Insights into the Use of C-Reactive Protein as a Diagnostic Index of Disease Severity in COVID-19 InfectionsPerspective Piece Published on 2020-08-252022-10-28 Journal: The American Journal of Tropical Medicine and Hygi [Category] COVID-19, MERS, SARS, [키워드] acute phase Anti-inflammatory Blood level C-reactive protein coagulation dysfunction complications COVID-19 COVID-19 patients CRP CRP level Cytokine storm develop disease severity elevated help hyperinflammation index infected with SARS-CoV-2 insight interleukin-6 Interpretation isoform MONITOR multiple organ failure pathology Patient patients with COVID-19 poor prognosis potentially life-threatening released Septic shock survival therapeutic option tissue damage with COVID-19 [DOI] 10.4269/ajtmh.20-0473 PMC 바로가기 [Article Type] Perspective Piece
Case Report: Canakinumab for the Treatment of a Patient With COVID-19 Acute Respiratory Distress SyndromeImmunology Published on 2020-08-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress acute respiratory distress syndrome Adaptive immune response bacterial superinfection canakinumab CD56 Cell compassionate use condition correlated COVID-19 cytokine cytokine levels Cytokine release syndrome Cytokine storm died expressing high risk hospital Hospitalization IL-1 IL-1β IL-6 IL-6 level immune cells Infection interleukin-6 Intubated Lung inflammation Lymphocyte count male monoclonal antibody Multiorgan natural killer NK cell Patient presenting reduced renal rescued respiratory SAR-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity severe cases significantly subset syndrome Treatment with COVID-19 [DOI] 10.3389/fimmu.2020.01942 PMC 바로가기 [Article Type] Immunology
High levels of serum interleukin-6 increase mortality of hepatitis B virus-associated acute-on-chronic liver failureArticle Published on 2020-08-142023-06-12 Journal: World journal of gastroenterology [Category] B형 간염, [키워드] Hepatitis B virus interleukin-6 liver failure Prognosis [DOI] 10.3748/wjg.v26.i30.4479 PMC 바로가기
COVID-19: age, Interleukin-6, C-reactive protein, and lymphocytes as key clues from a multicentre retrospective studyResearch Published on 2020-08-142022-10-30 Journal: Immunity & Ageing : I & A [Category] COVID-19, [키워드] ACE2 adaptive age analysed angiotensin-converting enzyme inhibitor Asia average blocker C-reactive protein carried CD19 CD4 CD8 Clinical course cohorts Comorbidities country Course COVID-19 COVID-19 pandemic COVID-19 severity decrease Deleterious diabetes disease dyslipidaemia effectors enzyme European evidenced Fatality rate feature form health authorities hospitalized patient hypertension hypertensive patient immune system Immunity immunological immunosenescence inhibitor innate response interleukin 6 interleukin-6 Laboratory Local lymphocyte Lymphocyte count Lymphocytes male males Mild moderate multicentre natural killer Older outcome Patient Prognosis protective effect public health ranged receptor renin-angiotensin system reported Result Retrospective study risk factor SARS-COV-2 infection severe acute respiratory syndrome coronavirus 2 severity significantly lower Spain Spanish spread to subpopulation the disease was performed [DOI] 10.1186/s12979-020-00194-w PMC 바로가기 [Article Type] Research
Targeting Endothelial Dysfunction in Eight Extreme-Critically Ill Patients with COVID-19 Using the Anti-Adrenomedullin Antibody Adrecizumab (HAM8101)Article Published on 2020-08-112022-10-28 Journal: Biomolecules [Category] COVID-19, MERS, [키워드] acute renal failure acute respiratory distress Administered administration Adrecizumab adrenomedullin antibody approach ARDS C-reactive protein calculated capillary leakage case sery coronavirus disease COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill died discharged Efficacy eight endothelial function Endothelium expected FIVE Follow-up HAM 8101 High-dose highest humanized ICU Ill inflammatory parameter intensive care interleukin-6 life-threatening low-dose mechanical ventilation median monoclonal Mortality outcome paO2/fiO2 Patient patients procalcitonin ranged renal replacement therapy resource risk Sepsis Seven severity Shock single dose small sample size SOFA SOFA score suffered surviving patient syndrome targeting the disease the patient therapeutic Vascular with COVID-19 [DOI] 10.3390/biom10081171 PMC 바로가기 [Article Type] Article
Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection A case report4900 Published on 2020-08-072022-10-30 Journal: Medicine [Category] COVID-19, MERS, [키워드] Activation acute respiratory syndrome anti-SARS-CoV-2 Case report characterized clinical complications coronavirus coronavirus disease criteria cytokine profile develop Diagnosis diagnosis of SARS-CoV-2 empiric antibiotic Follow-up Hydroxychloroquine hyper-inflammation Immunoglobulin immunoglobulin A independent Infection interleukin-6 life-threatening macrophages Multiorgan dysfunction Nasopharyngeal swab Patient polymerase chain positive reverse transcription SARS-CoV-2 SARS-COV-2 infection serum syndrome the patient tissue injury treated unique [DOI] 10.1097/MD.0000000000021570 PMC 바로가기 [Article Type] 4900
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patientsReport Published on 2020-08-072022-10-06 Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단, [키워드] Analysis Antiviral antiviral immunity bacterial superinfections Blood cause characterized Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient deficiency dendritic cell Disease progression disease severity driven by driving elicit engage ENhance epithelial exacerbated expressed expression functions hallmark host immune responses IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs immune Immune cell immunopathology Impaired increase Inflammatory response influenza infection inhibiting interfere interferon interleukin-6 ISGs Local lung lung epithelium Major mice morbidity mucosal surface Necrosis nuclear p53 parameter patients performed Peripheral blood phenotype proinflammatory proliferation respiratory viral infections response responses Science secreted severe COVID-19 severe COVID-19 patient severity Signaling susceptibility therapeutic therapeutic approaches thought Transcription transcriptional Trigger turn Type type I Type I IFN type I interferon Type III IFN viral infections Viral load viral respiratory disease viral respiratory infections Viral RNA [DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report
Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine stormArticle Published on 2020-08-062022-10-04 Journal: Nature Communications [Category] MERS, 임상, 치료법, 치료제, [키워드] Acute inflammation addition Analysis Antimicrobial responses antiviral immune responses attenuate CD8 cell population cellular cellular and molecular Computational biology and bioinformatics contribute COVID-19 COVID-19 patient COVID-19 patients Cytokine storm Cytokine storms dataset distribution excessive inflammatory response humoral identify IL-6 Immune cell immune cells immune profiling immunosuppressive drug infected with SARS-CoV-2 Inflammation Inflammatory cytokine Inflammatory response interleukin-6 monocyte Monocytes and macrophages Patient plasma B cell provide receptor reveal robust severe COVID-19 patient single-cell single-cell analysis Single-cell RNA sequencing Stage subpopulation T cells therapeutic effect Tocilizumab treat Treatment [DOI] 10.1038/s41467-020-17834-w PMC 바로가기 [Article Type] Article
SARS-CoV-2 – a new challenge for laboratory medicineReview Published on 2020-08-052022-10-27 Journal: Biochemia Medica [Category] COVID-19, [키워드] addition Biomarker Biomarkers biomarkers of inflammation C-reactive protein cause chronic disease complete blood count Corona coronavirus disease COVID-19 D-dimer develop diagnostic disease Disease progression evaluate fibrinogen immune system include individual Inflammation interleukin-6 Laboratory Laboratory medicine myocardial damage N-terminal patient safety peptide Predictive procalcitonin Prothrombin time respiratory SARS-CoV-2 sensitivity shown specific biomarker specificity subject subjects tested Vascular virus [DOI] 10.11613/BM.2020.030503 PMC 바로가기 [Article Type] Review
SARS-CoV-2 – a new challenge for laboratory medicineReview Published on 2020-08-052022-10-27 Journal: Biochemia Medica [Category] Coronavirus, COVID-19, MERS, SARS, [키워드] addition Biomarker Biomarkers biomarkers of inflammation C-reactive protein cause chronic disease complete blood count Corona coronavirus disease COVID-19 D-dimer develop diagnostic disease Disease progression evaluate fibrinogen immune system include individual Inflammation interleukin-6 Laboratory Laboratory medicine myocardial damage N-terminal patient safety peptide Predictive procalcitonin Prothrombin time respiratory SARS-CoV-2 sensitivity shown specific biomarker specificity subject subjects tested Vascular virus [DOI] 10.11613/BM.2020.030503 PMC 바로가기 [Article Type] Review