Peptide microarray-based analysis of antibody responses to SARS-CoV-2 identifies unique epitopes with potential for diagnostic test developmentSARS-CoV-2에 대한 항체 반응의 펩티드 마이크로어레이 기반 분석은 진단 테스트 개발 가능성이 있는 고유한 에피토프를 식별합니다.Article Published on 2021-07-012022-09-11 Journal: European Journal of Immunology [Category] SARS, 진단, 치료법, [키워드] 229E Analysis antibody antibody cross-reactivity Antibody Response antibody tests antigens binding capture capture antigen control sample controls coronavirus COVID-19 COVID-19 patient COVID-19 patients cross-reactivity diagnostic diagnostic antibody diagnostics ELISA epitope HCoV HCoVs human coronavirus identify IgG immune protection Immunity immunodominant implication MERS Microarrays nucleocapsid OC43 Patient peptide peptide microarray peptide microarray. peptides provided Region respiratory SARS-CoV-2 SARS-CoV-2 proteome screened statistically significant strain the Spike unique while widespread [DOI] 10.1002/eji.202049101 PMC 바로가기 [Article Type] Article
Nasal delivery of an IgM offers broad protection from SARS-CoV-2 variantsIgM의 비강 전달은 SARS-CoV-2 변종으로부터 광범위한 보호를 제공합니다.Article Published on 2021-07-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 진단, 치료제, [키워드] (alpha (Beta Administered administration Alpha antibody antibody-based therapy B.1.1.7 B.1.351 B.1.351 variants Beta body weight Brazil COVID-19 Critical domain dose effective Efficacy Emergency use ENhance epitope exhibit Gamma IgG IgG antibodies IgG antibody IgM Immunoglobulin Immunoglobulin G immunoglobulin M IMPROVE intranasal intranasally mice mutants neutralize Neutralizing neutralizing antibody offer overcome P.1 parental Prophylactic raised reduce resistance rodents safety profile SARS-CoV-2 SARS-CoV-2 variant single dose South therapeutic therapeutic efficacy Therapeutic treatment variant virus [DOI] 10.1038/s41586-021-03673-2 PMC 바로가기 [Article Type] Article
Bioinformatics Analysis of Spike Proteins of Porcine Enteric CoronavirusesResearch Article Published on 2021-07-012022-10-27 Journal: BioMed Research International [Category] Coronavirus, [키워드] acute diarrhea Analysis analyzed antiviral drugs bioinformatics biological function coronavirus coronavirus spike protein Coronaviruses domain domains enteric epidemic diarrhea epitope Epitopes functional gastroenteritis glycosylation heptad repeat hydrophilicity hydrophobicity motif motifs PEDV Phosphorylation phosphorylation sites physical Porcine deltacoronavirus predicted profiles Protein S protein S2 subunit signal peptide spike syndrome TGEV transmembrane region virus [DOI] 10.1155/2021/6689471 PMC 바로가기 [Article Type] Research Article
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infectionmRNA-1273 백신 접종에 의해 유도된 항체는 SARS-CoV-2 감염에서보다 수용체 결합 도메인에 더 광범위하게 결합합니다Research Article Published on 2021-06-302022-09-10 Journal: Science Translational Medicine [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immunity affected antibodies antibody antibody epitope antibody epitopes antibody immunity Antibody Response Antibody responses antigenic evolution binding breadth characterized convalescent sera coronavirus deep demonstrated dose elicited epitope Epitopes erosion greater human antibody response Immunity immunization Infection less Moderna mRNA-1273 vaccine mRNA mRNA-1273 mRNA-1273 COVID-19 vaccine Mutation natural infection neutralization Neutralizing activity Neutralizing antibodies neutralizing antibody polyclonal antibodies polyclonal antibody raised RBD RBD mutation RBD-binding antibody Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 evolution SARS-COV-2 infection SARS-CoV-2 spike protein sera severe acute respiratory syndrome Coronavirus specificity Spike protein susceptibility the antibody response the RBD the receptor-binding domain the SARS-CoV-2 vaccination Vaccine variant variants Viral viral evolution viral mutation Viral mutations [DOI] 10.1126/scitranslmed.abi9915 PMC 바로가기 [Article Type] Research Article
Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2ORF10 단백질의 주목할만한 서열 상동성은 SARS-CoV-2의 구조를 내부 조사합니다Article Published on 2021-06-302022-09-11 Journal: International journal of biological macromolecules [Category] Coronavirus, MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome Amino acid amino acids Analysis antigenicity carried caused change clone coil convalescent patient Convalescent patients coronavirus coronavirus disease COVID-19 CTL cytotoxic T lymphocyte decrease epitope Epitopes expressed Fatality rate homology in silico in vivo Intrinsic disorder lymphocyte MERS Missense mutation Missense mutations Mutation mutations nine Open reading frame ORF10 ORF10 protein pandemic pangolin pangolin-CoV Pangolin-CoV-2020 Pathogenesis pathogenesis of COVID-19 pathology physicochemical predicted Protein Proteins reactive respiratory SARS-CoV SARS-CoV-2 sequence sequence homology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 shift similarity solubility stability strand T cell tyrosine unique variant [DOI] 10.1016/j.ijbiomac.2021.03.199 PMC 바로가기 [Article Type] Article
Use of Lateral Flow Immunoassay to Characterize SARS-CoV-2 RBD-Specific Antibodies and Their Ability to React with the UK, SA and BR P.1 Variant RBDsCommunication Published on 2021-06-302022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Ability ACE2 acute respiratory syndrome African anti-SARS-CoV-2 anti-spike antibody antibody Antibody neutralization binding activity characterized circulating variants coronavirus COVID-19 demonstrated diagnostic dominant E484K effective epitope epitope binning epitope bins escaped Flow humoral identifying implication induce Infection Lateral lateral flow immunoassay Lateral flow immunoassays Mutation N501Y neutralization neutralization activity Neutralizing activity neutralizing antibody not neutralize P.1 rapid neutralization test RBD RBDs Receptor binding domain receptor binding domain (RBD) retained SARS-CoV-2 SARS-CoV-2 variant Seven South Spike protein therapeutic therapeutic antibody cocktail variant variants [DOI] 10.3390/diagnostics11071190 PMC 바로가기 [Article Type] Communication
Up State of the SARS-COV-2 Spike Homotrimer Favors an Increased Virulence for New VariantsMedical Technology Published on 2021-06-302022-11-01 Journal: Frontiers in Medical Technology [Category] COVID-19, [키워드] ACE2 alteration Analysis Angiotensin-converting enzyme antibody production B-cell B.1.351 binding affinity carried cellular receptor Combination conformational state conformational states contribute coronavirus COVID-19 pandemic disease dose Efficiency electrostatic interactions epitope Epitopes explain Hospitalization Increased Infection Interaction mapped molecular mechanism Mutation mutations New protein–protein interactions raising RBD RBD-ACE2 released responsible S trimer SARS-CoV-2 South spike Spread stability state Structure the receptor-binding domain the SARS-CoV-2 the vaccine Therapeutic molecule therapeutic option Transmissibility trimeric variant variants variants of SARS-CoV-2 virulence virulent virus wild type [DOI] 10.3389/fmedt.2021.694347 PMC 바로가기 [Article Type] Medical Technology
Diverse Humoral Immune Responses in Younger and Older Adult COVID-19 PatientsResearch Article Published on 2021-06-292022-10-29 Journal: mBio [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome age Amino acid antibody antibody reactivity Antibody Response antigenic B.1.1.7 B.1.526 B1.351 CD40 ligand chemokine clinical outcomes Clinical severity clinical variables Cohort collected coronavirus Coronaviruses correlation COVID-19 cytokine Cytokine analysis EGF elevated Endemic Endemic coronaviruses epidermal epitope Epitopes Frame group growth factor HCoV-NL63 HCoV-OC43 human coronavirus OC43 Humoral immunity IgG antibody IL-10 IL-15 in vitro transcription individual interferon IP-10 mechanically ventilated membrane MERS-CoV Microarray Middle East Mutation nucleocapsid Older Older age older patient ORF overlap overlapping P.1 Patient patients probe profiles Protein Proteins Region respiratory syndrome coronavirus response SARS-CoV SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 spike SARS-CoV-2 variant selected serum sample significantly significantly higher subset systemic cytokine the N protein the S1 protein translation Ventilated Viral variants [DOI] 10.1128/mBio.01229-21 PMC 바로가기 [Article Type] Research Article
A newly identified linear epitope on non-RBD region of SARS-CoV-2 spike protein improves the serological detection rate of COVID-19 patientsSARS-COV-2 스파이크 단백질의 비 RBD 영역에서 새로 확인 된 선형 에피토프는 COVID-19 환자의 혈청 학적 검출 속도를 향상시킵니다.Research Published on 2021-06-262022-09-01 Journal: BMC Microbiology [Category] MERS, 진단, 치료기술, [키워드] addition analyzed antibody Antigen asymptomatic infection asymptomatic infections asymptomatic patients B cell B cell linear epitopes Combination convalescent sera convalescent serum convenience correlation COVID-19 patient detect detection rate ELISA epitope epitope peptide Epitopes exhibited fast feasibility highest Humoral immunity identify IMPROVE Infectious disease Infectious diseases information lack linear linear epitopes lowest medium neutralizing antibody overlapping Patient peptide peptide-based peptides positive positive correlation positive rate Protein reaction rate reactivity reported Research Result S protein SARS-CoV-2 SARS-CoV-2 spike protein serological serological data serum samples significantly Spike protein subsequent supplementary material Support the S protein titre total patient total patients with COVID-19 [DOI] 10.1186/s12866-021-02241-y PMC 바로가기 [Article Type] Research
Multi-Subunit SARS-CoV-2 Vaccine Design Using Evolutionarily Conserved T- and B- Cell EpitopesArticle Published on 2021-06-262022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] adverse effects Analysis B cell epitope bioinformatics candidate conserved Critical cross-protection docking result elicit envelope protein epitope form human coronavirus human coronaviruses identify IgG IgM Immune simulation in viral indicate membrane MERS mutate nucleocapsid offer performed predicted public health crisis risk SARS-CoV SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 variants sequence sequence similarity Seven stable complex T cell responses the vaccine toll-like receptor 4 Toxicity unlikely Vaccine vaccine construct Vaccine design variant variants viral replication virus [DOI] 10.3390/vaccines9070702 PMC 바로가기 [Article Type] Article