A Vimentin-Targeting Oral Compound with Host-Directed Antiviral and Anti-Inflammatory Actions Addresses Multiple Features of COVID-19 and Related Diseases숙주 지향적 항바이러스 및 항염 작용이 있는 Vimentin 표적 경구 화합물은 COVID-19 및 관련 질병의 여러 특징을 다룹니다Research Article Published on 2021-10-122022-09-10 Journal: mBio [Category] MERS, 변종, 치료제, [키워드] Action affected Anti-inflammation anti-inflammatory actions Antiviral Bleomycin cellular cellular processe complications Compound COVID-19 cultured cells damage disease symptom Diseases drug effective Efficacy endosomal trafficking Factor fibrosis filaments focus function host immune responses host-directed antiviral human ACE2 hyperinflammation identify immune responses Infection inhibited late-stage disease lung damage Lung injury macrophages mechanism mice Multiple oral outcome overactive pathogen pathogen clearance Patient physical physical properties Protein RATs reduced reducing regulatory T cells Safe SARS-COV-2 infection SARS-CoV-2 spike protein SARS-CoV-2 virus small molecule Spike protein T cells targets the SARS-CoV-2 the SARS-CoV-2 virus therapeutic agent therapeutic agents therapeutic potential treating COVID-19 triggered unique vimentin Viral Viral load Viral mutations [DOI] 10.1128/mBio.02542-21 PMC 바로가기 [Article Type] Research Article
Obesity Correlates With Pronounced Aberrant Innate Immune Responses in Hospitalized Aged COVID-19 Patients비만은 입원한 노인 COVID-19 환자의 비정상적인 선천성 면역 반응과 관련이 있습니다Comparative Study Published on 2021-10-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response Admission Admissions advanced age age aging Antibody titers BMI caused changes in Chronic low-grade inflammation circulating Concentration coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 cytokine cytokine response Cytokines death defined dysregulated elevated Frequency hospitalizations hospitalized COVID-19 patient hospitalized COVID-19 patients host response IgG antibody IgG antibody titers immune Immune cell immune cells immune responses individual Infection Inflammatory cytokine inflammatory cytokine production Innate Innate immunity innate response intensive care intensive care unit mediators mitogen monocyte Monocytes obesity occur patients Prevalence respiratory response responsible risk risk factor Risk factors SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe coronavirus disease severe disease significant negative correlation subset These data [DOI] 10.3389/fimmu.2021.760288 PMC 바로가기 [Article Type] Comparative Study
Comparison of antibody and T cell responses elicited by BBIBP-CorV (Sinopharm) and BNT162b2 (Pfizer-BioNTech) vaccines against SARS-CoV-2 in healthy adult humans건강한 성인에서 SARS-CoV-2에 대한 BBIBP-CorV(Sinopharm) 및 BNT162b2(Pfizer-BioNTech) 백신에 의해 유도된 항체 및 T 세포 반응의 비교Original Article Published on 2021-10-112022-09-11 Journal: GeroScience [Category] MERS, SARS, 치료법, [키워드] adaptive Adaptive immunity Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies Anti-spike antibody BBIBP-CorV BNT162b2 cell-mediated immune response Cell-mediated immune responses Convalescent patients cumulative domain effective elicit elicited epitope Epitopes evaluate healthy healthy individuals Human humoral IFNγ ELISpot assay IFNγ-producing T cells IFNγ IgA antibodies IgA antibody IgG immune response immune responses Immunity immunologically in healthy individuals inactivated injected investigated Live virus membrane mRNA mRNA vaccine mRNA-based much lower nucleocapsid participant pattern Pfizer-BioNTech Protein Proteins Quantitative RBD S protein epitopes SARS-CoV-2 SARS-CoV-2 virus Sinopharm supplementary material T cell T cell response target the S protein These data vaccination Vaccine virus Volunteer [DOI] 10.1007/s11357-021-00471-6 PMC 바로가기 [Article Type] Original Article
The development of biologics to target SARS-CoV2: Treatment potential of antibodies in patient groups with poor immune responseCOVID-19 therapy Published on 2021-10-092022-10-31 Journal: Current Research in Pharmacology and Drug Discovery [Category] COVID-19, [키워드] anti-SARS-CoV-2 antibodies antibody Biologic drugs cancer patient Clinical outcome convalescent plasma COVID-19 Cytokine release syndrome development disease effective Evidence Hematologic malignancy immune response immune responses immunodeficiency Immunosuppression Impaired immunity include Infection monoclonal monoclonal antibody Neutralizing novel SARS-CoV-2 virus Patient patient group patients performed populations Primary outcome receiving repurposing SARS-CoV-2 SARS-COV-2 infection severe disease Severe infection severe SARS-CoV-2 solid organ transplant SOT SOT patient SOT patients Spike protein subgroup subpopulation subsequent therapy Treatment underlying disease variant [DOI] 10.1016/j.crphar.2021.100064 PMC 바로가기 [Article Type] COVID-19 therapy
A Serological Snapshot of COVID-19 Initial Stages in Israel by a 6-Plex Antigen Array6-플렉스 항원 어레이에 의한 이스라엘의 COVID-19 초기 단계의 혈청학적 스냅샷Research Article Published on 2021-10-062022-09-10 Journal: Microbiology Spectrum [Category] MERS, SARS, 진단, 치료법, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody Antigen applied characterization collected COVID-19 COVID-19 outbreak COVID-19 pandemic COVID-19 patient COVID-19 patients cross-reacting antibodies death ectodomain evaluate FIVE generate healthy healthy subject IgA antibodies IgA antibody IgG IgM immune response immune responses inactivated individual individuals Israel Microarray Microarrays multiplex naïve individuals nonspecific NTD nucleocapsid outbreak pandemic Patient patients PCR presenting Protein qRT-PCR quantitative PCR RBD resulting reverse transcription SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 seroprevalence SARS-CoV-2-specific IgG screened sensitivity sera Seroconversion serological serological marker serology Specific specific IgM specificity spike Stage subunit symptom onset symptomatic trials Vaccine Viral Viral antigen viral antigens virus was used [DOI] 10.1128/Spectrum.00870-21 PMC 바로가기 [Article Type] Research Article
Impaired function and delayed regeneration of dendritic cells in COVID-19코로나19에서 손상된 수지상 세포의 기능 장애 및 재생 지연Clinical Trial Published on 2021-10-062022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 바이오마커, 임상, [키워드] accompanied activated acute illness acute phase adaptive Adaptive immune response adaptive immune responses alteration analyzed antibody antibody-secreting cells antiviral immunity Blood CD14 CD14+ cell CD14+ cells CD163 CD4 CD86 Cell cells circulating classical monocyte classical monocytes Clinical management consequence contribute correlated COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity DCs dendritic cell dendritic cells Depletion disease disease severity downregulation dysregulated dysregulated innate immune response expansion follicular Frequency functional healthy controls helper cells HLADR hospitalized COVID-19 patient Host immune response identify immune responses immunopathology Impaired impairment Increased Inflammatory response Inflammatory responses inhibitory innate immune response long-lasting manifestation Mild modulation monocyte monocyte subsets Monocytes naïve Patient PD-L1 persistent recognize reduced reduction regeneration SARS-COV-2 infection Secondary infection secondary infections severe disease stimulate subpopulation subset susceptibility systemic inflammation T cell T cells T follicular helper cells the disease therapy these cell These cells Trigger upregulation Viral viral infection viral infections [DOI] 10.1371/journal.ppat.1009742 PMC 바로가기 [Article Type] Clinical Trial
Tryptophan-Kynurenine Pathway in COVID-19-Dependent Musculoskeletal Pathology: A MinireviewReview Article Published on 2021-10-052022-10-31 Journal: Mediators of Inflammation [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome affecting cause coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Effect immune responses Inflammation Kynurenine pathway Lungs metabolism Musculoskeletal organ systems pathway reported respiratory tract SARS-CoV-2 System biology [DOI] 10.1155/2021/2911578 PMC 바로가기 [Article Type] Review Article
HIV status alters disease severity and immune cell responses in Beta variant SARS-CoV-2 infection waveHIV 상태는 베타 변이형 SARS-CoV-2 감염 파동에서 질병 중증도와 면역 세포 반응을 변경합니다Research Article Published on 2021-10-052022-09-10 Journal: eLife [Category] MERS, SARS, 변종, [키워드] Alter analyzed Antiretroviral therapy Beta Beta variant CD4 CD4 count CD4 counts change COVID-19 disease severity Effect had more HIV HIV infection HIV-negative Immune cell immune cell response immune responses Infection Interaction lymphocyte modulation neutrophil NLR outcomes oxygen participant Participants PLWH requiring supplemental oxygen SARS-CoV-2 SARS-CoV-2 clearance SARS-COV-2 infection SARS-CoV-2 variant second wave severity South Africa supplemental oxygen T cell the SARS-CoV-2 variant virus Wave with HIV [DOI] 10.7554/eLife.67397 PMC 바로가기 [Article Type] Research Article
Role of Extracellular Vesicles in Cell Death and Inflammation세포 사멸 및 염증에서 세포외 소포의 역할Review Published on 2021-10-052022-09-11 Journal: Cells [Category] MERS, SARS, 바이오마커, 진단, [키워드] apoptotic bodies apoptotic extracellular vesicles Cell cell death conditions death effector EVs Exosomes extracellular vesicle Extracellular vesicles focus immune immune response immune responses Infection Inflammation Intercellular communication leads Lung inflammation lung inflammatory disorders mediators Microvesicles modulating pathology pathophysiological role SARS-CoV-2 Sepsis tissue damage upregulation Vesicle [DOI] 10.3390/cells10102663 PMC 바로가기 [Article Type] Review
Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19중요한 COVID-19에서 항체 및 보체 의존성 폐렴 손상과 관련된 향상된 호산구 매개 염증Article Published on 2021-10-052022-09-11 Journal: Cell Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] Activation adaptive immune responses addition airway airways antibody Antibody Response biopsy complement Complement activation complexes coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients Critical critical COVID-19 patients Critical disease disease pathogenesis driver enhanced eosinophil evidenced Fcγ receptor FcγR hallmark immune immune complex Immune complexes immune responses Inflammation innate immune responses lung lung biopsies mechanism membrane myeloid cell myeloid cells pandemic Pathogenesis Pneumonia receptor respiratory respiratory specimen respiratory specimens SARS-CoV-2 SARS-COV-2 infection Signaling subsequent T helper vasculature Viral Viral pneumonia [DOI] 10.1016/j.celrep.2021.109798 PMC 바로가기 [Article Type] Article