Changes in Alcohol Consumption during the COVID-19 Pandemic Are Dependent on Initial Consumption Level: Findings from Eight European CountriesArticle Published on 2021-10-082022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, SARS, [키워드] alcohol alcohol consumption AUDIT-C change changes in comparison conducted Consumption COVID-19 COVID-19 pandemic decile declining Denmark Dependent Drinking eight Europe European finding Germany group groups heavy drinking highest initial investigated Norway pandemic Poland polarization Prevalence restrictions Seven significantly Spain survey translate used data were measured [DOI] 10.3390/ijerph181910547 PMC 바로가기 [Article Type] Article
WIN 55,212-2 shows anti-inflammatory and survival properties in human iPSC-derived cardiomyocytes infected with SARS-CoV-2Cell Biology Published on 2021-10-082022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] “cytokine storm” acute respiratory syndrome Angiotensin-converting enzyme Anti-inflammatory anti-inflammatory property cannabinoid cannabinoids caused complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients Effect eight hallmark heart tissue high risk Human iPSC-derived cardiomyocytes infect infected cells infected with SARS-CoV-2 Inflammation Inflammatory Injury investigated lactate dehydrogenase LDH manifestation modify modulating Mortality myocardial injury organs pro-inflammatory cytokines protein levels reduced reducing released Replication SARS-CoV-2 SARS-COV-2 infection severe COVID-19 survival therapeutic TNF-α triggered tumor necrosis factor-alpha viral infection WIN 55,212-2 [DOI] 10.7717/peerj.12262 PMC 바로가기 [Article Type] Cell Biology
PABPC4 Broadly Inhibits Coronavirus Replication by Degrading Nucleocapsid Protein through Selective AutophagyResearch Article Published on 2021-10-062022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, [키워드] activate addition alphacoronavirus Antiviral antiviral response Antiviral strategies autolysosome autophagy coronavirus Coronaviruses CoV CoV replication CoVs cytoplasmic Degradation demonstrated develop Diseases drug E3 ubiquitin ligase eight Gene Expression help Host host protein Human IFN increase inhibit inhibiting interact isoform mRNA stability N protein nucleocapsid PABPC4 pathway Protein receptor recruited regulated Replication restriction factor resulting selective selective autophagy severe disease signaling pathway significantly SP1 suppresse the Coronaviridae the interferon the N protein Therapies These data transcription factor SP1 translation Vaccine viral infection viral proliferation viral replication virus [DOI] 10.1128/Spectrum.00908-21 PMC 바로가기 [Article Type] Research Article
Impact of the stringency of lockdown measures on covid-19: A theoretical model of a pandemicResearch Article Published on 2021-10-052022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] Analysis analyzed Belgium Comparative Contact Contagion dataset death rates demographics diabete downloaded effective eight Factor analysis France GDP Germany growth Health hospital ICU Impact index indicated Infection infection rate infection rates Italy Latent lockdown Logistic measure median age Mortality mortality data mortality rate mortality rates Multiple Multiple regression Netherlands pandemic path Population Prevalence produced reducing residual Result root Schools significant effect Spain Spread square Travel United Kingdom variable variables virus vulnerability was tested [DOI] 10.1371/journal.pone.0258205 PMC 바로가기 [Article Type] Research Article
COVID-19 Infection Alters the Microbiome: Elite Athletes and Sedentary Patients Have Similar Bacterial FloraClinical Trial Published on 2021-10-042022-10-04 Journal: Genes [Category] MERS, SARS, 임상, [키워드] all subject Alter Analysis athlete Bacterial Bacteroidete Bacteroidetes collected competing COVID-19 COVID-19 infection COVID-19 PCR test diagnosed Diagnosis Efficiency eight elevated Elite exercise female females FIVE Flora Hypothesis immune system individuals Infection Inflammation male Microbiome Mild Mild symptom National Negative PCR no difference PCR test positive pro-inflammatory cytokines quarantine regular exercise reported Severe COVID-19 Infection Signaling Significant statistical analysis subject subjects suggested suppress tested toll-like receptor 4 were used [DOI] 10.3390/genes12101577 PMC 바로가기 [Article Type] Clinical Trial
Shoulder Pain in COVID-19 Survivors Following Mechanical VentilationCase Report Published on 2021-10-032022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] affected Anatomy caused clinical evaluation complementary COVID-19 eight hospital Hospitalized ICU intensive care unit intubation joint Mechanical mechanical ventilation Muscle strength Musculoskeletal Neurological deficit on mechanical ventilation Pain Patient patients peripheral nervous systems physical positive presenting Prone position proportion rehabilitation released Seven shoulder Shoulder Pain with COVID-19 [DOI] 10.3390/ijerph181910434 PMC 바로가기 [Article Type] Case Report
A retrospective multi-center experience of renal transplants from India during COVID-19 pandemicObservational Study Published on 2021-10-012022-10-05 Journal: Clinical transplantation [Category] SARS, 임상, [키워드] Analysis Asymptomatic case fatality ratio coronavirus Coronavirus disease 2019 COVID-19 COVID-19 infection COVID-19 pandemic death eight incidence of COVID-19 India Infection initial kidney kidney transplant Kidney transplantation likelihood lockdown median multivariable logistic regression Odds ratio Older age outcome outcomes pandemic Patient Primary outcome renal retrospective SARS-CoV-2 study period survival symptomatic the patient Transplant [DOI] 10.1111/ctr.14423 PMC 바로가기 [Article Type] Observational Study
COVID-19 antibody donation using immunoadsorption: Report of two cases면역흡착을 이용한 코로나19 항체 기증: 2건 보고Case Reports Published on 2021-10-012022-09-12 Journal: Transfusion and apheresis science : official journ [Category] MERS, SARS, 진단, [키워드] anti-SARS-CoV-2 antibodies antibody Antibody donation applied Autoimmune diseases benefit can be used Clinical efficacy coagulation factor component Concentration convalescent COVID-19 COVID-19 antibody COVID-19 convalescence COVID-19 pandemic Donor eight greater immunization Immunoadsorption Immunoglobulin in sight infected patient majority neutralization neutralized neutralizing antibody performed Peripheral blood plasma plasma unit promote report severe COVID-19 Side effects Standardization tangential flow filtration therapy transfused Treatment trials university Virus neutralization [DOI] 10.1016/j.transci.2021.103193 PMC 바로가기 [Article Type] Case Reports
Myasthenia gravis associated with anti-MuSK antibodies developed after SARS-CoV-2 infectionSARS-CoV-2 감염 후 개발된 항-MuSK 항체와 관련된 중증 근무력증Case Reports Published on 2021-10-012022-09-11 Journal: European journal of neurology [Category] MERS, SARS, 진단, 치료기술, [키워드] Acetylcholine acetylcholine receptor affecting anti-MuSK antibodies antibodies antibody Autoimmune diseases azathioprine CBA cell-based assay Central nervous system clinical response Coronavirus infection correlation described Diagnosis eight element followed by immunohistochemistry immunosuppressive immunosuppressive therapy Infection low-density Low-density lipoprotein mechanism musk myasthenia gravis nervous system Neurological complication Neurological complications neuromuscular junction Novel coronavirus pandemic Patient performed Peripheral nervous system Protein pyridostigmine radioimmunoassay receptor reported RIA SARS-CoV-2 SARS-COV-2 infection secondary to serological serum antibodies serum antibody Symptom the disease the timing therapy treated Treatment Trigger tyrosine viral disease Viral diseases [DOI] 10.1111/ene.14721 PMC 바로가기 [Article Type] Case Reports
Fragment-based in silico design of SARS-CoV-2 main protease inhibitorsSARS-CoV-2 주요 프로테아제 억제제의 단편 기반 in silico 설계Article Published on 2021-10-012022-09-11 Journal: Chemical biology & drug design [Category] SARS, 신약개발, 치료제, [키워드] 3CLpro approach AutoDock AutoDock vina binding binding affinity binding mode binding pocket co-crystallized Compound conformation conformations coronavirus Coronavirus COVID-19 crystal structure domain Drug discovery eight fragment fragment-based drug discovery generate Glide in silico inhibitor interactions linear combination linker main protease Mpro 3CLpro MD simulation MPro multivalency. Precision protease Protein Data Bank provided SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 replication screened selected small molecule Small molecules starting point Structure structures suggested therapeutic strategy were used X-ray X-ray crystal structure [DOI] 10.1111/cbdd.13914 PMC 바로가기 [Article Type] Article