Communicable Disease – Page 50 – Communicable Diseases Research

Somatic Genetics Empowers the Mouse for Modeling and Interrogating Developmental and Disease Processes

Somatic Genetics는 발달 및 질병 과정을 모델링하고 조사하기 위해 마우스를 강화합니다

Review

Published on 2011-07-212022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

Interferon Regulatory Factor 8 Regulates Pathways for Antigen Presentation in Myeloid Cells and during Tuberculosis

인터페론 조절 인자 8은 골수 세포 및 결핵 기간 동안 항원 제시 경로를 조절합니다

Research Article

Published on 2011-06-232022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] (major histocompatibility complex activate Activation allele Analysis Antigen presentation antigen processing Author binding binding site cellular pathway cellular pathways chromatin chromatin immunoprecipitation class Combination component Critical cytokine Defense dendritic cell dendritic cells differentiation early response endomembrane eQTLs expressed expression F2 Factor fixed functional Gene gene transcription GTPase GTPases histocompatibility complex Host–pathogen interaction identify IFNγ IL-12 IL12 immune response Infected Infection interferon gamma interferon regulatory factor interleukin intracellular pathogens intrinsic investigated IRF8 lipopolysaccharide LPS lung tissue lung tissues Lungs Macrophage macrophages major histocompatibility complex maturation member MHC mice Microarray Microarrays microbial motif mutant Mycobacterium tuberculosis myeloid myeloid cell myeloid cells ontogeny Pathogens pathway Pathways presentation priming progenitor cells promoter promoters Proteins pulmonary tuberculosis regulated Regulation represse required resistance to infection resistance to infections significantly Stimulation susceptible target transcript Transcription transcriptional treated Tuberculosis wild-type
[DOI] 10.1371/journal.pgen.1002097 PMC 바로가기 [Article Type] Research Article

Association of Genetic Variants in Complement Factor H and Factor H-Related Genes with Systemic Lupus Erythematosus Susceptibility

보체 인자 H 및 인자 H 관련 유전자의 유전적 변이체와 전신성 홍반성 루푸스 감수성의 연관성

Research Article

Published on 2011-05-262022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Activation addition African American African Americans allelic American amplification Analysis Asian Asians association Author Autoimmune disease Case-control causal variant CFH CFHR1 CFHR3 CFHR4 CFHR5 chromosome chromosome 1q32 complement Complement activation complex contribute datasets Deletion described detected disease-associated downstream dysregulated Ethnic groups European Evidence exonic exonic SNPs Factor FIVE Gene genes encoding Genetic variant genetic variants genotypic haplotype analysis heterozygous higher risk homozygous human disease human diseases impair intron Intronic locus Lupus lupus erythematosus multiplex Pathogenesis populations Previous studies previous study probe Protein provide provided Regulation Significant SLE SNP SNPs subject suggested susceptibility systemic systemic lupus erythematosus tested variant variants
[DOI] 10.1371/journal.pgen.1002079 PMC 바로가기 [Article Type] Research Article

A Decline in p38 MAPK Signaling Underlies Immunosenescence in Caenorhabditis elegans

Caenorhabditis elegans에서 p38 MAPK 신호 전달의 감소는 면역 노화의 기초가 됩니다

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] addressed age aging amplify Author Bacteria Bacterial Bacterial infection Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans change conserved cycle death Decline declines Defense defined Deterioration elegan examined exhibit Genetic Host host defense human pathogen humans immune function immunosenescence impair implicated increase in Infection innate immune Innate immunity intestinal intestinal tissue involved leads MAPK mice mitogen mitogen-activated protein kinase molecular basis molecular mechanism motion pathogen pathway phenomenon PMK-1 proliferation promote Protein protein kinase Pseudomonas aeruginosa regulate signaling pathway susceptibility tissue damage turn
[DOI] 10.1371/journal.pgen.1002082 PMC 바로가기 [Article Type] Research Article

A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria

A −436C>심각한 아동기 말라리아와 관련된 인간 FAS 유전자 프로모터의 다형성

Research Article

Published on 2011-05-192022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] 95% confidence interval A allele a major activated affected allele Analysis Anemia Apoptosis applied assigned association Author carried Case-control caused CD69 Cell cell surface receptor cerebral malaria childhood children Community compared complex interplay complications Control Donor ENCODE Endemic Express expression FACS analysis FAS fatality found functional Genetic variant genetic variants genetics Health healthy individual help heterozygote homozygote homozygous Human Human genetics immune regulation immune response immune responses increased expression individual Infection investigated involved life-threatening locus lymphocyte Lymphocytes malaria molecule mononuclear cell mononuclear cells naïve nucleotide Occurrence Odds ratio outcome Pediatric case Peripheral blood Peripheral blood mononuclear cells phenotypic Plasmodium Plasmodium falciparum predisposition programmed cell death promoter promoter region proportion PROTECT Protective protective immune response Replication risk severe severe malaria significantly significantly higher Single nucleotide variant sub-Saharan Africa subgroup surface receptor susceptibility susceptible syndrome T-lymphocyte the disease Transmission dynamics variant West
[DOI] 10.1371/journal.pgen.1002066 PMC 바로가기 [Article Type] Research Article

Field-Caught Permethrin-Resistant Anopheles gambiae Overexpress CYP6P3, a P450 That Metabolises Pyrethroids

현장에서 포착된 퍼메트린 내성 Anopheles gambiae CYP6P3, 피레스로이드를 대사하는 P450 과발현

Research Article

Published on 2008-11-282022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] A. gambiae adaptive adaptive mechanism adaptive mechanisms Alpha alpha-cyano Anopheles gambiae anopheline mosquitoes Author bioassays compounds Critical CYP6P3 cytochrome P450 detect disease spread Efficacy ENCODE enzyme Enzymes Evolution facilitate found Frequency Gene Gene Expression Genetic Health health problem identify individual insect insecticide insecticides Insects involved lead low frequencies malaria malaria vector malaria vector control mechanism Messenger RNA Metabolic resistance metabolise Molecular assay molecular mechanism molecular mechanisms MONITOR natural selection overexpressed P450 pesticide pesticides phenotyped populations public health pyrethroid Pyrethroids receiving recessive allele reducing resistance significantly sub-Saharan Africa Survivors sustainability trait transcript level translated Transmission undergo
[DOI] 10.1371/journal.pgen.1000286 PMC 바로가기 [Article Type] Research Article

Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes

모든 90개의 폐렴구균 혈청형에서 피막 생합성 유전자좌의 유전적 분석

Research Article

Published on 2006-03-102022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Analysis antigenic variation Antisera bacterial pathogen bacterial polysaccharide bacterial polysaccharide biosynthesis system bacterial polysaccharide diversity Bentley Blood capsular biosynthesis capsular biosynthesis gene capsular biosynthesis genes capsular biosynthetic gene capsular biosynthetic genes capsular gene capsular polysaccharide capsular polysaccharide structures capsular polysaccharides capsular serotype Capsule children chromosomal coated coding complement Complete determined different disease DNA DNA sequence effective protein-conjugated Effective vaccines evade Evolution Express genetics host antibodies host antibody human immune response immunochemically immunogenic immunological reactivity introduced invasive bacterial pathogen knowledge locus mechanism molecular Pathogens pneumococcal disease pneumococcus polysaccharide capsule polysaccharide structure polysaccharide vaccine PROTECT S. pneumoniae selected sequence sequences sera serological profile serological profiles serotype serotypes Seven Streptococcus pneumoniae survival target The United States total size United States virulence
[DOI] 10.1371/journal.pgen.0020031 PMC 바로가기 [Article Type] Research Article