Severe Acute Respiratory Syndrome Coronavirus 2 Viremia Is Associated With Coronavirus Disease 2019 Severity and Predicts Clinical Outcomes중증 급성 호흡기 증후군 코로나바이러스 2 바이러스혈증은 코로나바이러스 질병 2019 심각도와 연관되어 있으며 임상 결과를 예측합니다Observational Study Published on 2022-05-032022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), MERS, SARS, 바이오마커, 임상, 진단, 치료기술, [키워드] 19 outcome 2 RNAemia 2 viremia acute respiratory syndrome acute respiratory syndrome coronavirus Admission Antibody titers bloodstream Care clinical clinical outcomes Cohort coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 COVID-19 patient COVID-19 severity cross-sectional discharge disease severity electron tomography hazard ratio Health Organization Hospitalized Host immune response host immune responses ICU ICU Patients immune responses immunostaining indicate Inflammatory biomarker Inpatients Level Mortality Neutralizing antibody titer neutralizing antibody titers non-ICU outcome outcomes Outpatient outpatients Patient pellet plasma plasma sample plasma samples quantified reflect respiratory SARS SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significantly significantly higher Viral Viral RNA Viremia virion virions virus particle virus particles Visualization vRNA WHO World Health Organization [DOI] 10.1093/cid/ciab686 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells1차 인간 기도 상피 세포에서 SARS-CoV-2 비리온 감염성과 사이토카인 생산Article Published on 2022-05-022022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Alpha B.1.1.529 B.1.1.7 B.1.351 B.1.617.2 BavPat1 Behavior Beta Cell cultures cytokine D614G mutation epithelial epithelial cell epithelial cells Evidence Ex vivo hAEC Human human airway human airway epithelial infect Infectivity Innate immunity isolate lack Lineage lineages new SARS-CoV-2 no difference observé Omicron variant Omicron variants organotypic model Physiology primary human airway Primary human airway epithelial cells Production provide replacement replicate respiratory tissue respiratory tissues SARS-CoV-2 SARS-CoV-2 variants variant variants variants of concern virion virus vRNA [DOI] 10.3390/v14050951 PMC 바로가기 [Article Type] Article
An overview on inactivated and live-attenuated SARS-CoV-2 vaccines불활성화 및 약독화 SARS-CoV-2 백신에 대한 개요Review Published on 2022-05-012022-09-11 Journal: Journal of Clinical Laboratory Analysis [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse effects antigenic attenuated vaccine benefit Bharat Cell culture Cellular immune response China clinical trials component components coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine deaths effective Efficiency Features followed by Health Organization humoral Humoral and cellular immune responses immune responses inactivated Inactivated vaccine Infection landscape Phase 3 produced producing Record report review Safe SARS-CoV-2 SARS-CoV-2 vaccine severe acute respiratory syndrome Coronavirus similarity Sinopharm Sinovac storage the vaccine Transport trials Vaccine vaccine candidate vaccine platform Vaccines virion virus particle WHO World Health Organization worldwide pandemic Wuhan [DOI] 10.1002/jcla.24418 PMC 바로가기 [Article Type] Review
Shell Disorder Models Detect That Omicron Has Harder Shells with Attenuation but Is Not a Descendant of the Wuhan-Hu-1 SARS-CoV-2껍질 장애 모델은 오미크론이 감쇠가 있는 더 단단한 껍질을 가지고 있지만 우한-Hu-1 SARS-CoV-2의 후손이 아님을 감지합니다Article Published on 2022-04-252022-09-11 Journal: Biomolecules [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] acute respiratory syndrome Analysis ancestor antimicrobial enzymes attenuation bronchus conserved contagiousness coronavirus CoV COVID-19 CoVs disorder hardness Human Infection intrinsic Intrinsic disorder lowest lung lung; Lungs membrane Model Mucus nucleocapsid nucleoprotein omicron other variant other variants pangolin pangolin-CoV pangolins Particle Phylogenetic precursor PROTECT responsible reveal Saliva SARS-CoV-2 Severe acute respiratory syndrome shell Spread suggested Support the SARS-CoV-2 Transmission variant virion virulence Wuhan-Hu-1 [DOI] 10.3390/biom12050631 PMC 바로가기 [Article Type] Article
The effect of immunization with inactivated SARS-CoV-2 vaccine (CoronaVac) and/or SARS-CoV-2 infection on antibody levels, plasmablasts, long-lived-plasma-cells, and IFN-γ release by natural killer cells비활성화된 SARS-CoV-2 백신(CoronaVac) 및/또는 SARS-CoV-2 감염이 항체 수준, 형질모세포, 수명이 긴 형질 세포 및 자연 살해 세포에 의한 IFN-γ 방출에 미치는 영향Article Published on 2022-04-202022-09-11 Journal: Vaccine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] anti-S anti-SARS-CoV-2 spike protein anti-spike antibody antibody Antibody Response B cell CD138 CD19 CD27 Cell CoronaVac COVID-19 detectable dose Elecsy elicited ELISA kit evaluated flow cytometry four groups Germinal center group groups HCW HCWs healthcare worker Healthcare workers IAV IFN-gamma IFN-γ immunization inactivated Inactivated vaccine interferon gamma İstanbul Killer cell long-lived plasma cell long-lived plasma cells Lymph node lymph nodes median memory B cell memory B cells Migration natural infection natural killer natural killer cell no difference not differ patients percentage phenotype Plasma cells plasmablast plasmablasts qPCR RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine significantly higher significantly lower Spike protein study groups Test the antibody response the study group Turkey uninfected Vaccine Version virion was performed were measured Whole virion inactivated vaccine. [DOI] 10.1016/j.vaccine.2022.03.001 PMC 바로가기 [Article Type] Article
Glycolytic inhibitor 2-deoxy-d-glucose attenuates SARS-CoV-2 multiplication in host cells and weakens the infective potential of progeny virions해당 억제제 2-deoxy-d-glucose는 숙주 세포에서 SARS-CoV-2 증식을 약화시키고 자손 비리온의 감염 가능성을 약화시킵니다Article Published on 2022-04-152022-09-11 Journal: Life sciences [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] 2-deoxy-D-glucose 2-DG Analysis attenuate Cell COVID-19 COVID-19 patients CPE Cytopathic effect Effect evaluated examined fluorescent Glucose Glycolysis glycosylation Herpe herpes host cell host cells Infection infective inhibited inhibitor investigated mass spectrometry metabolism nucleocapsid patients phenotype produced progeny virion progeny virions Protein protein expression RBD RdRP RdRp genes Receptor binding domain Receptor-binding domain reduced required resulting RT-PCR SARS-CoV-2 SARS-CoV-2 infected cells SARS-COV-2 infection SARS-CoV-2 spike protein spike Spike protein the receptor-binding domain the spike protein treated Trial Unglycosylation. Vero E6 VERO E6 cells virion virus multiplication was performed [DOI] 10.1016/j.lfs.2022.120411 PMC 바로가기 [Article Type] Article
In Vitro SARS-CoV-2 Infection of Microvascular Endothelial Cells: Effect on Pro-Inflammatory Cytokine and Chemokine Release미세혈관 내피 세포의 시험관 내 SARS-CoV-2 감염: 염증성 사이토카인 및 케모카인 방출에 대한 영향Article Published on 2022-04-062022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 receptor Activation Analysis chemokine contribute coronavirus disease Coronavirus disease 2019 cytokine release Cytokines cytoplasm days post-infection dysfunction Effect electron ELISA endothelial Endothelial cell evaluated expressed expression Human Human Microvascular Endothelial Cells (HMEC-1) IFN-α IL-6 IL-6 level IL-6 levels IL-8 in vitro Inflammatory mediators mRNA mRNA expression pandemic pro-inflammatory cytokine pro-inflammatory cytokines pro-inflammatory mediators Release RT-PCR SARS-CoV-2 SARS-COV-2 infection significantly higher significantly lower supernatant supernatants susceptible TEM These data thrombotic Thrombotic events tissue Tissue Factor TNF-α transmission electron microscopy uninfected viral amplification Viral load virion virions western blot Western blot analysis [DOI] 10.3390/ijms23074063 PMC 바로가기 [Article Type] Article
Basic virology of SARS-CoV 2SARS-CoV 2의 기본 바이러스학Review Published on 2022-04-012022-09-11 Journal: Indian journal of medical microbiology [Category] Coronavirus, COVID19(2023년), SARS, 치료법, [키워드] 229E acute respiratory disease acute respiratory syndrome acute respiratory syndrome coronavirus basic bats bind cats Cell cell surface cellular membrane Characteristics clinical manifestation coronavirus coronavirus disease Coronavirus disease 2019 COVID COVID 19 COVID-19 disease envelope Exocytosis followed by fusion Genome genomic genomic RNA global public health helical symmetry HKU1 host cell host cell cytosol hosts human coronaviruses humans Immunological response Infection mammalian membrane MERS MERS-CoV Mild NL63 nucleocapsid OC43 pandemic Pathogenesis pathogenic pathogenic coronavirus positive Protein receptor Receptor binding released RNA genome RNA synthesis S protein SARS CoV SARS CoV-2 SARS-CoV 2 SARS-CoV-2 Seven severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spread structural proteins the S protein translation transported Vesicle vesicles viral genome viral genomic RNA viral replication virion virions Virology virus [DOI] 10.1016/j.ijmmb.2022.02.005 PMC 바로가기 [Article Type] Review
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus viruses [DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article
Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine경구 랍도바이러스 백신을 사용한 비인간 영장류의 SARS-CoV-2 면역 강화Article Published on 2022-04-012022-09-12 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] administration cell tropism clinical clinical trials cynomolgus macaques effort G protein help immune response Immunity intramuscular Lipid nanoparticle Neutralizing antibodies oral Oral vaccine parental poorly immunogenic Rhabdovirus SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike glycoprotein stomatitis T cells vaccinated individual Vaccine virion virus VSV VSV. [DOI] 10.1016/j.vaccine.2021.12.063 PMC 바로가기 [Article Type] Article