Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions벡터 - 호스트 상호 작용을 조절하기 위해 아데노 바이러스 벡터의 유전자 및 화학 캡시드 변형Review Published on 2021-07-022022-09-10 Journal: Viruses [Category] SARS, 치료법, [키워드] Adenovirus capsid capsid modification cellular Chemical chemical modification classic component COVID-19 COVID-19 pandemic COVID-19 vaccine evade Gene therapy generate Genetic HPMA humans immune system Immunity induce Interaction Modification modulate modulated PEGylation pre-existing immunity Safe Vaccine vector vectors virotherapy widespread [DOI] 10.3390/v13071300 PMC 바로가기 [Article Type] Review
Detecting Emotional Evolution on Twitter during the COVID-19 Pandemic Using Text Analysis텍스트 분석을 사용하여 COVID-19 팬데믹 동안 트위터에서 감정적 진화 감지하기Article Published on 2021-06-292022-09-10 Journal: International Journal of Environmental Research an [Category] MERS, SARS, 치료기술, [키워드] activities affected capture carried coronavirus country COVID-19 disease dynamic sentiment Evolution expressed Health Organization high mortality rate individual information New coronavirus occurred opinion outbreak outcome pandemic pandemic evolution problem reaction related disease SARS-CoV-2 selected sentiment analysis situation social networks Spain Spanish text transmission rate triggered Twitter Variation vector vectors virus WHO World Health Organization World War World War II Wuhan Wuhan, China [DOI] 10.3390/ijerph18136981 PMC 바로가기 [Article Type] Article
In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus originSARS-COV-2 스파이크 단백질 -ACE2 결합 친화력의 SILICO 비교에서 종에 대한 바이러스 기원에 대한 영향Article Published on 2021-06-242022-09-10 Journal: Scientific Reports [Category] MERS, 유전자 메커니즘, [키워드] ACE2 affinity analyses angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 approach binding binding affinity can be used caused Chemistry Computational biology and bioinformatics Computational chemistry correlation COVID-19 pandemic Diseases docking Drug discovery enzyme exhibited explain ferret generate hACE2 help helping highest highest binding affinity highlight human ACE2 humans hydrogen Hydrogen bond hydrogen bonds implication in silico Infection information mechanism molecular dynamics Molecular dynamics simulation much lower novel virus Novel viruses pangolin power predict predicted Protein question raised respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 isolate SARS-CoV-2 spike sequence sequence homology sequence similarity shown Small molecules spike Spike protein structural biology structural homology susceptibility tested transfer Transmission vectors virus viruses [DOI] 10.1038/s41598-021-92388-5 PMC 바로가기 [Article Type] Article
A Summary of the SARS-CoV-2 Vaccines and Technologies Available or under DevelopmentReview Published on 2021-06-222022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] age clinical trial clinical trials country COVID-19 COVID-19 pandemic develop development DNA vaccines dosage Effect effective Factor humans immune response inactivated viruses include initiated Live attenuated vaccines Messenger RNA Modification mounted mRNA mutated variant mutated variants outcomes parameters Phase 3 Protein protocol researcher SARS-CoV-2 Seven Side effects storage conditions subunits technology the SARS-CoV-2 Vaccine vaccinee Vaccines vectors viral-like particles [DOI] 10.3390/pathogens10070788 PMC 바로가기 [Article Type] Review
The current landscape of nucleic acid therapeutics Reviews Published on 2021-05-312022-10-05 Journal: Nature nanotechnology [Category] 변종, 유전자 메커니즘, [키워드] addition adeno-associated virus Antisense oligonucleotides approaches approved causes clinically Conjugates Conventional curative disease drugs Effect example explain facilitate facilitated Genetic highlight IMPROVE in vivo induce Lipid nanoparticle long-lasting Messenger RNA nucleic acid platform RNA stability target protein therapeutic effect translation treat Treatment vectors [DOI] 10.1038/s41565-021-00898-0 [Article Type] Reviews
Vectored Immunotherapeutics for Infectious Diseases: Can rAAVs Be The Game Changers for Fighting Transmissible Pathogens?Immunology Published on 2021-05-112022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] adeno-associated virus antibody antigens Can Clinical efficacy Clinical studies Conventional de novo synthesis Diseases Efficacy Efficiency expression Fighting foreign protein game Gene therapy genomic variation HIV Host Immunity immunomodulatory immunotherapies Immunotherapy in vivo Infection Infectious disease Influenza inherent lentivirus malaria mechanism neutralizing antibody offer passive transfer Pathogens pre-existing immunity profiles Prophylactic reduce repeated Severity of disease single dose tested therapeutic strategy Topology transgene Treatment vaccination Vaccines vectors viral vectors virus [DOI] 10.3389/fimmu.2021.673699 PMC 바로가기 [Article Type] Immunology
Medical Specialty Recommendations by an Artificial Intelligence Chatbot on a Smartphone: Development and DeploymentOriginal Paper Published on 2021-05-062022-10-30 Journal: Journal of Medical Internet Research [Category] Coronavirus, SARS, [키워드] activity adopted artificial artificial intelligence AUC bidirectional can be used characteristic chatbot collected conducted Contact COVID-19 COVID-19 pandemic deep learning Deployment develop development evaluated identify include information intelligence limitation machine learning medical specialty memory more difficult natural language processing objective offer Patient Precision primary care Randomly recall recommendation resource Result selected Smartphone Symptom Symptoms transformer vector vectors [DOI] 10.2196/27460 PMC 바로가기 [Article Type] Original Paper
Probiotic-Based Vaccines May Provide Effective Protection against COVID-19 Acute Respiratory DiseaseReview Published on 2021-05-062022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome addition adjuvants Administered administration approach Cell-mediated immune responses clinical information codon usage concern coronavirus COVID-19 cross-talk dose Effectiveness elicit Emergency expression level highlight IgA antibody immune response immune responses immune system induce Infection infections microorganism microorganisms modulating modulation mucosal mucosal immune Mucosal immunization mucosal route nasal neutralize previous study Probiotics Prospective Study protection Protective Public respiratory responses SARS-CoV-2 SARS-COV-2 infection serum IgG shown Therapeutic molecule therapeutic molecules therapy transmitted Vaccine development Vaccines vectors virus viruses WHO World Health Organization [DOI] 10.3390/vaccines9050466 PMC 바로가기 [Article Type] Review
Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessmentReview article Published on 2021-05-012022-10-05 Journal: Vaccine [Category] SARS, 비임상, [키워드] Ad26 adenoviral vector Adenovirus baseline Benefit/Risk cellular immune responses Characteristics clinical clinical evaluation clinical study clinical trials collaboration COVID-19 vaccine database Ebola virus effective evaluate evaluated Express expression Extensive feature FIVE flexible Genetic group Human humoral key consideration mammalian cell Neutralizing antibody titer New participant Phase 3 platform pre-existing immunity profiles regimen Replication Replication-incompetent Ad26 risk Safety T cell response transgene Trial Vaccine Vaccine development vaccine immunogenicity Vaccines variety vector vectors Viral vector Viral vector vaccines working [DOI] 10.1016/j.vaccine.2020.09.018 [Article Type] Review article
Safe and effective two-in-one replicon-and-VLP minispike vaccine for COVID-19: Protection of mice after a single immunizationCOVID-19에 대한 안전하고 효과적인 2-in-1 레플리콘 및 VLP 미니스파이크 백신: 단일 면역 후 마우스 보호Research Article Published on 2021-04-212022-09-12 Journal: PLoS Pathogens [Category] MERS, SARS, 진단, [키워드] animals Antigen antigen expression approach Author boost build candidate caused Cell cell surface chimeric classic Complication concern COVID-19 disease COVID-19 patients COVID-19 vaccine Critical disease domain effective Efficiency emergence of virus encoding enhancement envelope expressing expression functional glycoprotein humans immune response immunization immunogen include induce K18-hACE2 mice mice Neutralizing activity Neutralizing antibodies non-infectious Non-neutralizing antibodies outcome Particles pathogenic problem protection protective immune response Protein Rabies virus RBD RBD antigen Receptor binding domain Replication replication-competent virus replication-competent viruses RNA S antigen Safe SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 pandemic SARS-CoV-2 spike secreted sequence Side effect single dose Spread stimulated transgenic transmembrane tropism of SARS-CoV-2 vaccination Vaccine vaccine platform vectors vesicular stomatitis vesicular stomatitis virus viral DNA virus virus propagation Virus-like particle virus-neutralizing antibody VLP VLPs VSV VSVΔG [DOI] 10.1371/journal.ppat.1009064 PMC 바로가기 [Article Type] Research Article