The rationale of ethanol inhalation for disinfection of the respiratory tract in SARS-CoV-2-positive asymptomatic subjectsSARS-COV-2- 양성 무증상 피험자에서 호흡기 소독을위한 에탄올 흡입의 이론적 근거Perspectives Published on 2021-12-042022-09-10 Journal: The Pan African Medical Journal [Category] MERS, SARS, 변종, [키워드] acute respiratory syndrome coronavirus affecting antibody approach asymptomatic subject benefit carried carrier clinical trial contagious diseases coronavirus coronavirus 2 COVID-19 determine dimension drug Effect Efficiency Ethanol EtOH for disinfection Health health benefits Hypothesis identify individual inhalation Inhaled knowledge limit Local monoclonal antibodies nonspecific pandemic paper PAS positive problem public health rationale respiratory respiratory tract SARS-CoV-2 SARS-CoV-2 entry Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 Support surgical the healthy therapeutic therapeutic window Toxicity treat Treatment virucidal virus variant virus variants [DOI] 10.11604/pamj.2021.40.201.31211 PMC 바로가기 [Article Type] Perspectives
Transparent Polymeric Formulations Effective against SARS-CoV-2 InfectionSARS-CoV-2 감염에 효과적인 투명한 고분자 제제Article Published on 2021-11-242022-09-11 Journal: ACS applied materials & interfaces [Category] SARS, 치료제, [키워드] 229E alternative Antibacterial antibacterial activity antimicrobial agent antimicrobial agents Antiviral antiviral activity antiviral property approaches backbone Bacteria benzalkonium Candida albican Candida albicans candidate Cell CFU class Compound compounds Contact contaminated surface contaminated surfaces coronavirus decrease droplet droplets EMA European Medicines Agency evaluated Formulation fungal gram Gram-negative bacteria Gram-positive bacteria growth increasingly inhibit Ion Particle Polymer polymers polystyrene sulfonate Postinfection product reduction SARS-CoV-2 SARS-CoV-2 coronavirus SARS-COV-2 infection SARS-CoV-2 virus silver Spread sulfonate target cell tested the SARS-CoV-2 virus Transmission transmitted variety virucidal virus [DOI] 10.1021/acsami.1c10404 PMC 바로가기 [Article Type] Article
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] COVID-19, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic CoronavirusesAntiviral Agents Published on 2021-11-222022-10-27 Journal: Antimicrobial Agents and Chemotherapy [Category] Coronavirus, COVID-19, COVID19(2023년), Fulltext, MERS, SARS, [키워드] active against activity acute respiratory syndrome Antiviral antiviral activity Antiviral agents broad-spectrum antiviral bronchial epithelial cells coronavirus CoV-229E COVID-19 CoVs demonstrated described highly active Including inhibit inhibitor mechanism of action MERS-CoV Microscopy Middle East natural natural antiviral natural product outbreak product reduced Replication respiratory syndrome coronavirus SARS-CoV-2 shown therapy viral membrane viral particle virucidal virus virus entry [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
A Photoactivable Natural Product with Broad Antiviral Activity against Enveloped Viruses, Including Highly Pathogenic Coronaviruses고도로 병원성 코로나 바이러스를 포함하여 포집 바이러스에 대한 광범위한 항 바이러스 활성을 갖는 광 활성화 가능한 천연 제품Antiviral Agents Published on 2021-11-222022-09-10 Journal: Antimicrobial Agents and Chemotherapy [Category] 치료제, [키워드] active against activity acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral activity Antiviral agents broad-spectrum antiviral broad-spectrum antivirals bronchial epithelial cells Cell fusion coronavirus CoV replication CoV-229E COVID-19 COVID-19 therapy CoVs Cryoelectron microscopy demonstrated described Disinfection epithelial cells highly active human CoV Including inhibit inhibitor mechanism of action MERS MERS-CoV Microscopy Middle East Middle East respiratory syndrome Middle East respiratory syndrome Coronavirus natural natural antiviral natural product outbreak primary human bronchial epithelial cells product reduced Replication respiratory respiratory syndrome coronavirus SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown therapy Viral viral membrane viral particle virucidal virus virus entry viruses [DOI] 10.1128/AAC.01581-21 PMC 바로가기 [Article Type] Antiviral Agents
Nanodispersions of Polyelectrolytes Based on Humic Substances: Isolation, Physico-Chemical Characterization and Evaluation of Biological ActivityArticle Published on 2021-11-182022-10-28 Journal: Pharmaceutics [Category] COVID-19, [키워드] activity antiviral activity approach binding Bioactivity Biological Cell Characteristics characterization complex complexes concentrations contribute coronavirus demonstrated detect Dilution dried droplet method effective EHA element fluorescent Frame heterogeneity humic and fulvic acids include increase in increasingly initial introduced Isolation lack medium molecular nanodispersion natural optical organ Particle particle size measurement Particles physico-chemical property polydispersity antiviral activity Polyelectrolyte polyelectrolytes Prevent Quality control Radiation receptor regulated Regulatory SEM shown spike glycoprotein stability Standardization submicron Taking the SARS-CoV-2 virus Vero E6 VERO-E6 virucidal virus X-ray zeta potential [DOI] 10.3390/pharmaceutics13111954 PMC 바로가기 [Article Type] Article
Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral MechanismsCurcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다Article Published on 2021-11-162022-09-10 Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제, [키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used [DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article
Antioxidant Activity of Citrus Limonoids and Investigation of Their Virucidal Potential against SARS-CoV-2 in Cellular ModelsArticle Published on 2021-11-102022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] acting activity antioxidant antioxidant activity approach assays Citrus components Compound COVID-19 COVID-19 pandemic effective drugs grapefruit seeds GSE investigation Isolation lack Limonoid Limonoids mechanism Model oxidative stress Potential public health purification risk SARS-CoV-2 SARS-CoV2 Severe COVID-19 Infection shown vaccination variants virucidal [DOI] 10.3390/antiox10111794 PMC 바로가기 [Article Type] Article
Curing Cats with Feline Infectious Peritonitis with an Oral Multi-Component Drug Containing GS-441524Article Published on 2021-11-052022-10-28 Journal: Viruses [Category] COVID-19, MERS, [키워드] adverse effects antibodies antiviral chemotherapy caused Cell culture Containing coronavirus curing disease drug effective Efficacy evaluate FCoV Feline coronavirus Feline infectious peritonitis FIP GS-441524 in vitro laboratory parameter Laboratory parameters linear mixed-effect models mass spectrometry Mutian nuclear oral parameter peritonitis reduction in survival rate therapy Toxicity treated Treatment treatment initiation value Viral load viral loads virucidal Xraphconn® [DOI] 10.3390/v13112228 PMC 바로가기 [Article Type] Article
The Infectious Bronchitis Coronavirus Pneumonia Model Presenting a Novel Insight for the SARS-CoV-2 Dissemination RouteArticle Published on 2021-10-182022-10-28 Journal: Veterinary Sciences [Category] COVID-19, [키워드] antigens artificial ribonuclease bronchitis caused characterized chickens contagious control group Coronaviridae coronavirus disease dose drug Effectiveness experimental group Gamma genomic hematogenous humans Hypothesis IBV inflammatory change inflammatory reaction inoculated insight intestine intestines less lung lung damage Lungs mechanism Model monoglyceride lauryl acid novel other coronavirus pathology predominant probe proportion reproductive organ Respiratory system route SARS-CoV-2 Silver nanoparticles similarity subsequent suggested the SARS-CoV-2 vaccine strain viral particle virucidal virucidal drugs virus virus RNA was tested [DOI] 10.3390/vetsci8100239 PMC 바로가기 [Article Type] Article