SARS-CoV-2 spike
[용어속성] Term
SARS-CoV-2 and Viral Sepsis: Immune Dysfunction and Implications in Kidney Failure
Review
[키워드] abdominal pain
ACE-2
Acute cardiac injury
Acute kidney injury
acute respiratory distress
acute respiratory syndrome
addition
affected
AKI
antiviral medicine
ARDS
binding
cardiovascular complication
Cell
clinical manifestation
Clinical outcome
co-morbidity
coronavirus
coronavirus disease
cough
COVID-19
COVID-19 patient
dysfunction
Dyspnea
effective
Endothelial dysfunction
Evidence
exacerbate
explained
failure
Fever
Host
human Angiotensin-converting enzyme
Hyperinflammatory
ICU
include
infected with COVID-19
Inflammatory response
inhibit
intensive care unit
Intervention
kidney dysfunction
lung
mechanism
modulate
Mounting
multi-organ failure
Occurrence
organ
outcome
overexpression
pathogenic mechanism
Patient
pro-inflammatory cytokine
Probability
receptor
renal
renal dysfunction
renal impairment
reported
Respiratory disease
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike
Sepsis
severe COVID-19
Severe patient
severity
shown
Support
syndrome
systemic inflammatory response
the cytokine storm
the disease
treating COVID-19
Vaccine
viral cytopathic effect
viral entry
viral replication
Wuhan, China
[DOI] 10.3390/jcm9124057 PMC 바로가기 [Article Type] Review
[DOI] 10.3390/jcm9124057 PMC 바로가기 [Article Type] Review
Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains
ACE2가 있거나 없는 SARS-CoV-2 스파이크의 Cryo-EM 구조는 수용체 결합 도메인의 엔도솜 위치를 매개하는 pH 의존적 스위치를 나타냅니다
Article
[키워드] absence
ACE2
ACE2 binding
ACE2 receptor
adopted
Affect
alteration
binding antibody
conformation
COVID-19
Cryo-electron microscopy
domain
domains
endosomal
endosomal entry
engage
facilitate
human ACE2 receptor
immune evasion
Interaction
occur
Pathways
pH-dependent switch
positioning
RBD
RBDs
Receptor-binding domain
Receptor-binding domain (RBD)
required
SARS-CoV-2
SARS-CoV-2 spike
serological
spike
structural rearrangement
Structure
switch
trimer
type 1 fusion machine.
virus entry
[DOI] 10.1016/j.chom.2020.11.004 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.chom.2020.11.004 PMC 바로가기 [Article Type] Article
SARS-CoV-2 spike protein binds to bacterial lipopolysaccharide and boosts proinflammatory activity
Articles
[키워드] Activation
aggregation
Analysis
Bacterial
bacterial lipopolysaccharide
bind
Blood
boost
Cell
Comorbidity
COVID-19
cytokine response
demonstrated
dynamic
excessive inflammation
gel electrophoresis
in vitro
in vivo
infection with SARS-CoV-2
Inflammation
Inflammatory response
Interaction
lipopolysaccharide
LPS
metabolic syndrome
mice
modulated
molecular
Molecular dynamics simulation
mononuclear cells
Native
NF-κB
nuclear
Patient
Peripheral blood
proinflammatory
Protein
reporter
S protein
SARS-CoV-2
SARS-CoV-2 S protein
SARS-CoV-2 spike
SARS-CoV-2 spike protein
scattering
severe COVID-19
Spike protein
syndrome
THP-1
transmission electron microscopy
[DOI] 10.1093/jmcb/mjaa067 PMC 바로가기 [Article Type] Articles
[DOI] 10.1093/jmcb/mjaa067 PMC 바로가기 [Article Type] Articles
A protocol for displaying viral envelope glycoproteins on the surface of vesicular stomatitis viruses
Protocol
[키워드] Abstract
can be used
Cell
Cell culture
Cell-based Assays
displaying
expressing
genomic RNA
glycoprotein
Heterologous
HIV-1
immunology
Infection
Molecular biology
not carry
Particles
Plasmid
protocol
recombinant
replication-competent viruses
SARS-CoV-2 spike
stomatitis
Vaccine
viral entry
viral envelope
Viral proteins
virus
Virus neutralization
VSV
[DOI] 10.1016/j.xpro.2020.100209 PMC 바로가기 [Article Type] Protocol
[DOI] 10.1016/j.xpro.2020.100209 PMC 바로가기 [Article Type] Protocol
SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
SARS-CoV-2 스파이크 단백질은 상피 세포에서 지오텐신 II 수용체 신호 전달의 활성화에 의해 IL-6 트랜스 신호 전달을 촉진합니다
Research Article
[키워드] ACE2
ACE2 expression
Activation
acute respiratory distress
acute respiratory distress syndrome
ADAM
Aggressive
angiotensin
angiotensin converting enzyme
Angiotensin converting enzyme-2
Angiotensin II
AP-1
AT1
Author
c-Fos
candesartan
Candesartan cilexetil
cascade
Cell
cell interactions
cells
Characteristics
chemokines
classical
combating
coordination
Coronavirus infection
COVID-19
COVID-19 disease
COVID-19 disease severity
culture supernatant
cytokine
cytokine response
Cytokine storm
Cytokines
disease severity
down-regulation
ectopic expression
elevated
endothelial
Endothelial cell
epithelial
epithelial cell
epithelial cells
excessive inflammatory response
expressed
expressing
expression
Extracellular
generate
Host
human epithelial cell
human epithelial cells
human liver
hyper-inflammatory response
IL-6
IL-6R
indicated
induce
inducer
Infection
Inflammatory cytokine
inhibit
inhibited
Interaction
leads
Lung epithelial cells
Lung injury
Macrophage
macrophage activation
macrophages
MAPK
MCP-1
mechanism
mediators
Monocytes
monocytes/macrophage
monocytes/macrophages
Multi-organ damage
NF-κB
observation
pathology
pathway
patient sera
Phosphorylation
primary host
pro-inflammatory
promote
promoted
promotion
protease
protein expression
pulmonary epithelial cell
receptor
receptor antagonist
receptor protein
receptor signaling
referred to
Regulatory
residue
respiratory distress
Respiratory distress syndrome
SARS Coronavirus
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 spike
SARS-CoV-2 spike protein
secretion
Signaling
SOCS3
soluble IL-6R
Spike protein
STAT3
suggested
syndrome
therapeutic
therapeutic intervention
tissue damage
trans
trans-signaling
transcriptional
transmembrane
vascular endothelial cell
Viral
viral infection
viral spike protein
with COVID-19
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1009128 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids
Short Article
[키워드] ACE2-expressing cell
acute respiratory syndrome
Apolipoprotein
barrier
blood-CSF-barrier
Brain
brain organoid
caused
Cell
cell types
Cerebral organoids
cerebrospinal fluid
choroid
choroid plexus organoids
Complication
coronavirus
Coronavirus disease 2019
COVID-19
COVID-19 patients
cytokine
epithelial
epithelial cell
expressed
expressing
expression
Glia
Human
immune cells
Increasing
infect
infected cell
Infection
infection with SARS-CoV-2
Lipoproteins
Live virus
Neurological symptom
Neuron
neurons
Organoid
Pathogens
patients
Plexus
Prevent
pseudovirus
receptor ACE2
respiratory symptom
SARS-CoV-2
SARS-CoV-2 entry factor
SARS-COV-2 infection
SARS-CoV-2 neurotropism
SARS-CoV-2 spike
significantly
susceptible
viral tropism
virus
[DOI] 10.1016/j.stem.2020.10.001 PMC 바로가기 [Article Type] Short Article
[DOI] 10.1016/j.stem.2020.10.001 PMC 바로가기 [Article Type] Short Article
Ultra-Sensitive Serial Profiling of SARS-CoV-2 Antigens and Antibodies in Plasma to Understand Disease Progression in COVID-19 Patients with Severe Disease
중증 질환이 있는 COVID-19 환자의 질병 진행을 이해하기 위한 혈장 내 SARS-CoV-2 항원 및 항체의 초민감 직렬 프로파일링
Article
[키워드] 95% CI
acute respiratory syndrome
acute respiratory syndrome coronavirus
analyzed
anti-SARS-CoV-2
Antigen
Biomarker
Blood
changes in
clearance
clinical outcomes
Clustering
Combined
Concentration
coronavirus
coronavirus disease
COVID-19
COVID-19 case
COVID-19 negative
COVID-19 positive patients
detect
detectable
Disease progression
Hierarchical
hierarchical clustering
ICU admission
identify
Infection
intubation
longitudinal plasma samples
molecule
MONITOR
N antigen
nasopharyngeal
nucleocapsid antigen
nucleocapsid antigens
Patient
patients
patients with COVID-19
PCR
plasma
plasma sample
positive
positive result
Profiling
quantified
reported
respiratory
Respiratory failure
RT-PCR test
S1 subunit
SARS-CoV-2
SARS-CoV-2 antigen
SARS-CoV-2 S1
SARS-CoV-2 spike
SARS-CoV-2 viral
Seroconversion
serological
serological assays
serology tests
severe acute respiratory syndrome Coronavirus
severe acute respiratory syndrome coronavirus 2
severe disease
Simoa
single molecule arrays
statistically significant
test results
These data
Viral
Viral antigen
viral antigens
[DOI] 10.1093/clinchem/hvaa213 PMC 바로가기 [Article Type] Article
[DOI] 10.1093/clinchem/hvaa213 PMC 바로가기 [Article Type] Article
Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2
감기 코로나바이러스와 SARS-CoV-2에 대한 건강한 기증자 T 세포 반응
Clinical Trial
[키워드] 229E
acute respiratory syndrome
acute respiratory syndrome coronavirus
acute respiratory syndrome coronavirus 2
Adaptive immunity
Cell
characterized
circulating
common cold
common cold coronavirus
common cold Coronaviruses
coronavirus
coronavirus disease
Coronavirus disease 2019
COVID-19
Culture
determine
Donor
donors
ELISPOT
ELISpot assay
enzyme
enzyme-linked immunospot
exposure to
had no
HCoV
HCoV-229E
HCoV-NL63
HCoV-OC43
healthy donor
Immunity
immunology
in vitro
Infectious disease
influence
memory T
memory T cell
NL63
Novel coronavirus
nucleocapsid protein
Nucleocapsid proteins
OC43
outcomes
peptide
peptide pool
peptide pools
peptides
Recognition
recognize
reported
response
SARS-CoV-2
SARS-CoV-2 spike
SARS-CoV-2 spike protein
seronegative
severe acute respiratory syndrome Coronavirus
Spike protein
Spike proteins
suggested
T cell
T cell response
T cell responses
T cells
the spike protein
virus
[DOI] 10.1172/JCI143120 PMC 바로가기 [Article Type] Clinical Trial
[DOI] 10.1172/JCI143120 PMC 바로가기 [Article Type] Clinical Trial
Establishment of Murine Hybridoma Cells Producing Antibodies against Spike Protein of SARS-CoV-2
Article
[키워드] acute respiratory syndrome
addition
Amino acid
antibodies
antibody
caused
Cell
coronavirus
COVID-19
COVID19
denatured
detect
diagnose
enzyme-linked immunosorbent
heavy chain
hybridoma
immunofluorescence
in vitro experiments
information
mAb
mAbs
molecular
monoclonal antibodies
monoclonal antibody
mutations
neutralization
pandemic of COVID-19
peptide
Protein
Receptor binding domain
S protein
SARS-CoV-2
SARS-COV-2 infection
SARS-CoV-2 protein
SARS-CoV-2 spike
sequence
spike
spike RBD
Spread
staining
tested
the disease
therapeutic
tissue samples
Treatment
virus
[DOI] 10.3390/ijms21239167 PMC 바로가기 [Article Type] Article
[DOI] 10.3390/ijms21239167 PMC 바로가기 [Article Type] Article