upstream – Page 5 – Communicable Diseases Research

COVID-19-Associated Pulmonary Aspergillosis, Fungemia, and Pneumocystosis in the Intensive Care Unit: a Retrospective Multicenter Observational Cohort during the First French Pandemic Wave

Observational Study

Published on 2021-10-202022-10-04
Journal: Microbiology Spectrum [Category] MERS, SARS, 임상,

Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses

리포터 발현 바이러스를 이용한 생체 내 SARS-CoV-2 감염 역학 분석

423

Published on 2021-10-122022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 치료법,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin angiotensin converting enzyme antibody causative agent coronavirus COVID-19 COVID-19 pandemic CoVs cultured cell deleted deleting dissemination dynamic effective enzyme exhibited expressed expressing expression level fluorescent followed by Frame Genes hACE2 high stability identify in vitro in vivo in vivo imaging Infection K18 locus lung MONITOR neutralize noninvasive nucleocapsid Open reading frame ORF Pathogenesis pathogenicity Protein proteolytic cleavage public health replaced REPLACED BY Replication reporter reporter expression reporter gene reporter genes reporter viruses respiratory retained SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Significance the SARS-CoV-2 the viral nucleocapsid therapeutic intervention therapeutic interventions threat transgenic mice Treatment upstream Venus Viral viral infection viral replication virus viruses whole organism wild-type
[DOI] 10.1073/pnas.2111593118 PMC 바로가기 [Article Type] 423

SARS-CoV-2 Spike protein enhances ACE2 expression via facilitating Interferon effects in bronchial epithelium

SARS-CoV-2 스파이크 단백질은 기관지 상피에서 인터페론 효과를 촉진하여 ACE2 발현을 향상시킵니다.

Article

Published on 2021-09-012022-09-11
Journal: Immunology letters [Category] SARS, 치료기술,

[키워드] ACE2 ACE2 expression activate Activation Analysis Antiviral association BEAS-2B BEAS-2B cell Beas-2B cells Bronchial epithelium co-immunoprecipitation co-IP downstream Effect Effects ENhance epithelial cell epithelial cell line expression help Host identify IFN Infection Interaction interferon ISG ISG15 ISGs JAK-STAT signaling JAK1 non-structural protein non-structural proteins overexpressed overexpression Phosphorylation promote Protein qRT-PCR receptor ACE2 RNA-Seq S protein SARS-CoV-2 SARS-CoV-2 receptor SARS-CoV-2 S spike STAT Stat1 STAT2 the SARS-CoV-2 Transcriptome transcriptome analysis Type upstream was performed were measured western blot
[DOI] 10.1016/j.imlet.2021.06.008 PMC 바로가기 [Article Type] Article

COVID-19: an ‘extraterrestrial’ disease?

Mini review

Published on 2021-09-012022-10-05
Journal: International Journal of Infectious Diseases [Category] SARS, 신약개발, 조류인플루엔자,

Identification of Novel Gene Signatures using Next-Generation Sequencing Data from COVID-19 Infection Models: Focus on Neuro-COVID and Potential Therapeutics

Pharmacology

Published on 2021-08-312022-10-31
Journal: Frontiers in Pharmacology [Category] COVID-19,

[키워드] acute respiratory syndrome addition analyzed approach Bronchial epithelium camptothecin can be used cause CDS Cell cell type cerebrospinal fluid characteristic CLC Cluster common cold Coronavirus disease-19 COVID-19 COVID-19 infection CSF dendritic cell disease enrichment analysis evaluated family Coronaviridae focus Gene Expression Omnibus gene expression profile gene signature gene signatures Genes Genomics GEO GSE147507 GSEA hypertension identification illness Illumina Immune cell JQ1 knowledge mock-treated Mortality multiple organ failure neuro-COVID Neurological complication next-generation knowledge discovery platforms NHBE novel Ontology Pathologies Pathways patients platform Potential Qiagen Quality control reversed RNA sequencing RNA-seq analysis RNA-seq read SARS-CoV-2 Sickness signature single-cell small molecule Small molecules stroke therapeutic potential Therapeutics transcriptomics trichostatin A United States upstream were used
[DOI] 10.3389/fphar.2021.688227 PMC 바로가기 [Article Type] Pharmacology

Genomics-guided identification of potential modulators of SARS-CoV-2 entry proteases, TMPRSS2 and Cathepsins B/L

Research Article

Published on 2021-08-182022-10-28
Journal: PLoS ONE [Category] COVID-19, SARS,

“Waste Not, Want Not” — Leveraging Sewer Systems and Wastewater-Based Epidemiology for Drug Use Trends and Pharmaceutical Monitoring

Preliminary Research

Published on 2021-08-162022-10-30
Journal: Journal of Medical Toxicology [Category] Coronavirus, MERS, SARS,

[키워드] aggregation analogue Analysis application Biomarker change COVID-19 disease COVID-19 pandemic develop disorder downstream drug drugs Epidemic Epidemiology fentanyl include manuscript medication metabolites MONITOR monitoring opioids Pathogens pharmaceutical plant powerful tool provide public health Research sewer Sewers Stimulants Surveillance System Treatment trend upstream Want wastewater
[DOI] 10.1007/s13181-021-00853-4 PMC 바로가기 [Article Type] Preliminary Research

Rethinking COVID-19 test sensitivity-a strategy for improving the detection limit

COVID-19 테스트 감도 재검토-탐지 한계 개선을위한 전략

Perspectives

Published on 2021-08-162022-09-01
Journal: The Pan African Medical Journal [Category] MERS, 진단,

The genetic architecture of plasma kynurenine includes cardiometabolic disease mechanisms associated with the SH2B3 gene

Article

Published on 2021-08-022022-10-04
Journal: Scientific Reports [Category] 바이오마커,

[키워드] approach association Biomarker C-reactive protein cardiometabolic disease cardiovascular diseases chronic inflammation clinical phenotype conducted contributing to CRP diagnose Disease genetics examined FDR Gene regulation Genetic genetic architecture humans identify include increase increased risk independent Inflammation Inflammatory inflammatory pathway involved marker mechanism mendelian randomization metabolism metabolite mice missense variant obesity Pathways plasma Plasma level polymorphism Prognostic markers Record regulate Regulation risk Sh2b3 single-nucleotide SNP SNPs SNPs mapping upstream Variability variant
[DOI] 10.1038/s41598-021-95154-9 PMC 바로가기 [Article Type] Article

Vitamin D, infections and immunity

비타민 D, 감염 및 면역

Review

Published on 2021-07-292022-09-10
Journal: Reviews in Endocrine & Metabolic Disorders [Category] 유전자 메커니즘,

[키워드] β-defensin 2 25-hydroxyvitamin D accelerate Analysis Antibacterial antimicrobial peptide antimicrobial peptides Antiviral antiviral responses arising autophagy benefit best CAMP caries cascades Cathelicidin characterized condition COVID-19 COVID-19 crisis COVID-19 pandemic Critical CYP27B1 deficiency Dental caries disease severity Diseases downstream dysregulation epidemiological Evidence expression expression of gene greater handling Health identify Immune cell immune cells immune responses Immunity in some induce Infection Infectious diseases Inflammation Inflammatory bowel disease inflammatory bowel diseases innate immune innate immune response innate immune responses innate immune system intestinal flora intracellular pathogens knowledge Laboratory Local macrophages mechanism microbial Mortality NOD2 pathogen Pathogens Pattern recognition Pattern recognition receptors peptide peptides Poor promote provide reduce respiratory respiratory tract severity Signaling signaling cascade signaling cascades skeletal stimulate Strong susceptibility therapeutic intervention therapeutic interventions therapeutic potential Tuberculosis turn upstream Vaccines Viral viral infections Vitamin D vitamin D deficiency Vitamin D status Vitamin D supplementation
[DOI] 10.1007/s11154-021-09679-5 PMC 바로가기 [Article Type] Review