The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva인간 혈장 및 타액에서 Molnupiravir 및 대사 산물 β-d-N4-hydroxycytidine의 동시 정량을 위한 새로운 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-09-102022-09-10 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, SARS, 비임상, 치료기술, [키워드] Accuracy Acetate acetonitrile Ammonium Ammonium acetate analyte antiviral therapy caused clinical column concentrations conducted coronavirus Coronaviruses COVID-19 COVID-19 infection EIDD-2801 followed by global pandemic highly pathogenic Human plasma Infection Influenza LC-MS/MS linear m/z metabolite molnupiravir MPV N4-hydroxycytidine NHC Patient patients with COVID-19 pharmacokinetic plasma polar Precision protein precipitation quantification Saliva SRM Treatment validation was performed water [DOI] 10.1016/j.jpba.2021.114356 PMC 바로가기 [Article Type] Article
Sensitivity of Rapid Antigen Testing and RT-PCR Performed on Nasopharyngeal Swabs versus Saliva Samples in COVID-19 Hospitalized Patients: Results of a Prospective Comparative Trial (RESTART)Article Published on 2021-09-092022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen applied approach assays Basel biosensor collected Comparative conducted COVID-19 COVID-19 diagnosis Diagnosis diagnostic duration of symptom exhibited help Hospitalized hospitalized patient hospitalized patients intensive care investigated IQR mitigate much lower nasopharyngeal Nasopharyngeal swab Non-invasive Patient Prospective prospective observational study Rapid rapid antigen test rapid antigen testing RAT RATs Result RT-PCR RT-PCR testing Saliva salivary Sample SARS-CoV-2 SARS-CoV-2 diagnosis sensitivity shortage of reagent specificity specimen Standard Q step Swab swabs Switzerland Test Testing the median Viral transport medium VTM was used [DOI] 10.3390/microorganisms9091910 PMC 바로가기 [Article Type] Article
Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challengesReviews Published on 2021-09-072022-10-28 Journal: Applied Physics Reviews [Category] COVID-19, [키워드] acute respiratory syndrome approach asymptotic common Concentration contagious coronavirus COVID-19 COVID-19 pandemic detect Diagnosis diagnostic drastic effective examined include Influenza investigated measure MERS Middle East nasal noninvasive opportunity optical pandemic platform POC point-of-care reduce Saliva SARS-CoV-2 SARS-CoV-2 spike protein sensitivity serological samples Spread Symptom management syndrome Urine vaccination viral infection Viral load virion [DOI] 10.1063/5.0022211 PMC 바로가기 [Article Type] Reviews
The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemicRandomized Controlled Trial Published on 2021-09-072022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] 6-lead ECG Accuracy adverse event approach approval cause clinical clinical trial Community concern COVID-19 COVID-19 disease COVID-19 infection COVID-19 pandemic determine develop diagnostic diagnostic tests ECG effective Efficacy eligible enrolled enrolment ethical committee exclusion exclusion criteria flexibility group groups HCQ health system Healthcare systems Hydroxychloroquine Inclusion individual infection control infection rate Internet lack measure medication methodology number observation Open-label organism outbreak pandemic PCR physical contact Population prevention of COVID-19 Prophylaxis Prospective clinical trial protocol Randomized recruitment Remote ECG monitoring remote monitoring Research researcher resource respond Result RNA Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Spread strained Treatment Trial Trial management USA World Health Organization [DOI] 10.1186/s13063-021-05537-6 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sample collection and transport strategies to enhance yield, accessibility, and biosafety of COVID-19 RT-PCR testingEditor's Choice Published on 2021-09-062022-10-29 Journal: Journal of Medical Microbiology [Category] COVID-19, SARS, [키워드] biosafety buffer collected combined use COVID-19 COVID-19 testing diagnostic diagnostics Direct eNAT ENhance evaluate Gap inactivation nasal nasal swab nasal swabs nasopharyngeal Non-invasive NP swab oral oral swab oral swabs patients point-of-care polymerase chain positive Result RT-PCR RT-PCR testing Safe Saliva sample collection SARS-CoV-2 sensitivity significantly more specimen Swab swabs Transport viral transport media VTM widespread [DOI] 10.1099/jmm.0.001380 PMC 바로가기 [Article Type] Editor's Choice
Saliva-Based ELISAs for Effective SARS-CoV-2 Antibody Monitoring in Vaccinated Individuals예방접종을 받은 개인의 효과적인 SARS-CoV-2 항체 모니터링을 위한 타액 기반 ELISAReview Published on 2021-09-032022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody detection coronavirus disease Coronavirus disease 2019 COVID-19 develop diagnostic Efficacy ELISA ELISAs enzyme Health Health Organization immune response Immunity immunology immunosorbent implementation individual monitoring pandemic persistence Re-infection reported researcher Saliva saliva-based antibody detection SARS-CoV-2 SARS-COV-2 infection Serological testing sustained Vaccine vaccine efficacy Vaccines virus WHO widespread World Health Organization [DOI] 10.3389/fimmu.2021.701411 PMC 바로가기 [Article Type] Review
Detection of SARS-CoV-2 virus using an alternative molecular method and evaluation of biochemical, hematological, inflammatory, and oxidative stress in healthcare professionals대체 분자 방법을 사용한 SARS-CoV-2 바이러스 검출 및 의료 전문가의 생화학적, 혈액학적, 염증성 및 산화적 스트레스 평가Article Published on 2021-09-012022-09-11 Journal: Microbial pathogenesis [Category] SARS, 치료기술, [키워드] Alanine alanine aminotransferase ALT aspartate Aspartate aminotransferase AST biochemical both groups Brazil C-reactive protein caused changes in China cholesterol city condition coronavirus coronavirus disease Coronavirus disease 2019 corpuscular cortisol damage detection detrimental diagnosed elevated eosinophil eosinophils evaluated group HDL Health Health Organization Health professionals Healthcare professional hematocrit hematological hemoglobin immunochromatographic test individual Inflammation Inflammatory inflammatory activity inflammatory changes International lactic lactic dehydrogenase LDH leukocytes Lymphocytes marker mean corpuscular volume mental health molecular Monocytes mucoprotein Neutrophils new strain new strain of coronavirus occurred outbreak oxidative damage oxidative stress Participants percentage percentages physical plasma Platelet Platelets professional professionals public health emergency qRT-PCR reduced RT-LAMP RT-PCR Saliva saliva samples salivary SARS-CoV-2 SARS-CoV-2 virus significant increase significantly Stress stressful situation study population the SARS-CoV-2 virus Triglyceride triglycerides uninfected uric acid Volume were infected WHO World Health Organization Wuhan [DOI] 10.1016/j.micpath.2021.104975 PMC 바로가기 [Article Type] Article
Validation and implementation of a direct RT-qPCR method for rapid screening of SARS-CoV-2 infection by using non-invasive saliva samples비침습적 타액 샘플을 사용하여 SARS-CoV-2 감염의 신속한 스크리닝을 위한 직접 RT-qPCR 방법의 검증 및 구현Article Published on 2021-09-012022-09-11 Journal: International Journal of Infectious Diseases [Category] SARS, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Asymptomatic Barcelona comparable conducted coronavirus COVID-19 diagnostic diagnostic sensitivity Direct health worker hospital implementation less nasopharyngeal specimen Non-invasive participant PCR Phase 1 Phase 2 Phase 3 pilot screening positive positive result processed RNA RNA extraction RT-qPCR Saliva saliva samples SARS-CoV-2 SARS-COV-2 infection scaled up Screening screening method Sensitivity and specificity severe acute respiratory syndrome Coronavirus Spain supervision Surveillance validation virus inactivation [DOI] 10.1016/j.ijid.2021.07.054 PMC 바로가기 [Article Type] Article
Saliva for molecular detection of SARS-CoV-2 in school-age children학령기 아동의 SARS-CoV-2 분자 검출용 타액Observational Study Published on 2021-09-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] MERS, SARS, 임상, 진단, 치료기술, [키워드] 95% CI 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age carried children Concordance coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cycle cycle threshold demonstrated determine diagnostic Diagnostic accuracy Dubai Gender Kappa coefficient male molecular nasopharyngeal Nasopharyngeal swab Negative predictive value not differ NP swab participant positive predictive values presenting provided RdRP RdRp gene recruited reported respiratory reverse transcriptase reverse transcriptase PCR RT-PCR Saliva saliva samples SARS-CoV-2 SARS-CoV-2 RT-PCR significantly higher specificity specimen Standard deviation Swab tested threshold United Arab Emirates virus detection [DOI] 10.1016/j.cmi.2021.02.009 PMC 바로가기 [Article Type] Observational Study
Frequency of putative enteric zoster diagnosed using saliva samples in patients with abdominal pain: a prospective study복통 환자에서 타액 샘플을 사용하여 진단된 가설적 장내 대상포진의 빈도: 전향적 연구Article Published on 2021-09-012023-05-31 Journal: Infectious diseases (London, England) [Category] SARS, 대상포진, 두창, 수두, 홍역, [키워드] enteric zoster Saliva Varicella-Zoster Virus [DOI] 10.1080/23744235.2021.1908593