Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals following mRNA vaccinationmRNA 백신 접종 후 SARS-CoV-2 미경험 및 회복된 개인에서 뚜렷한 항체 및 기억 B 세포 반응Research Articles Published on 2021-04-152022-09-10 Journal: Science Immunology [Category] MERS, SARS, 변종, 진단, [키워드] addition age analyses antibodies antibody Antigen antigen-specific memory B cells B cells B.1.351 B.1.351 variant Cell cellular cellular response Cellular responses circulating antibodies clinical trials correlated COVID-19 declined demonstrated detectable distribution dose Efficacy Emergency use full-length spike protein highlight immune responses increases in individual individuals memory memory B memory B cell memory B cells mRNA mRNA vaccination mRNA vaccine mRNA vaccines naïve naïve individual Neutralizing titer neutralizing titers no increase novel priming RBD recall Receptor binding domain required response responses robust SARS-CoV-2 SARS-CoV-2 antigens SARS-CoV-2 vaccine second dose serological serology significantly single vaccine Spike protein Spike receptor binding domain subject subjects titers utility Vaccine vaccine dose vaccine-induced immune response [DOI] 10.1126/sciimmunol.abi6950 PMC 바로가기 [Article Type] Research Articles
Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variantB.1.351 SARS-CoV-2 변이체의 감염 및 백신 유도 항체 결합 및 중화Article Published on 2021-04-142022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] additional spike mutation additional Spike mutations Antibody binding Antibody titer Antibody titers B.1 B.1.351 B.1.351 variant binding antibody convalescent COVID-19 patient D614G deletions domain Efficacy emerging variants exhibited humoral Humoral immunity individual individuals Infection Live virus Moderna Mutation neutralization neutralize Neutralizing antibody titer neutralizing antibody titers polyclonal antibodies polyclonal antibody protective humoral immunity raising Receptor-binding domain reduced reduction in retained SARS-CoV-2 SARS-CoV-2 B.1.351 variant SARS-CoV-2 variant SARS-CoV-2 variants sera spike mutation Spike protein the spike protein vaccinated individual Vaccine vaccine-induced antibodies variant Viral viral neutralization [DOI] 10.1016/j.chom.2021.03.009 PMC 바로가기 [Article Type] Article
Introduction of SARS-CoV-2 variant of concern 20h/501Y.V2 (B.1.351) from Malawi to Italy말라위에서 이탈리아로 우려되는 SARS-CoV-2 변종 20h/501Y.V2(B.1.351) 도입Case Reports Published on 2021-04-092022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 변종, [키워드] 20h/501Y.V2 African B.1.1.351 B.1.351 COVID-19 imported case Italy male returned SARS-CoV-2 SARS-CoV-2 variant South African variant symptomatic variant of concern VoC VOC 202012/02 [DOI] 10.1080/22221751.2021.1906757 PMC 바로가기 [Article Type] Case Reports
Cross-Reactive Neutralizing Antibody Responses Elicited by SARS-CoV-2 501Y.V2 (B.1.351)Correspondence Published on 2021-04-072022-10-04 Journal: The New England Journal of Medicine [Category] MERS, SARS, 진단, [키워드] 501Y.V2 B.1.351 response SARS-CoV-2 [DOI] 10.1056/NEJMc2104192 PMC 바로가기 [Article Type] Correspondence
Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351Correspondence Published on 2021-04-072022-10-04 Journal: The New England Journal of Medicine [Category] MERS, SARS, 변종, 진단, [키워드] B.1.351 B.1.429 SARS-CoV-2 [DOI] 10.1056/NEJMc2103740 PMC 바로가기 [Article Type] Correspondence
The Impact on Infectivity and Neutralization Efficiency of SARS-CoV-2 Lineage B.1.351 PseudovirusSARS-CoV-2 계통 B.1.351 슈도바이러스의 감염성 및 중화 효율에 미치는 영향Communication Published on 2021-04-072022-09-01 Journal: Viruses [Category] MERS, SARS, 변종, 진단, [키워드] affected antibody B.1.351 Casirivimab D614G E484K E484K mutation E484K mutations Efficacy Efficiency Imdevimab Impact indicated Infectivity investigated K417N K417N and E484K mutation of spike Lineage monoclonal antibodies multiple mutation multiple mutations mutant Mutation N501Y N501Y mutation neutralization neutralized Neutralizing antibodies pseudovirus pseudoviruses raising RBD Receptor-binding domain referred to SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant significantly increased South Africa Strains tested the receptor-binding domain Transmissibility variant of SARS-CoV-2 Viral viral infectivity viral spread Wuhan Wuhan strain [DOI] 10.3390/v13040633 PMC 바로가기 [Article Type] Communication
Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016Report Published on 2021-04-052022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, [키워드] Abstract addition Affect amino acid change antibody Antibody binding antibody cocktail antibody escape antigenic evolution B.1.351 B.1.429 bamlanivimab binding circulating Combination Complete coronavirus disease COVID-19 deep mutational scanning E484K Effect Efficacy effort epitope Evolution highlight identify individual Interpretation L452R Lineage LY-CoV555 Map monoclonal antibody Mutation P.1 Prophylaxis RBD SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 mutation SARS-CoV-2 RBD spike receptor-binding domain the SARS-CoV-2 therapeutic Therapeutic antibody variants of concern Variation [DOI] 10.1016/j.xcrm.2021.100255 PMC 바로가기 [Article Type] Report
Linked transmission chains of imported SARS-CoV-2 variant B.1.351 across mainland France, January 20212021년 1월 프랑스 본토 전역에서 수입된 SARS-CoV-2 변종 B.1.351의 연결된 전송 체인Case Reports Published on 2021-04-012022-09-10 Journal: Eurosurveillance [Category] MERS, SARS, 변종, [키워드] African B.1.351 B.1.351 variant Characteristics Cluster comparable COVID-19 described effective Epidemiology FIVE France imported cases Incubation investigation lack measure reported responsible SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants 20H/501Y.V2 South Transmission variant [DOI] 10.2807/1560-7917.ES.2021.26.13.2100333 PMC 바로가기 [Article Type] Case Reports
Effects of SARS-CoV-2 variants on vaccine efficacy and response strategies백신 효능 및 대응 전략에 대한 SARS-CoV-2 변이체의 효과Review Published on 2021-04-012022-09-11 Journal: Expert review of vaccines [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect analyzed Area AstraZeneca B.1.1.7 B.1.351 Clinical studies clinical trial clinical trials coronavirus current Decreased doses Effect Efficacy Emergency use expert immune evasion Johnson & Johnson Johnson & Johnson neutralization Neutralizing antibodies neutralizing antibody nine Novartis pandemic Prevention and control Protective protective efficacy reported respiratory SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 vaccine SARS-CoV-2 variant several variant several variants shown Spread strain suggested the SARS-CoV-2 Transmission vaccination Vaccine vaccine immunogenicity Vaccines variant variants widespread [DOI] 10.1080/14760584.2021.1903879 PMC 바로가기 [Article Type] Review
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity Research Published on 2021-04-012022-10-05 Journal: Nature [Category] SARS, 변종, 유전자 메커니즘, 진단, 치료기술, [키워드] adjuvant adjuvants AS03 B.1.1.7 SARS-CoV-2 variant B.1.351 B.1.351 variant breadth Bronchoalveolar lavage CD4 clinical trial correlated COVID-19 vaccine domain Efficacy evaluated FIVE HexaPro highlight immunization immunized immunogenic induce Infection Live virus nare neutralization Neutralizing-antibody produced protective immunity Protein public health reduced reduction in response rhesus macaques robust SARS-CoV-2 SARS-COV-2 infection Spike protein stimulate subunit T cell responses the SARS-CoV-2 TLR7 TLR9 toll-like receptor 7 vaccinate vaccination Vaccine [DOI] 10.1038/s41586-021-03530-2 [Article Type] Research