Virological – Page 5 – Communicable Diseases Research

A combination of two human neutralizing antibodies prevents SARS-CoV-2 infection in cynomolgus macaques

두 개의 인간 중화 항체의 조합은 사이노몰구스 원숭이에서 SARS-CoV-2 감염을 예방합니다

Article

Published on 2022-03-112022-09-11
Journal: Med (New York, N.Y.) [Category] COVID19(2023년), MERS, SARS, 변종, 비임상, 진단,

Fatal Neurodissemination and SARS-CoV-2 Tropism in K18-hACE2 Mice Is Only Partially Dependent on hACE2 Expression

K18-hACE2 마우스의 치명적인 신경 보급 및 SARS-CoV-2 향성은 hACE2 발현에 부분적으로만 의존합니다

Article

Published on 2022-03-052022-09-11
Journal: Viruses [Category] SARS, 치료기술,

[키워드] ACE2 ACE2 protein ACE2-expressing cell ACE2-expressing cells Analysis angiotensin animal animal models AT1 axonal transport blood-brain barrier Brain bronchiolar Cell Cohort comparative pathology COVID-19 Critical cytokeratin cytokeratin 18 promoter days post-infection death Dependent detectable dose ENhance epidemiological data euthanasia evaluated Evidence expressing expression hACE2 Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hypothermia immunohistochemistry In situ hybridization in vivo in vivo imaging independent independent of inoculated intranasal K18-hACE2 Lineage Mild-to-moderate neuroepithelium Neuron neurons occur olfactory olfactory bulb olfactory neuroepithelium overexpression pathologic PFUs Pneumocytes Pneumonia portal question resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis spatiotemporal subsequent transgenic mice translational translational animal model Transmission transmission electron microscopy Transport tropism vasculature viral pathogenesis Viremia Virological
[DOI] 10.3390/v14030535 PMC 바로가기 [Article Type] Article

Multiorgan and Vascular Tropism of SARS-CoV-2

SARS-CoV-2의 다기관 및 혈관 친화성

Case Reports

Published on 2022-03-032022-09-11
Journal: Viruses [Category] SARS, 치료기술, 치료제,

[키워드] active viral replication adrenal gland Affect biopsies contribute COVID-19 COVID-19 patient deep sequencing distribution favor Genetic heterogeneous highlight histological Infection Inferior vena cava Intra-host variability investigated lower respiratory system multiple tissues Mutation organ organs other tissue other tissues pancreas Post-mortem Quasispecies respiratory tract RNA transcript SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation SARS-CoV-2 mutations Sequencing specimen Spike protein stomach the SARS-CoV-2 the spike protein tissue tissues tropism ultra-deep sequencing Variability vena Viral quasispecies Virological was performed
[DOI] 10.3390/v14030515 PMC 바로가기 [Article Type] Case Reports

First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales

Research Article

Published on 2022-02-222022-10-29
Journal: PLoS Medicine [Category] COVID-19, COVID19(2023년), MERS, SARS,

[키워드] 95% CI 95% confidence interval addition administration Analysis association assumption average baseline benefit Blood BNT162b2 Brain carried Case report case sery caused ChAdOx1 clinically Cohort combined cohort conditions Control count country COVID-19 COVID-19 vaccination dataset datasets dose doses elevated England estimates event events Evidence examined expected extreme first dose Follow-up group Health Health authority incidence rate increased risk independent indication individual information initial limitations Mortality National observation observation period of BNT162b2 Older age outcome outcome measure person year person years Pfizer-BioNTech platform Poisson model primary care Public quantification recorded required researcher risk secondary care Serious Adverse Event Study design thrombosis Topic United Kingdom vaccination Vaccine variable venous Virological with COVID-19
[DOI] 10.1371/journal.pmed.1003927 PMC 바로가기 [Article Type] Research Article

Emergence in southern France of a new SARS-CoV-2 variant harbouring both N501Y and E484K substitutions in the spike protein

스파이크 단백질에서 N501Y 및 E484K 치환을 모두 담은 새로운 SARS-COV-2 변형의 프랑스 남부의 출현

Annotated Sequence Record

Published on 2022-02-182022-09-10
Journal: Archives of Virology [Category] COVID19(2023년), Fulltext, MERS, SARS, 변종,

[키워드] Amino acid amino acid substitution amino acid substitutions Atypical Combination Deletion deletions E484K emergence epidemiological escape example France genome sequence Genome sequences Genotype geographical area index case isolate Lineage lineages Mutation N501Y new SARS-CoV-2 Next-generation sequencing nine nucleotide nucleotide substitution Oxford Nanopore Technologies Oxford Nanopore Technology pangolin Pangolin lineage Phylogenetic qPCR test resulting risk SARS-CoV-2 variant SARS-CoV-2 variants SARS-CoV-2-positive patient Spike protein Substitution supplementary material the spike protein These data Travel Vaccine-induced immunity variant Virological
[DOI] 10.1007/s00705-022-05385-y PMC 바로가기 [Article Type] Annotated Sequence Record

Modelling airborne transmission of SARS-CoV-2 using CARA: risk assessment for enclosed spaces

Articles

Published on 2022-02-112022-10-29
Journal: Interface Focus [Category] COVID-19,

Impact on HIV-1 RNA Levels and Antibody Responses Following SARS-CoV-2 Vaccination in HIV-Infected Individuals

HIV에 감염된 개인에서 SARS-CoV-2 백신 접종 후 HIV-1 RNA 수준 및 항체 반응에 대한 영향

Immunology

Published on 2022-02-102022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법,

[키워드] a minor acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adverse effect All participant All participants Anti-RBD antibodies Anti-RBD antibody Anti-S1 antibody baseline baseline CD4 binding domain BNT162b2 CD4 T-cell collected coronavirus detectable dose elicited first dose HIV HIV-1 Immunological response Impact individual individuals Level male median median age minor mRNA vaccine mRNA vaccines mRNA1273 no statistical difference observational study offered Patient patients PLWH positive RBD reported respiratory response RNA SARS-CoV-2 second dose serology severe acute respiratory syndrome Coronavirus single-center T-cells vaccination Virological were measured with HIV
[DOI] 10.3389/fimmu.2021.820126 PMC 바로가기 [Article Type] Immunology

Immunogenicity and safety of the BNT162b2 COVID‐19 mRNA vaccine in PLWH: A monocentric study in Bari, Italy

Research Article

Published on 2022-02-082022-10-04
Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] administration anti‐S1RBD antibody Antiretroviral therapy ART baseline BNT162b2 BNT162b2 mRNA vaccine BNT162b2 vaccine Characteristics Chemotherapy Comorbidities Comorbidity condition COVID‐19 COVID‐19 demonstrated diagnosed dose evaluate evaluated first dose HIV infection immunogenic immunogenicity immunological Immunosuppressed immunosuppressive Infection Italy mRNA vaccine Patient patients people with HIV PLWH positive Quantitative receiving regimen reported Risk category SAE SAEs Safe Safety SARS‐CoV‐2 SARS‐CoV‐2 serological result severe adverse event severe adverse events study population table tested time undetectable vaccination vaccine administration Virological was collected with HIV
[DOI] 10.1002/jmv.27629 PMC 바로가기 [Article Type] Research Article

A new SARS-CoV-2 variant with high lethality poorly detected by RT-PCR on nasopharyngeal samples: an observational study

비인두 샘플에 대한 RT-PCR로 잘 검출되지 않는 높은 치사율을 지닌 새로운 SARS-CoV-2 변종: 관찰 연구

Observational Study

Published on 2022-02-012022-09-11
Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술,

[키워드] 28-day mortality 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed anti-SARS-CoV-2 Characteristics chest CT scan clinical collected coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections Coronavirus infections/epidemiology Coronavirus infections/virology COVID-19 COVID-19 case COVID-19 cases Cox model enrolled feature hospital Inclusion inclusion criteria Inpatient interquartile range involved IQR Lineage Lower respiratory tract lower respiratory tract samples multivariable nasopharyngeal nasopharyngeal sample Nasopharyngeal samples new SARS-CoV-2 nosocomial Older outbreak outcome Patient positive radiological respiratory sample RT-PCR RT-PCR test RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variants Sequencing Seroconversion severe disease severity of illness severity of illness index Symptom the WHO variant Virological Virology VoC WGS whole-genome sequencing
[DOI] 10.1016/j.cmi.2021.09.035 PMC 바로가기 [Article Type] Observational Study

Longitudinal, virological, and serological assessment of hospitalized COVID-19 patients

입원한 COVID-19 환자의 종단, 바이러스 및 혈청학적 평가

Article

Published on 2022-02-012022-09-11
Journal: Journal of Neurovirology [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술,

[키워드] Admission anal swabs anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 IgM Antibody titers Blood blood sample Blood samples Cohort collected COVID-19 pandemic COVID-19 patient COVID-19 patients described discharge ELISA evaluated Evidence First wave healthcare Hospital admission Hospitalized hospitalized COVID-19 patient IgG antibody titer IgG antibody titers IgG levels IgM and IgG implication Italy longitudinal median time nasopharyngeal nasopharyngeal swabs Negative conversion NPs Patient patients positive provide qRT-PCR RNA SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 RNA detection serological assessment seropositive serum sample serum samples significantly Swab tested the median Virological
[DOI] 10.1007/s13365-021-01029-0 PMC 바로가기 [Article Type] Article