Coronavirus-Induced Host Cubic Membranes and Lipid-Related Antiviral Therapies: A Focus on Bioactive PlasmalogensCell and Developmental Biology Published on 2021-03-122022-10-31 Journal: Frontiers in Cell and Developmental Biology [Category] COVID-19, [키워드] alteration Anti-viral antiviral therapy Biomarker cardiometabolic disorder coronavirus Coronavirus infection correlation COVID-19 COVID-19 patients cubic cubic membrane deficiency enzyme ether focus host cell host cells humans IMPROVE infected individuals Infection lipid metabolism lung membrane membrane fusion membrane-bound protein membranes MERS-CoV Modification modulate obesity organism Patient plasmalogen Prophylactic provoke receptors Replication required SARS-CoV SARS-CoV-2 SARS-CoV-2 infections severity suggested susceptibility TEM therapeutic Treatment type 2 diabete Virus-host interaction [DOI] 10.3389/fcell.2021.630242 PMC 바로가기 [Article Type] Cell and Developmental Biology
A Novel Computational Approach for the Discovery of Drug Delivery System Candidates for COVID-19COVID-19에 대한 약물 전달 시스템 후보 발견을 위한 새로운 전산 접근 방식Article Published on 2021-03-102022-09-10 Journal: International Journal of Molecular Sciences [Category] 신약개발, [키워드] Algorithm approach CADD candidate Clustering computer-aided drug discovery condition coronavirus disease Coronavirus disease 2019 COVID-19 delivery docking drug drug delivery system Efficacy evaluated functional functional group glycyrrhizin IMPROVE in silico information machine learning micelle nanoparticles molecular molecules morphology nafamostat Nafamostat mesilate novel predicted Schrodinger stability System TEM transmission electron microscopy treat unsupervised learning was selected zeta potential [DOI] 10.3390/ijms22062815 PMC 바로가기 [Article Type] Article
Evaluation of the Antiviral Activity of Sitagliptin-Glatiramer Acetate Nano-Conjugates against SARS-CoV-2 VirusArticle Published on 2021-02-242022-10-28 Journal: Pharmaceuticals [Category] COVID-19, [키워드] 1:1 3CL 3CL Protease Acetate activity acute respiratory syndrome addition Antiviral binding affinity carried cause cellular characterization China Clinical efficacy clinical study complex component Concentration coronavirus Coronavirus replication COVID COVID-19 COVID-19 pandemic criteria docking Efficacy epithelial cell evaluate factorial design Factors FDA-approved drugs Glatiramer acetate half-maximal inhibitory concentration Health IC50 investigated Nanoparticles outbreak Prevent protease protease inhibition required responses SARS-CoV-2 selected shown sitagliptin target cell TEM the SARS-CoV-2 virus transmission electron microscopy treat VERO-E6 virus were assessed [DOI] 10.3390/ph14030178 PMC 바로가기 [Article Type] Article
A cross-talk between epithelium and endothelium mediates human alveolar–capillary injury during SARS-CoV-2 infection상피와 내피 사이의 혼선은 SARS-CoV-2 감염 동안 인간의 폐포-모세혈관 손상을 중재합니다Article Published on 2020-12-082022-09-11 Journal: Cell Death & Disease [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] affected alveolar epithelial cells alveolar epithelium Analysis attack autophagy cause caused change changes in co-culture contributed COVID-19 cross-talk damage disease elicited Endothelial cell endothelial cells Endothelium epithelial cell epithelial cells epithelium expand Health Health crisis host cells inhibit inhibitor Injury leads Lung infection Mechanisms of disease mitochondrion modulation molecular basis organelle pandemic Protein proteomic response SARS-CoV-2 SARS-COV-2 infection TEM Viral viral infection virus replication while [DOI] 10.1038/s41419-020-03252-9 PMC 바로가기 [Article Type] Article
The Strengths of Scanning Electron Microscopy in Deciphering SARS-CoV-2 Infectious CycleMicrobiology Published on 2020-08-192022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] Cell cell lysis cells classical comparable Complete complex contributed coronavirus cycle Diagnosis electron electron microscopy electronic microscopy expelled helping infectious cycle membrane fusion Microscopy New Particle Patient plasma membrane Post-infection powerful tool public health Replication SARS-CoV SARS-CoV-2 SARS-CoV-2 particle scanning scanning electron microscopy SEM significantly strength TEM Transmission Vero E6 cell VERO E6 cells viral infections virus [DOI] 10.3389/fmicb.2020.02014 PMC 바로가기 [Article Type] Microbiology
Construction and Immunogenicity of Novel Chimeric Virus-Like Particles Bearing Antigens of Infectious Bronchitis Virus and Newcastle Disease VirusArticle Published on 2019-03-132022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] affecting antigens Bearing bivalent vaccine bronchitis cellular immune responses chimeric chimeric virus-like particles Complete construction cytokine death disease domain dose ectodomain ELISA evaluate humoral IBV IFN-γ IL-4 immunized immunogenic immunogenicity indicated induce Infectious Bronchitis Virus M protein Microscope morphology newcastle disease virus novel Particle pathogen Protein provided reduced Result S protein specific antibody specific pathogen-free SPF Swab T cell TEM tissue Transmission vaccination Vaccine vaccine candidate vaccine platform Viral RNA virulent virus Virus-like particle VLP VLPs [DOI] 10.3390/v11030254 PMC 바로가기 [Article Type] Article
Single-step biological fabrication of colloidal silver nanoparticles using Hugonia mystax: larvicidal potential against Zika virus, dengue, and malaria vector mosquitoesArticle Published on 2017-11-302024-09-09 Journal: Artif Cells Nanomed Biotechnol [Category] 말라리아, [키워드] Dengue FTIR green synthesis mosquito-borne diseases nanocomposite. SEM TEM XRD PMC 바로가기
Porcine Hemagglutinating Encephalomyelitis Virus Enters Neuro-2a Cells via Clathrin-Mediated Endocytosis in a Rab5-, Cholesterol-, and pH-Dependent MannerVirus-Cell Interactions Published on 2017-09-272022-10-30 Journal: Journal of Virology [Category] Coronavirus, [키워드] Actin activated Activation Analysis antiviral drug approach cause Cell cells cellular entry Central nervous system China cholesterol clathrin Clathrin-mediated endocytosis CNS confocal microscopy contagious coronavirus death disease dissect dominant negative dysfunction Encephalomyelitis endocytic pathways endocytosis etiological agent Exocytosis GTPase Guidance Host infected cell Infection Invasion investigated involved knowledge mechanism molecular mechanism mutant nerve cell Neural neurological neurovirulent neurovirulent coronavirus occur overexpression Pathogenesis pathway performed pharmacological porcine hemagglutinating encephalomyelitis virus positive-sense positively correlated progression Rab required RNA coronavirus RNA interference single-stranded suggested target TEM Therapeutic strategies transfer transmission electron microscopy understanding viral endocytosis viral entry viral entry pathway virus virus particles were used [DOI] 10.1128/JVI.01083-17 PMC 바로가기 [Article Type] Virus-Cell Interactions
Characterization of E-type colicinogenic plasmids from Shigella sonneiShigella sonnei에서 E형 콜리시닌 생성 플라스미드의 특성화Article Published on 2017-04-012024-08-22 Journal: FEMS Microbiology Letters [Category] 세균성이질, [키워드] colicin Escherichia coli PCN Plasmid Shigella sonnei TEM
Clinical and Microbiological Profiles of Shigellosis in Children소아의 시겔라증의 임상 및 미생물학적 프로필Article Published on 2014-12-012024-07-30 Journal: Journal of Health, Population, and Nutrition [Category] 세균성이질, [키워드] children CTX-M ESBL Shigellosis TEM virulence genes PMC 바로가기