Evaluating performance of existing computational models in predicting CD8+ T cell pathogenic epitopes and cancer neoantigensCD8+ T 세포 병원성 에피토프 및 암 신생항원 예측에서 기존 컴퓨터 모델의 성능 평가Article Published on 2022-05-132022-09-12 Journal: Briefings in Bioinformatics [Category] MERS, 진단, [키워드] acute respiratory syndrome binding affinity Cancer cancer neoantigen cancers CD8 T-cell CD8 T-cell target CD8+ T cell coronavirus disease distribution epitope evaluated Evaluating Evidence facilitate Factor feature highlight histocompatibility complex HLA ligand immunogenic immunogenic peptide immunotherapies Immunotherapy Intensive long-term immune responses malignant cell modulate offer parameter pathogen pathogenic pathology peptide peptide immunogenicity peptide presentation peptides predictors question random Research robust stability suggested T cell T cell receptor T-cell T-cell Response target threshold training data Vaccine Variation virus [DOI] 10.1093/bib/bbac141 PMC 바로가기 [Article Type] Article
Safety and Immunogenicity of Inactivated and Recombinant Protein SARS-CoV-2 Vaccines in Patients With Thyroid Cancer갑상선암 환자에서 비활성화 및 재조합 단백질 SARS-CoV-2 백신의 안전성 및 면역원성Observational Study Published on 2022-05-132022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] acute respiratory syndrome Adults All participant BBIBP-CorV booster vaccination Cancer cancer patient Cancer patients Chongqing Complication CoronaVac coronavirus Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) dose Fever FIVE healthy humoral immunogenicity inactivated Inactivated SARS-CoV-2 vaccine injection site pain participant Patient ranged recombinant Safe Safety SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 IgG antibody SARS-CoV-2 vaccination SARS-CoV-2 vaccine second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Side effect significantly significantly shorter the SARS-CoV-2 Thyroid university vaccination Vaccine was tested were recorded ZF2001 [DOI] 10.3389/fimmu.2022.855311 PMC 바로가기 [Article Type] Observational Study
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review
Impaired immune responses in blood cancers improved by third COVID-19 vaccine dose News & Views Published on 2022-05-112022-10-05 Journal: Nature cancer [Category] COVID19(2023년), SARS, 임상, 치료법, [키워드] Blood Cancer COVID-19 vaccine dose immune response Impaired [DOI] 10.1038/s43018-022-00369-y [Article Type] News & Views
Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery SystemsReview Published on 2022-05-092022-10-04 Journal: ACS Biomaterials Science & Engineering [Category] 신약개발, [키워드] Administered allergies approach Autoimmune diseases Cancer Cell COVID-19 delivery Dexamethasone disease Diseases disorders drug drug delivery Drug repurposing Effect elicit healthy hyperglycemia hypertension inhibiting insight nanomaterials ocular organ phosphate polymers provide Research Side effects System tissue tissue engineering treat variety [DOI] 10.1021/acsbiomaterials.2c00026 PMC 바로가기 [Article Type] Review
The clinical progress of mRNA vaccines and immunotherapies Reviews Published on 2022-05-092022-10-05 Journal: Nature biotechnology [Category] 임상, [키워드] acute respiratory syndrome addition administration booster building Cancer cellular coronavirus coronavirus disease COVID-19 doses drugs effective Emergency use authorization Epstein–Barr virus highlight HIV Human immunodeficiency virus immune stimulation immunostimulatory Immunotherapy Infectious disease inherent Local MOST mRNA mRNA vaccine mRNA-based nucleic acid Protein protein expression repeated Seasonal influenza sequence target cell therapy tissues translation Vaccine Vaccines [DOI] 10.1038/s41587-022-01294-2 [Article Type] Reviews
COVID-19 Outcomes Among Patients With Cancer: Observations From the University of California Cancer Consortium COVID-19 Project Outcomes RegistryArticle Published on 2022-05-062023-07-08 Journal: The oncologist [Category] COVID19(2023년), [키워드] Cancer COVID-19 Mortality [DOI] 10.1093/oncolo/oyac038 PMC 바로가기
The Current Landscape of mRNA Vaccines Against Viruses and Cancer-A Mini Review바이러스 및 암에 대한 mRNA 백신의 현재 상황-A 미니 리뷰Review Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] 유전자 메커니즘, [키워드] Against Cancer cancer vaccination cancers cause clinical development clinical trial clinical trials clinical trials of mRNA vaccines COVID-19 pandemic current death example flexible landscape limitation MINI molecular mechanisms mRNA mRNA modifications mRNA vaccine mRNA vaccine delivery mRNA vaccine developers mRNA vaccine mechanism mRNA vaccines mRNA-based multiple antigen multiple antigens Patient Personalized medicine platform Research review therapy Treatment vaccination vaccine platform viral disease viral infection viral infections viral vaccination. viruses [DOI] 10.3389/fimmu.2022.885371 PMC 바로가기 [Article Type] Review
Synthesis and in vitro Study of Artemisinin/Synthetic Peroxide-Based Hybrid Compounds against SARS-CoV-2 and CancerSARS-CoV-2 및 암에 대한 아르테미시닌/합성 과산화물 기반 하이브리드 화합물의 합성 및 시험관 내 연구Article Published on 2022-05-042022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 치료제, [키워드] active against acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-cancer compounds anti-leukemia agents anti-SARS-CoV-2 anti-SARS-CoV-2 compounds antiviral agent Antiviral agents Artemisinin artemisinin based hybrids. artesunic acid Cancer Cell cell lines Compound coronavirus cytotoxic effect cytotoxic effects demonstrated disease Doxorubicin drug effective hybrid hybrid drug in vitro in vitro activity Infection inhibitory activity leukemia life-threatening Patients with cancer peroxide quinoline reported SARS-CoV-2 SARS-CoV-2 infections selectivity severe acute respiratory syndrome Coronavirus synthesis treat Vero E6 Vero E6 cell VERO E6 cells while [DOI] 10.1002/cmdc.202200005 PMC 바로가기 [Article Type] Article
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer Research Published on 2022-05-042022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] appear applied approach ARHGAP26 Cancer Cell CHAF1A CNPPD1 collected complex complex disease Critical database dataset death diabete diagnostic differentially expressed gene Differentially expressed genes disease disease onset DLC1 enriched pathways event FDX1 gene expression dataset Gene expression profiling information Interaction ITGBL1 kidney Kidney diseases LAMP2 MAP3K13 MAPK molecular MTO1 NSMAF pathophysiology pathway phenotype PPP2R5E progression PRSS23 receptor renal Research reveal SCARB2 Stage STAMBP survival SYNJ1 tight junction TPGS2 YY1 [DOI] 10.1038/s41598-022-11143-6 [Article Type] Research