transcriptomic – Page 5 – Communicable Diseases Research

Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected Mice

SARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체

Article

Published on 2022-06-242022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술,

Host protease activity classifies pneumonia etiology

숙주 프로테아제 활성은 폐렴 병인을 분류합니다

Article

Published on 2022-06-212022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] 치료기술, 치료제,

Single-cell transcriptomic profiling of lung endothelial cells identifies dynamic inflammatory and regenerative subpopulations

폐 내피 세포의 단일 세포 전사체 프로파일링은 동적 염증 및 재생 하위 집단을 식별합니다

Article

Published on 2022-06-082022-09-11
Journal: JCI Insight [Category] COVID19(2023년), SARS, 신종인플루엔자, 유전자 메커니즘,

[키워드] Activation Bacterial infections baseline Cell Clustering defined demonstrated division endothelial endothelial cells Endothelium expression Gene Expression H1N1 H1N1 influenza H1N1 influenza virus heterogeneity identify immune response gene immune response genes increased expression infected with SARS-CoV-2 Infectious disease Inflammatory inflammatory lung injury inflammatory signaling Influenza Injury labor limit LPS lung lung endothelial Lung injury MHC gene MHC genes murine organ overexpression Pathway analysis performed phenotypic prevented proliferative promote Pulmonology regeneration regenerative respond Seurat single-cell single-cell RNA-seq Sox17 subpopulation targeted therapy transcriptomic Vascular vascular bed vascular endothelial cell vascular endothelial cells virus
[DOI] 10.1172/jci.insight.158079 PMC 바로가기 [Article Type] Article

Lung Spatial Profiling Reveals a T Cell Signature in COPD Patients with Fatal SARS-CoV-2 Infection

폐 공간 프로파일링은 치명적인 SARS-CoV-2 감염이 있는 COPD 환자의 T 세포 서명을 나타냅니다

Article

Published on 2022-06-072022-09-11
Journal: Cells [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] airways Antigen CD4 CD45 CD45RO Cell characterized chronic obstructive chronic obstructive pulmonary disease chronic obstructive pulmonary disease (COPD) chronic obstructive pulmonary disease (COPD). COPD COVID-19 COVID-19 infection death died downregulation expression Gene Expression immune microenvironment immune response invasive lung Lung disease Lung diseases lung parenchyma memory memory T memory T cell obstructive pulmonary disease parenchyma Patient patients priming Profiling Protein proteomic pulmonary disease receptor ROI ROIs SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 disease 2019 SARS-CoV-2 entry SARS-COV-2 infection sick signature significant enrichment Smokers Still structural gene T cell T cell response T cells T-lymphocyte T-lymphocytes transcriptomic underlie vessel vessels with COVID-19
[DOI] 10.3390/cells11121864 PMC 바로가기 [Article Type] Article

A systems biology approach identifies candidate drugs to reduce mortality in severely ill patients with COVID-19

시스템 생물학 접근 방식으로 COVID-19 중증 환자의 사망률을 줄이기 위한 후보 약물 식별

Article

Published on 2022-06-032022-09-11
Journal: Science Advances [Category] COVID19(2023년), SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus applied approach attribute candidate candidate drug caused coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID-19 Critically ill Critically ill patient critically ill patients drug target drug treatment effective Epigenetic Hospital admission host response identify interferon interferon signaling lack Messenger RNA metabolism monocyte Mortality Nintedanib Ordinal Scale pathway Pathways Patient patients hospitalized reduce mortality RNA splicing SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severely ill patient severely ill patients Systems biology tacrolimus therapeutic transcriptomic Treatment Vaccines with COVID-19 Zotatifin
[DOI] 10.1126/sciadv.abm2510 PMC 바로가기 [Article Type] Article

Integration of omics data to generate and analyse COVID-19 specific genome-scale metabolic models

omics 데이터를 통합하여 COVID-19 특정 게놈 규모 대사 모델 생성 및 분석

Article

Published on 2022-06-012022-09-11
Journal: Computers in biology and medicine [Category] 바이오마커, 유전자 메커니즘, 치료제,

[키워드] addressed analyses Analysis Antiviral applied approach cholesterol cholesterol metabolism code Combination complex Context-specific models COVID-19 COVID-19 patients dataset datasets disease down-regulated downregulated downregulation enrichment FIVE generate genome-scale metabolic models host response include indicated Infection integration MEM metabolic Metabolic enrichment analysis metabolic pathway metabolic pathways metabolism Model Model extraction methods. observation observations predicted prediction preserved Previous studies previous study produced provided retinol separated targets transcriptomic Variability Vitamin D3
[DOI] 10.1016/j.compbiomed.2022.105428 PMC 바로가기 [Article Type] Article

The interplay between lncRNAs, RNA-binding proteins and viral genome during SARS-CoV-2 infection reveals strong connections with regulatory events involved in RNA metabolism and immune response

SARS-CoV-2 감염 동안 lncRNA, RNA 결합 단백질 및 바이러스 게놈 사이의 상호 작용은 RNA 대사 및 면역 반응과 관련된 조절 사건과의 강력한 연결을 보여줍니다

Article

Published on 2022-05-092022-09-11
Journal: Theranostics [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyzed association BISPR Cell cellular cellular response characterized Cohort cohort of patient Combination complex component composed connection coronavirus Correlation analysis Defense defense mechanisms determine element event experimental evidence FMR1 FMR1-IT1 functional Host host cells human host cell human host cells human RNA identify immune response in silico infected cell Infection infectious agent Interaction interactions interferon interferon response intrinsic involved lncRNA long non-coding RNA mechanism metabolism MIR155HG modulate molecular ncRNAs Non-coding RNAs NRIR performed progression Protein rationale Regulation Regulatory regulatory network regulatory network. replicative reveal RNA RNA viruses RNA-binding protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral load sequestering Specific Surveillance the interferon transcriptional transcriptomic triggered USP30 USP30-AS1 Viral viral genome viral infections viral RNA genome
[DOI] 10.7150/thno.73268 PMC 바로가기 [Article Type] Article

Key benefits of dexamethasone and antibody treatment in COVID-19 hamster models revealed by single-cell transcriptomics

COVID-19 햄스터 모델에서 덱사메타손 및 항체 치료의 주요 이점, 단일 세포 전사체로 밝혀짐

Article

Published on 2022-05-042022-09-11
Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, 치료법, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus Analysis analyzed Anti-inflammatory anti-inflammatory effect anti-inflammatory properties anti-inflammatory property anti-SARS-CoV-2 antibody Anti-viral anti-viral effect anti-viral effects antibodies antibody antibody treatment benefit Cell combination therapy coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 treatment Dexamethasone disease drugs Effect effective Efficacy exhibited hamster host responses immune responses Immunity Infection Inflammatory inflammatory cell lung Lungs mechanisms monoclonal antibody monoclonal antibody therapy Neutrophils potential mechanism prevented pulmonary pulmonary immune response recruitment respiratory SARS-CoV-2 scRNA-seq severe disease single-cell Standard-of-care subpopulation synergistic synergistic effects therapeutic option therapeutic options Therapies therapy transcriptomic transcriptomics Treatment Vaccine vaccine efficacy Vaccine hesitancy variants Viral viral burden was reduced
[DOI] 10.1016/j.ymthe.2022.03.014 PMC 바로가기 [Article Type] Article

Genetic Landscape of the ACE2 Coronavirus Receptor

ACE2 코로나바이러스 수용체의 유전적 지형

Meta-Analysis

Published on 2022-05-032022-09-11
Journal: Circulation [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술,

[키워드] ACE2 ACE2 protein Analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 biological systems blood immune cells cardiometabolic cardiovascular disease cardiovascular diseases cardiovascular diseases. Cell cell type circulating Clinical studies clinical study Combined complex complex disease conducted coronavirus correlated correlation COVID-19 COVID-19 severity cross-sectional Diseases DNA methylation elevated epidemiological epigenomic expressed functional gastrointestinal tracts Genetic genetic architecture Genome genome-wide association Genome-wide association study heart heritability Hospitalization Human human cell human cells immune cells in silico individual Infection landscape likelihood loci mapped medications mendelian randomization Meta-analysis Odds ratio outcome Phenotypes plasma Protein Quantitative randomization receptor Regulatory related diseases resource respiratory SARS-CoV-2 severe COVID-19 soluble ACE2 suggested tissue transcriptomic Treatment variant Vascular vascular disease vascular diseases
[DOI] 10.1161/CIRCULATIONAHA.121.057888 PMC 바로가기 [Article Type] Meta-Analysis

Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus

Research

Published on 2022-04-152022-10-05
Journal: Genes and Immunity [Category] 바이오마커,