final generate hcp Healthcare professional highest Immunotherapy increasingly information lack lung lung cancer lung cancer patient majority manual media Neutral Non-small cell lung cancer outcome Patient Patient journey physician platform provide Quality Quality of life Real-world evidence Side effects social media Social media listening. survival targeted therapy the patient Topic Treatment understanding unmet need [DOI] 10.1186/s12885-022-09505-4 PMC 바로가기 [Article Type] Observational Study
Bioinformatics and System Biology Approach to Identify the Influences of COVID-19 on Rheumatoid Arthritis류마티스 관절염에 대한 COVID-19의 영향을 식별하기 위한 생물정보학 및 시스템 생물학 접근Article Published on 2022-04-072022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Analysis approach Arthritis association bioinformatics Biology candidate drug condition coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients dataset datasets DEGs differentially expressed differentially expressed gene Differentially expressed genes drug drug molecule functional functional enrichment generate hub genes identify Infection influence interactions mechanism molecular mechanism molecular mechanisms Mortality ontological Pathway analysis performed potential molecular PPI PPI network progression protein-protein interaction proteinprotein interaction rapid increase Rheumatoid rheumatoid arthritis SARS-CoV-2 screened severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe coronavirus disease statistical System Systems biology targeted therapy Transcription transcription factor Treatment were used [DOI] 10.3389/fimmu.2022.860676 PMC 바로가기 [Article Type] Article
SARS-CoV-2 origin, myths and diagnostic technology developmentsReview Published on 2022-03-042022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] accelerated approach assays baseline Body caused China COVID-19 CRISPR Culture Diagnosis diagnostic Diagnostic method diagnostics drug resistance Effect ELISA epidemiological evaluated Factor False negative Future Genome Healthcare systems implication information Intervention isothermal amplification knowledge Laboratory LAMP less management morbidity myth pandemic paucity of data profile provided reducing repeated reported RT-PCR SARS-CoV-2 SARS-CoV-2 virus sensitivity specificity targeted therapy the patient TMA Treatment virus virus genome WHO World Health Organization Zika virus [DOI] 10.1186/s43042-022-00255-3 PMC 바로가기 [Article Type] Review
The impact of anti-tumor approaches on the outcomes of cancer patients with COVID-19: a meta-analysis based on 52 cohorts incorporating 9231 participantsResearch Published on 2022-03-042022-10-28 Journal: BMC Cancer [Category] COVID-19, MERS, SARS, [키워드] 95% confidence interval addition adopted age Analysis Anti-tumor therapy approach approaches Cancer cancer patient Chemotherapy CIs Cohort COPD COVID-19 COVID-19 diagnosis database death Endocrine Gender hypertension identify Immunotherapy incidence indicated individual lung cancer Meta-analysis Odds ratio outcome participant primary endpoint Prognostic factor Prognostic factors Radiotherapy raised Result risk risk of death searched severe COVID-19 severe disease smoking solid tumor stratified subgroup analysis supplementary material targeted therapy therapy treated trials with COVID-19 [DOI] 10.1186/s12885-022-09320-x PMC 바로가기 [Article Type] Research
A Feasible Alternative Strategy Targeting Furin Disrupts SARS-CoV-2 Infection Cycle푸린을 표적으로 하는 실행 가능한 대안 전략은 SARS-CoV-2 감염 주기를 방해합니다Research Article Published on 2022-02-092022-09-10 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] ACE2 Activation addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antibodies antibody Antibody Response applicability approach binding blockade Cell cellular entry chain cleavage competing coronavirus COVID-19 Critical cycle described disease pathology DNA domain effective Efficacy epitope flexible linker furin Health Hospitalization Host host cell host cells host protease human lung cell human lung cells IgG1 Immunological memory in viral independent Infection infection cycle infections interfere lung cells membrane fusion Mortality occur overcome peptide plug processing producing protease Proteases proteolytic activation Proteolytic processing public health threat remained remains uncertain residue RNA SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viral particles scenario secretory pathway solution spike glycoprotein Spike protein Strategy subsequent targeted therapy targeting the spike protein Transmission Vaccine Viral viral entry Viral transmission virus virus-producing cell virus-producing cells viruses [DOI] 10.1128/spectrum.02364-21 PMC 바로가기 [Article Type] Research Article
Immunogenicity and Safety of the BNT162b2 mRNA COVID-19 Vaccine Among Actively Treated Cancer Patients적극적으로 치료받는 암 환자 중 BNT162b2 mRNA COVID-19 백신의 면역원성과 안전성Article Published on 2022-02-072022-09-12 Journal: Journal of the National Cancer Institute [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activity Adults adverse effect antibody Antibody titer anticancer BNT162b2 mRNA BNT162b2 vaccine Cancer cancer patient Chemotherapy combinations conducted control group COVID-19 Cutoff determine dose effective greater healthy immune Immune checkpoint inhibitor immunogenicity Immunoglobulin measure medication MOST Patient patients Patients with cancer proportion Protective questionnaire reported Retrospective study Safe Safety SARS-CoV-2 seronegative seropositive Side effect significantly significantly lower solid tumor statistical test statistically targeted therapy the SARS-CoV-2 titer treated treated patient Treatment vaccination Vaccine was collected were measured [DOI] 10.1093/jnci/djab174 PMC 바로가기 [Article Type] Article
CTCFL regulates the PI3K-Akt pathway and it is a target for personalized ovarian cancer therapyArticle Published on 2022-02-072022-10-04 Journal: NPJ Systems Biology and Applications [Category] 바이오마커, [키워드] ACTBL2 Biomarker Biomarkers Cancer candidate Characteristics Combination Computational biology and bioinformatics CTCF CTCFL cytoplasmic membrane de novo Diagnosis driving effective enrichment analysis evaluate expressed females function HGSC High-grade Improving in vitro model involved ITGB3 ITGB6 lack malignancy MALT1 molecular ovarian ovarian cancer Pathomechanism pathway PCDH7 predict prognostic Prognostic marker progression regulate Regulatory resulting survival target target gene targeted therapy targets therapeutic potential therapy tissue transcriptional transcriptional change Treatment VEGFA [DOI] 10.1038/s41540-022-00214-z PMC 바로가기 [Article Type] Article