SARS-CoV-2 mRNA vaccine induced higher antibody affinity and IgG titers against variants of concern in post-partum vs non-post-partum womenSARS-CoV-2 mRNA 백신은 산후 여성과 비 산후 여성에서 우려되는 변이체에 대해 더 높은 항체 친화도 및 IgG 역가를 유도했습니다.Article Published on 2022-03-012022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 진단, [키워드] affinity Affinity maturation Amino acid amino acids antibody antibody affinity Antibody binding antibody neutralisation titres Beta both groups characterisation comparable controls countermeasure COVID-19 declined Delta described domain FDA groups help IgG titer immune response immune responses in both groups initiative knowledge Limited manuscript mRNA mRNA vaccine mutant neutralisation neutralisation titre neutralising ability plasma plasma antibody profile RBD SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants significantly higher spike supported sustained tested vaccination Vaccination strategies Vaccination strategy Vaccine vaccine-induced antibody response variants of concern VoC VOCs women [DOI] 10.1016/j.ebiom.2022.103940 PMC 바로가기 [Article Type] Article
DNA Vaccines Expressing the Envelope and Membrane Proteins Provide Partial Protection Against SARS-CoV-2 in Mice엔벨로프 및 막 단백질을 발현하는 DNA 백신은 생쥐에서 SARS-CoV-2에 대한 부분적 보호를 제공합니다Article Published on 2022-02-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Against caused cellular Cellular immune response cellular response conserved coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-protective DNA DNA vaccine dose effective Electroporation elicited envelope envelope protein Epitopes humoral Humoral immunity Humoral response immune responses immunisation International Intramuscular injection lung tissue membrane membrane protein mice pandemic Partial protection Protein provided public health emergency respiratory robust SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus Significant structural protein structural proteins T-cell epitope target titre Vaccination strategies Vaccination strategy Vaccine vaccine candidate vaccine candidates Vaccines virus [DOI] 10.3389/fimmu.2022.827605 PMC 바로가기 [Article Type] Article
Mitigating the SARS-CoV-2 Delta disease burden in Australia by non-pharmaceutical interventions and vaccinating children: a modelling analysis비 약제 개입 및 백신 접종 아동에 의한 호주에서 SARS-COV-2 델타 질병 부담 완화 : 모델링 분석Research Article Published on 2022-02-182022-09-10 Journal: BMC Medicine [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종, [키워드] activating Activation age Analysis appear assumed benefit BNT162b2 BNT162b2 Pfizer Border can not children country Coverage COVID-19 COVID-19 vaccination death Delta delta variant determine disease Effectiveness evaluate evaluated exceeded feasible Health healthcare facility hospitalisation hospitalisations Immunity include Increases Infection intensive care International Intervention measure Measures Mitigation strategy effectiveness modelling moderate Non-pharmaceutical measures NPI NPIs outbreak physical distancing predicted Prevent quantified reduce reduction in reductions reductions in Result resulting Revised 2nd January 2022 SARS-CoV-2 SARS-CoV-2 transmission shown supplementary material suppress the SARS-CoV-2 Transmission Travel vaccination Vaccination strategies Vaccination strategy Vaccine was used [DOI] 10.1186/s12916-022-02241-3 PMC 바로가기 [Article Type] Research Article
Intensity and Dynamics of Anti-SARS-CoV-2 Immune Responses after BNT162b2 mRNA Vaccination: Implications for Public Health Vaccination StrategiesArticle Published on 2022-02-172022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Affect age Antibody responses Autoimmune disease automated BNT162b2 BNT162b2 mRNA cell-mediated immune response cellular response Cellular responses correlation COVID-19 COVID-19 infection COVID-19 vaccination demonstrated dose Dynamics ELISA assays enrolled evaluated first dose first vaccination humoral Humoral response IgA IgA response IgA titer IgG IgG response IgG responses immunization implication individual information intensity Laboratory majority median Microparticle of BNT162b2 Participants positive antibody response positively correlated Public public health required response second vaccination significantly Strategy systemic adverse reaction T cell responses vaccinated individuals vaccination Vaccination strategies were assessed [DOI] 10.3390/vaccines10020316 PMC 바로가기 [Article Type] Article
Longitudinal analysis of antibody dynamics in COVID-19 convalescents reveals neutralizing responses up to 16 months after infection Research Published on 2022-02-072022-10-05 Journal: Nature Microbiology [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] Analysis Anti-RBD IgG antibody assays asymptomatic infection asymptomatic infections Beta circulating variant collected convalescent coronavirus disease COVID-19 declined decrease Delta detectable disease illness onset Immunity Infection laboratory confirmation longitudinal majority microneutralization Mild NAb Neutralization assay Neutralizing activity neutralizing antibody neutralizing response pandemic peaked persistent plasma sample pseudotyped reduced response Result reveal SARS-CoV-2 significantly symptomatic tested These data titre titres undetectable vaccination Vaccination strategies variants [DOI] 10.1038/s41564-021-01051-2 [Article Type] Research
B Cell Composition Is Altered After Kidney Transplantation and Transitional B Cells Correlate With SARS-CoV-2 Vaccination ResponseMedicine Published on 2022-02-022022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 105 patient affected Altered Analysis antibody Antigen B cell B cells Blood BNT162b2 CD27 CD5 CD86 change CKD CKD G5 collected COVID-19 COVID-19 pandemic dialysis dose double negative downregulated Efficacy explain expression flow cytometric Follow-up Frequency heterogeneous immune response implication increased mortality individuals investigated kidney kidney transplant recipient Kidney transplantation lymphocyte memory mRNA-1273 mRNA-based vaccine naïve non-responders Patient patients Peripheral blood plasmablast recruited reduced remained response Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination seroconversion rate serological response shown significantly subjects subpopulation subset transplantation vaccination Vaccination strategies venous was performed [DOI] 10.3389/fmed.2022.818882 PMC 바로가기 [Article Type] Medicine
Strategies for COVID-19 vaccination under a shortage scenario: a geo-stochastic modelling approach부족 시나리오 하에서 Covid-19 백신 접종 전략 : 지리학 적 모델링 접근법Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 치료기술, [키워드] applied approach compartment country COVID-19 COVID-19 vaccination effective Epidemiology Evolution Health Organization Horizon Immunity immunization include infections Isolation Mobility open pandemic parameter positive reduce reduced repetition shown Spain Statistical physics, thermodynamics and nonlinear dynamics Strategy vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines virus Waves World Health Organization [DOI] 10.1038/s41598-022-05481-8 PMC 바로가기 [Article Type] Article
Analysis of Delayed Vaccination Regimens: A Mathematical Modeling ApproachArticle Published on 2022-01-222022-10-31 Journal: Epidemiologia [Category] COVID-19, [키워드] Affect complex coronavirus disease country COVID-19 COVID-19 transmission deaths Delayed delayed dose develop distribution doses Efficacy example first dose Health hospitalizations identify Immunity mathematical mathematical modeling mechanism of action modeling number of infected outcome outcomes regimen SARS-CoV-2 virus second dose Simulation United Kingdom USA vaccination Vaccination strategies Vaccine Vaccines variable [DOI] 10.3390/epidemiologia2030021 PMC 바로가기 [Article Type] Article
Patterns of neutralizing humoral response to SARS-CoV-2 infection among hematologic malignancy patients reveal a robust immune response in anti-cancer therapy-naive patients혈액 학적 악성 악성 환자들 사이에서 SARS-COV-2 감염에 대한 체액 반응을 중화시키는 패턴은 항암 치료-상대 환자에서 강력한 면역 반응을 나타낸다.Clinical Trial Published on 2022-01-182022-09-01 Journal: Blood Cancer Journal [Category] 임상, 진단, [키워드] analyzed anti-cancer treatment anti-SARS-CoV-2 humoral Chemotherapy COVID-19 cross-sectional cross-sectional study enhanced geometric geometric mean Haematological cancer Hematologic malignancy HM patient HM patients humoral IgG titers immune response Infection Infectious diseases lowest lymphoid malignancy Medical research natural infection neutralization titer Neutralizing Neutralizing activity Patient pattern PCR-confirmed Post-infection question raising receive receiving robust SARS-CoV-2 immunity SARS-COV-2 infection seroconversion rate seroconvert serum severe COVID-19 symptomatic symptomatic COVID-19 the patient therapy understanding Vaccination strategies Vaccination strategy Vaccine vulnerable population [DOI] 10.1038/s41408-022-00608-6 PMC 바로가기 [Article Type] Clinical Trial
Surviving Older Patients Show Preserved Cellular and Humoral Immunological Memory Several Months After SARS-CoV-2 Infection생존한 고령 환자들은 SARS-CoV-2 감염 후 수개월 동안 세포 및 체액 면역학적 기억이 보존됨을 보여줍니다Article Published on 2022-01-072022-09-11 Journal: The Journals of Gerontology Series A: Biological S [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age analyzed anti-N antibodies anti-N antibody anti-N IgG anti-S anti-S IgG antibodies coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical determined by donors effective ELISA ELISPOT enzyme enzyme-linked immunosorbent enzyme-linked immunosorbent assay Fewer patient Fewer patients granzyme B had more heterogeneity hospital Humoral response IFN-γ IgG1 immune responses Immunity Immunological memory immunosenescence in some infected individuals Infection interferon interferon-γ life lymphocyte Lymphocytes memory memory B memory B cell memory B cells memory B lymphocytes memory T memory T lymphocytes Month Older pandemic Patient Peripheral blood positively correlated preserved producer cell quantified recovered patient reduce resolved respiratory respond response responses robust SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe symptom show Specific specific antibodies specific immunity T lymphocyte T lymphocytes understanding Vaccination strategies virus were measured [DOI] 10.1093/gerona/glab206 PMC 바로가기 [Article Type] Article