Torque teno virus DNA load as a predictive marker of antibody response to a three-dose regimen of COVID-19 mRNA-based vaccine in lung transplant recipientsArticle Published on 2022-07-012022-10-05 Journal: The Journal of heart and lung transplantation : th [Category] COVID19(2023년), SARS, 바이오마커, 변종, 진단, [키워드] 95% confidence interval Analysis Anti-RBD IgG anti-receptor-binding domain Antibody Response Antibody titer association Biomarker BNT162b2 Characteristics COVID-19 COVID-19 vaccine cut-off develop DNA dose doses evaluate Factors Future IgG response Immunosuppression investigated LTR lung transplant lung transplantation marker mRNA vaccine mRNA-1273 mRNA-based vaccine multivariate logistic regression neutralized Neutralizing antibodies non-responders Omicron variant Patient positive Predictive previous study Ratio RBD recipient reflect regimen reported respond poorly responders ROC Curve second dose Seroconversion the antibody response torque torque teno virus Treatment vaccination Vaccine vaccine response viral DNA virus [DOI] 10.1016/j.healun.2022.07.008 [Article Type] Article
Niclosamide-A promising treatment for COVID-19니클로사미드-코로나19에 대한 유망한 치료제Review Published on 2022-07-012022-09-11 Journal: British Journal of Pharmacology [Category] Coronavirus, COVID19(2023년), SARS, 신약개발, 치료제, [키워드] addition Anti-inflammatory Antibacterial anticancer antiviral activity Clinical studies clinical trial clinical trials concomitant therapies COVID-19 drug drug-resistant Effect health condition intranasal nebulized niclosamide Pandemics pleiotropic Primary infection rationale reduced repurposing robust Safe SARS-CoV-2 severity of COVID-19 shown strain susceptible individuals Therapies Transmission Treatment treatment for COVID-19 vaccine response [DOI] 10.1111/bph.15843 PMC 바로가기 [Article Type] Review
Humoral response to coronavirus disease-19 vaccines is dependent on dosage and timing of rituximab in patients with rheumatoid arthritis코로나바이러스 질병-19 백신에 대한 체액 반응은 류마티스 관절염 환자에서 리툭시맙의 투여량 및 시기에 따라 달라집니다Observational Study Published on 2022-06-282022-09-12 Journal: Rheumatology (Oxford, England) [Category] MERS, 임상, 진단, [키워드] 95% CI age biologic biologic therapies Complete Coronavirus disease-19 COVID-19 COVID-19 vaccination dependent on dosage dose humoral Humoral response investigated methotrexate multivariable logistic regression Netherland Odds ratio Patient patients patients treated positive response RA receiving rheumatoid arthritis rituximab RTX significantly total Ig vaccination Vaccine vaccine response [DOI] 10.1093/rheumatology/keac206 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 vaccine in patients with systemic sclerosis: impact of disease subtype and therapy전신 경화증 환자의 SARS-CoV-2 백신: 질병 하위 유형 및 치료의 영향Clinical Trial Published on 2022-06-282022-09-12 Journal: Rheumatology (Oxford, England) [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] affected affecting anti-SARS-CoV-2 Antibody Response baseline comparable Control controls CoronaVac disease dose Factor first dose Follow-up Frequency immunogenicity immunosuppressive inactivated individual Interstitial lung disease majority median age MMF moderate monotherapy Most patient Multiple mycophenolate neutralizing antibody Participants Patient Prospective Study regression analysis respiratory safety profile SARS-CoV-2 SARS-CoV-2 vaccine Seroconversion Side-effect subgroup of patients Systemic sclerosis therapy Trial vaccination Vaccine vaccine response were assessed [DOI] 10.1093/rheumatology/keab886 PMC 바로가기 [Article Type] Clinical Trial
Advanced Liver Fibrosis Correlates With Impaired Efficacy of Pfizer-BioNTech COVID-19 Vaccine in Medical Employees진행성 간 섬유증은 의료진에서 화이자-바이오엔텍 코로나19 백신의 효능 저하와 상관관계가 있습니다Article Published on 2022-06-012022-09-12 Journal: Hepatology communications [Category] MERS, 진단, [키워드] acute respiratory syndrome age booster calculated candidate center chronic liver disease coronavirus coronavirus disease correlated COVID-19 COVID-19 vaccine displaying Efficacy employee Factor FIB-4 fibrosis Fibrosis-4 Gender General population hepatic fibrosis IgG IgG level IgG titer Immunoglobulin Immunosuppressed Impaired Increased individual Jerusalem male males offered Older age Pfizer-BioNTech provide Responder risk factor significantly subgroups Undetermined vaccination Vaccine Vaccine failure vaccine response weakened [DOI] 10.1002/hep4.1901 PMC 바로가기 [Article Type] Article
SARS-COV-2 vaccine responses in renal patient populations신장 환자 집단에서 SARS-COV-2 백신 반응Multicenter Study Published on 2022-05-312022-09-12 Journal: BMC Nephrology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] Adenovirus adjusted odds ratio antibody Antibody Response Autoimmune Autoimmune disease AZ vaccine Breakthrough infection CKD conducted COVID-19 dialysis group healthy control healthy controls Immunosuppressed Immunosuppression increased risk kidney transplant Lower Luminex assay MMF mRNA multicentre multiplex mycophenolate occurred Oxford-AstraZeneca Patient patient population patients Pfizer Population positive response receiving recipients recruited reduced renal repeated response response to vaccination rituximab SARS-CoV-2 SARS-CoV-2 IgG antibody SARS-CoV-2 vaccine second dose Spike protein Transplant trials vaccination Vaccine vaccine doses vaccine response were excluded were measured [DOI] 10.1186/s12882-022-02792-w PMC 바로가기 [Article Type] Multicenter Study
Long-Lived Immunity in SARS-CoV-2-Recovered Children and Its Neutralizing Capacity Against OmicronSARS-CoV-2 회복 아동의 장기 면역 및 오미크론에 대한 중화 능력Article Published on 2022-05-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] activity Against antibody Antibody Response Antigen Asymptomatic Capacity CD4 T cell CD8 T cell CD8 T cells cellular immune responses children Cohort COVID-19 cross-neutralization D614G declined effectively controlled fold humoral Humoral and cellular immune responses immune immune memory immune responses Immunity IMPROVE induce Infection lack memory T cell memory T cells Mild neutralization neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody omicron pre-existing immunity pre-immune recall remained response robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-specific T cells seronegative T cell T cells vaccination Vaccine vaccine response variant variants variants of concern [DOI] 10.3389/fimmu.2022.882456 PMC 바로가기 [Article Type] Article
Association between history of HBV vaccine response and anti-SARS-CoV-2 spike antibody response to the BioNTech/Pfizer’s BNT162b2 mRNA SARS-CoV-2 vaccine among healthcare workers in Japan: A prospective observational study일본 의료 종사자들 사이에서 BioNTech/Pfizer의 BNT162b2 mRNA SARS-CoV-2 백신에 대한 HBV 백신 반응과 항 SARS-CoV-2 스파이크 항체 반응의 연관성: 전향적 관찰 연구Observational Study Published on 2022-05-162022-09-12 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] 95% confidence interval age Analysis anti-SARS-CoV-2 Antibody Response Antibody titer baseline BNT162b2 BNT162b2 mRNA BNT162b2 vaccine booster dose calculated Comorbidity comparable confidence interval COVID-19 pandemic defined dose doses faster follow-up study HBV healthcare healthcare worker immune response Inadequate long term non-responder participant Patient pharmaceutical prospective observational study protective immunity Protein recruited Responder responses against risk Roche S-protein SARS-CoV-2 SARS-CoV-2 vaccine second dose seroconvert seroconverted single dose tested university vaccination Vaccine vaccine response [DOI] 10.1371/journal.pone.0268529 PMC 바로가기 [Article Type] Observational Study
Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study)SARS-CoV-2 백신 부스터 후 2주간 저용량 메토트렉세이트 치료를 일시적으로 중단하는 것이 염증성 질환이 있는 면역억제 성인의 백신 반응에 미치는 영향: 다기관 무작위 대조 시험 및 중첩 기전 하위 연구 프로토콜(Vaccine Response On/Off Methotrexate(VROOM) ) 공부하다)Article Published on 2022-05-032022-09-11 Journal: BMJ Open [Category] COVID19(2023년), SARS, 임상, [키워드] 1:1 adjusted Analysis Anti-spike antibody approved Arm ARMS assessment Autoimmune B-cell baseline biochemical booster booster vaccination clinical trials clinics collected conducted conferences COVID-19 Dermatology disease Disease activity domain Effect ENhance Ethics ethics committee evaluate Factor feasibility group Health Research Authority immune response Immunosuppressed IMPROVE Inflammatory inflammatory conditions Intention intention to treat Intervention investigated IRAS low-dose main outcome measure memory methotrexate multicentre neutralising antibody titre Open-label Other parallel group participant Participants Patient peer review performed Pragmatic Primary outcome protocol randomisation randomised randomised controlled randomised controlled trial RBD REC registration number repeated measure repeated measures required Research Ethics response Result rheumatology Sample size SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine secondary outcome secondary outcome measure subject T-cell Response Treatment Trial UK hospitals usual care vaccination against COVID-19 vaccine response West written Informed Consent [DOI] 10.1136/bmjopen-2022-062599 PMC 바로가기 [Article Type] Article
Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab리툭시맙으로 치료받은 다발성 경화증 환자에서 SARS-CoV-2 백신 접종에 대한 혈청학적 반응과 관련된 요인Article Published on 2022-05-022022-09-12 Journal: JAMA Network Open [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] accumulated age analyzed angiotensin-converting enzyme 2 Anti-RBD IgG anti-receptor-binding domain Anti-spike anti-Spike IgG antibodies antibody B cells B-cell binding antibody CD19+ CD4+ T-cell CD8+ T-cell cellular response cohort study conducted COVID-19 infection Cutoff cutoff value Diagnosis disease dose Factor first vaccination Follow-up greater identify IgG IgG antibodies Immunoglobulin interferon gamma median monoclonal antibody Multiple multiple sclerosis Neutralizing outcome outcomes Patient patients evaluated peptide pool positive response positive test result proportion prospective cohort study quantitation RBD reached response rituximab SARS-CoV-2 sclerosis serological response spot-forming unit T-cell Response the median Treatment university hospital vaccination vaccine response Vaccines were assessed were measured women [DOI] 10.1001/jamanetworkopen.2022.11497 PMC 바로가기 [Article Type] Article