pandemic – Page 51 – Communicable Diseases Research

Emergence and Spread of the SARS-CoV-2 Variant of Concern Delta across Different Brazilian Regions

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 치료기술,

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation

Article

Published on 2022-10-262022-11-15
Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제,

[키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24
[DOI] 10.1128/mbio.02543-22 PMC 바로가기

SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants viral evolution virulence virus with COVID-19
[DOI] 10.1128/spectrum.01604-22 PMC 바로가기

Concordance of SARS-CoV-2 Antibody Results during a Period of Low Prevalence

Article

Published on 2022-10-262022-11-15
Journal: mSphere [Category] COVID19(2023년), SARS, 진단,

[키워드] 95% confidence interval Abbott acute respiratory syndrome Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG Antigen antigens Architect assays CDC collected combinations Concentration Concordance contributed coronavirus coronavirus disease COVID-19 Elecsy ELISA enzyme-linked immunosorbent evaluate False positivity first test Frequency IgG IgG antibodies immunoassay immunoassays Immunoglobulin individual investigated low prevalence nucleocapsid nucleocapsid protein pandemic participant Participants performed Period positive positive result Prevalence produced proportion quantified Research Result Roche SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG SARS-CoV-2 IgG antibody sequential test sera serological test seropositive specimen Spike protein subset Support target tested the SARS-CoV-2 The United States Vaccine vaccine availability
[DOI] 10.1128/msphere.00257-22 PMC 바로가기

Infection with SARS-CoV-2 is associated with menstrual irregularities among women of reproductive age

Article

Published on 2022-10-262022-11-15
Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술,

Building a Resilient Scientific Network for COVID-19 and Beyond

Article

Published on 2022-10-262022-11-15
Journal: mBio [Category] COVID19(2023년), SARS, 변종, 진단,

Association of Results of Four Lateral Flow Antibody Tests with Subsequent SARS-CoV-2 Infection

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술,

[키워드] 95% confidence interval acute respiratory syndrome adjusted anti-SARS-CoV-2 IgG antibody assist association baseline Cohort cohort study conducted coronavirus Coverage COVID COVID-19 demonstrated disease risk England fire Flow Follow-up hospital IgG Immunity immunoassay immunoassays incidence rate individual Infection investigated Laboratory laboratory assays Lateral Lateral flow device lateral flow device. lateral flow immunoassay Lateral flow test LFIA LFIAs management microbiologically natural infection pandemic participant point-of-care test Poisson regression model Police service Population screening positive predicted prospective cohort study Protective Rapid Rapid test rapid test cassette recruitment Research Result risk risk factor Roche SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 IgG SARS-COV-2 infection specificity subsequent Surescreen susceptibility symptomatic SARS-CoV-2 infection Test threshold United Kingdom unvaccinated populations Vaccine was tested
[DOI] 10.1128/spectrum.02468-22 PMC 바로가기

Monitoring SARS-CoV-2 Infection Using a Double Reporter-Expressing Virus

Article

Published on 2022-10-262022-11-15
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료제,

[키워드] acute respiratory syndrome animal models antiviral therapeutics antivirals biology of SARS-CoV-2 Care caused comparable contagious coronavirus coronavirus disease COVID-19 cultured cells demonstrated detect Express expresse expressing expression level facilitate feasibility fluorescent Genes hACE2 hamster Health human Angiotensin-converting enzyme in vitro In vitro assay in vivo infected cell Infection K18 knowledge limitation luciferase luciferase reporter gene luciferase reporter genes mCherry monitoring neutralizing antibody overcome pandemic pathogenicity Protein recombinant reporter responsible robust SARS-CoV-2 SARS-CoV-2 biology SARS-COV-2 infection transgenic mice Transmission Vaccine viral fitness viral infection virus wild-type
[DOI] 10.1128/spectrum.02379-22 PMC 바로가기

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Article

Published on 2022-10-262022-11-15
Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC
[DOI] 10.1128/jvi.01162-22 PMC 바로가기

The New SARS-CoV-2 Variants and Their Epidemiological Impact in Mexico

Article

Published on 2022-10-262022-11-16
Journal: mBio [Category] COVID19(2023년), SARS, 변종,