Antibodies Targeting Two Epitopes in SARS-CoV-2 Neutralize Pseudoviruses with the Spike Proteins from Different VariantsCommunication Published on 2021-07-092022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] Alpha variant Analysis antibody B-cell epitope Beta Beta variant caused COVID-19 COVID-19 pandemic D614G effective epitope IgG immunize information linear neutralization neutralize Particle peptide Point mutation prevalent Prevent produced Protective pseudovirus purified required SARS-CoV SARS-CoV-2 SARS-COV-2 infection Spike protein Spread targeting the Spike the spike protein Vaccine variant variants wild-type [DOI] 10.3390/pathogens10070869 PMC 바로가기 [Article Type] Communication
The interplay of SARS-CoV-2 evolution and constraints imposed by the structure and functionality of its proteinsResearch Article Published on 2021-07-082022-10-28 Journal: PLoS Computational Biology [Category] COVID-19, SARS, [키워드] 3D structure accumulate amino acid changes Analysis antibodies avoidance coded conserved correlated COVID-19 test develop dominant driving drugs encoded proteins epitope example explained Factor faster feature Features function functional Genetic genetic change Genome genomic region high mutation rate high variability host immunity implication in viral information less Missense mutation mutated Mutation natural selection Neutral observation Organisms pandemic pathogen PCR probes Protein protein-coding genes protein-protein interaction provide Region regions Requirement resulting risk RNA viruses SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 proteins Sequencing specific antibody Taking target region the SARS-CoV-2 virus three-dimensional structure unique Vaccine Vaccine design viral evolution Viral genetics viral genome virulent virus while [DOI] 10.1371/journal.pcbi.1009147 PMC 바로가기 [Article Type] Research Article
Immunoinformatics approach for multi-epitope vaccine design against structural proteins and ORF1a polyprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)Research Published on 2021-07-082022-10-28 Journal: Tropical Diseases, Travel Medicine and Vaccines [Category] COVID-19, [키워드] acute respiratory syndrome amino acid sequence amino acids antigenic antigenicity approach candidate vaccine carried catastrophic cell-mediated immune chimeric clone coronavirus Coronavirus-2 COVID-19 CTL epitope docking E protein effective epitope Epitopes expression Final Health HTL epitope humoral IEDB immunoinformatics lack M protein molecular Multi-epitope Multi-epitope vaccine N protein ORF1a physicochemical property Plasmid polyprotein predict Protective Protein Proteins ProtParam tool Result S protein SARS-CoV-2 structural protein the vaccine TLR3 Treatment Vaccine Viral protein were used while [DOI] 10.1186/s40794-021-00147-1 PMC 바로가기 [Article Type] Research
Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern에피토프 특이적 항체 반응으로 COVID-19 결과와 우려 변종 차별화Clinical Medicine Published on 2021-07-082022-09-10 Journal: JCI Insight [Category] SARS, 변종, 진단, 치료법, [키워드] Action antibody antibody profiling Antibody Response Antibody responses Antibody testing Antigen antigens B.1.1.7 Clinical outcome Clinical severity complex complexity coronavirus COVID-19 detect develop epitope epitope peptide Epitopes foundation Health Sciences high resolution High-resolution Humoral immunity identify immunoassay immunoglobulins Infection Infectious disease Innovation linear epitope linear epitopes London Microarrays Mutation N protein Neutralizing Neutralizing antibodies Non-neutralizing antibodies nucleocapsid ORF organization outcome P681H patient survival peptide peptides plasma sample plasma samples positively correlated predict produced Protein Rapid SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 proteome Science screened serology test serology tests specificity the SARS-CoV-2 Toronto university variant variants variants of concern [DOI] 10.1172/jci.insight.148855 PMC 바로가기 [Article Type] Clinical Medicine
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization Research Published on 2021-07-082022-10-05 Journal: Nature [Category] 변종, [키워드] Alpha variant anti-RBD antibody Antibody neutralization AstraZeneca B.1.1.7 B.1.617 B.1.617.2 binding collected convalescent individual convalescent individuals COVID-19 COVID-19 vaccine Delta delta variant dominant dose epitope examined faster France immune evasion include India individual individual with COVID-19 individuals inhibitory effect less Lineage monoclonal antibodies monoclonal antibody Mutation N-terminal domain neutralization Neutralizing NTD onset of symptom other variants Pfizer RBD Region returned SARS-CoV-2 SARS-CoV-2 variant sensitivity sera Spike protein Spread spread to strain subtype the receptor-binding domain the SARS-CoV-2 the spike protein the vaccine titre Vaccine variants [DOI] 10.1038/s41586-021-03777-9 [Article Type] Research
Potent RBD-specific neutralizing rabbit monoclonal antibodies recognize emerging SARS-CoV-2 variants elicited by DNA prime-protein boost vaccinationResearch Article Published on 2021-07-082022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] Analysis B.1.1.7 B.1.351 B.1.351 variants B.1.429 B.1.526 boost COVID-19 D614G diagnostic DNA DNA vaccine domain effective elicited epitope Epitopes heterologous prime-boost immunization host immunity induce Measures monoclonal antibody neutralization neutralization potency neutralize Neutralizing overlapping P.1 point-of-care potent priming Protein pseudovirus rabbit mAb RBD RBD protein recognize S1 protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant SARS-CoV-2 WT Sequence analysis Spike protein tested the SARS-CoV-2 vaccination Vaccine variant Variant of concerns variants virus wild type [DOI] 10.1080/22221751.2021.1942227 PMC 바로가기 [Article Type] Research Article
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodiesArticle Published on 2021-07-072022-10-29 Journal: Nature Communications [Category] COVID-19, SARS, [키워드] affected Anti-RBD antibody antibodies antibody binding convalescent domain epitope Epitopes Evolution High-resolution Human immune system Human monoclonal antibody identify include individual infected with SARS-CoV-2 Infection mapping Mutation neutralization Neutralizing plasma plasma antibody plasmas polyclonal RBD relative contribution SARS-CoV-2 SARS-CoV-2 mutant skewed structures the antibody the RBD the SARS-CoV-2 variety viral evolution viral infection viral spike while [DOI] 10.1038/s41467-021-24435-8 PMC 바로가기 [Article Type] Article
Electrostatic Interactions Explain the Higher Binding Affinity of the CR3022 Antibody for SARS-CoV-2 than the 4A8 Antibody정전기 상호작용은 4A8 항체보다 SARS-CoV-2에 대한 CR3022 항체의 더 높은 결합 친화도를 설명합니다Article Published on 2021-07-062022-09-12 Journal: The journal of physical chemistry. B [Category] SARS, 진단, [키워드] affinity Amino acid amino acids antibody approach atomic level bind binding affinity candidate coarse-grained simulation coarse-grained simulations complexes Contact contact with COVID-19 therapy CR3022 domain effective electrostatic interaction electrostatic interactions epitope experiments explain higher affinity Interaction mechanism molecular molecular dynamics monoclonal antibodies monoclonal antibody N-terminal domain NTD RBD reveal SARS-CoV-2 SARS-CoV-2 RBD SMD the binding affinity the SARS-CoV-2 therapy treat virus [DOI] 10.1021/acs.jpcb.1c03639 PMC 바로가기 [Article Type] Article
Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronavirusesResearch Article Published on 2021-07-022022-10-31 Journal: Computational and Structural Biotechnology Journal [Category] COVID-19, [키워드] Abstract antibody cross-reactivity bioinformatics Comparisons coronavirus coronavirus spike protein COVID-19 docking effort epitope example facilitate help highly pathogenic Host host protein Human human coronavirus human protein humans Infection Infectious disease Interaction interaction partner MERS-CoV motif motifs overlapping pathway Plasmodium falciparum Potential Protein Proteins receptor-binding motif returned SARS-CoV SARS-CoV-2 sequence homology shown Spike proteins structural bioinformatics the SARS-CoV-2 the spike protein Vaccine viral host mimicry virus [DOI] 10.1016/j.csbj.2021.06.041 PMC 바로가기 [Article Type] Research Article
Development of Bacteriophage Virus-Like Particle Vaccines Displaying Conserved Epitopes of Dengue Virus Non-Structural Protein 1Article Published on 2021-07-022023-08-29 Journal: Vaccines [Category] E형 간염, [키워드] bacteriophage dengue virus ELISA epitope immunization non-structural protein 1 Vaccine Virus-like particle VLP [DOI] 10.3390/vaccines9070726 PMC 바로가기 [Article Type] Article