The development and validation of a novel LC-MS/MS method for the simultaneous quantification of Molnupiravir and its metabolite ß-d-N4-hydroxycytidine in human plasma and saliva인간 혈장 및 타액에서 Molnupiravir 및 대사 산물 β-d-N4-hydroxycytidine의 동시 정량을 위한 새로운 LC-MS/MS 방법의 개발 및 검증Article Published on 2021-09-102022-09-10 Journal: Journal of pharmaceutical and biomedical analysis [Category] MERS, SARS, 비임상, 치료기술, [키워드] Accuracy Acetate acetonitrile Ammonium Ammonium acetate analyte antiviral therapy caused clinical column concentrations conducted coronavirus Coronaviruses COVID-19 COVID-19 infection EIDD-2801 followed by global pandemic highly pathogenic Human plasma Infection Influenza LC-MS/MS linear m/z metabolite molnupiravir MPV N4-hydroxycytidine NHC Patient patients with COVID-19 pharmacokinetic plasma polar Precision protein precipitation quantification Saliva SRM Treatment validation was performed water [DOI] 10.1016/j.jpba.2021.114356 PMC 바로가기 [Article Type] Article
Sensitivity of Rapid Antigen Testing and RT-PCR Performed on Nasopharyngeal Swabs versus Saliva Samples in COVID-19 Hospitalized Patients: Results of a Prospective Comparative Trial (RESTART)Article Published on 2021-09-092022-10-29 Journal: Microorganisms [Category] COVID-19, [키워드] Antigen applied approach assays Basel biosensor collected Comparative conducted COVID-19 COVID-19 diagnosis Diagnosis diagnostic duration of symptom exhibited help Hospitalized hospitalized patient hospitalized patients intensive care investigated IQR mitigate much lower nasopharyngeal Nasopharyngeal swab Non-invasive Patient Prospective prospective observational study Rapid rapid antigen test rapid antigen testing RAT RATs Result RT-PCR RT-PCR testing Saliva salivary Sample SARS-CoV-2 SARS-CoV-2 diagnosis sensitivity shortage of reagent specificity specimen Standard Q step Swab swabs Switzerland Test Testing the median Viral transport medium VTM was used [DOI] 10.3390/microorganisms9091910 PMC 바로가기 [Article Type] Article
Fast, accurate, point-of-care COVID-19 pandemic diagnosis enabled through advanced lab-on-chip optical biosensors: Opportunities and challengesReviews Published on 2021-09-072022-10-28 Journal: Applied Physics Reviews [Category] COVID-19, [키워드] acute respiratory syndrome approach asymptotic common Concentration contagious coronavirus COVID-19 COVID-19 pandemic detect Diagnosis diagnostic drastic effective examined include Influenza investigated measure MERS Middle East nasal noninvasive opportunity optical pandemic platform POC point-of-care reduce Saliva SARS-CoV-2 SARS-CoV-2 spike protein sensitivity serological samples Spread Symptom management syndrome Urine vaccination viral infection Viral load virion [DOI] 10.1063/5.0022211 PMC 바로가기 [Article Type] Reviews
The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemicRandomized Controlled Trial Published on 2021-09-072022-10-04 Journal: Trials [Category] SARS, 임상, [키워드] 6-lead ECG Accuracy adverse event approach approval cause clinical clinical trial Community concern COVID-19 COVID-19 disease COVID-19 infection COVID-19 pandemic determine develop diagnostic diagnostic tests ECG effective Efficacy eligible enrolled enrolment ethical committee exclusion exclusion criteria flexibility group groups HCQ health system Healthcare systems Hydroxychloroquine Inclusion individual infection control infection rate Internet lack measure medication methodology number observation Open-label organism outbreak pandemic PCR physical contact Population prevention of COVID-19 Prophylaxis Prospective clinical trial protocol Randomized recruitment Remote ECG monitoring remote monitoring Research researcher resource respond Result RNA Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Spread strained Treatment Trial Trial management USA World Health Organization [DOI] 10.1186/s13063-021-05537-6 PMC 바로가기 [Article Type] Randomized Controlled Trial
Sample collection and transport strategies to enhance yield, accessibility, and biosafety of COVID-19 RT-PCR testingEditor's Choice Published on 2021-09-062022-10-29 Journal: Journal of Medical Microbiology [Category] COVID-19, SARS, [키워드] biosafety buffer collected combined use COVID-19 COVID-19 testing diagnostic diagnostics Direct eNAT ENhance evaluate Gap inactivation nasal nasal swab nasal swabs nasopharyngeal Non-invasive NP swab oral oral swab oral swabs patients point-of-care polymerase chain positive Result RT-PCR RT-PCR testing Safe Saliva sample collection SARS-CoV-2 sensitivity significantly more specimen Swab swabs Transport viral transport media VTM widespread [DOI] 10.1099/jmm.0.001380 PMC 바로가기 [Article Type] Editor's Choice
Saliva-Based ELISAs for Effective SARS-CoV-2 Antibody Monitoring in Vaccinated Individuals예방접종을 받은 개인의 효과적인 SARS-CoV-2 항체 모니터링을 위한 타액 기반 ELISAReview Published on 2021-09-032022-09-11 Journal: Frontiers in Immunology [Category] SARS, 진단, 치료기술, [키워드] antibody Antibody detection coronavirus disease Coronavirus disease 2019 COVID-19 develop diagnostic Efficacy ELISA ELISAs enzyme Health Health Organization immune response Immunity immunology immunosorbent implementation individual monitoring pandemic persistence Re-infection reported researcher Saliva saliva-based antibody detection SARS-CoV-2 SARS-COV-2 infection Serological testing sustained Vaccine vaccine efficacy Vaccines virus WHO widespread World Health Organization [DOI] 10.3389/fimmu.2021.701411 PMC 바로가기 [Article Type] Review
Are saliva and deep throat sputum as reliable as common respiratory specimens for SARS-CoV-2 detection? A systematic review and meta-analysis타액과 인후 가래는 SARS-CoV-2 검출을 위한 일반적인 호흡기 표본만큼 신뢰할 수 있습니까? 체계적인 검토 및 메타 분석Review Published on 2021-09-012022-09-11 Journal: American journal of infection control [Category] SARS, 치료기술, [키워드] 95% CI 95% confidence interval Analysis Asymptomatic Asymptomatic cases asymptomatic patients Bronchoalveolar lavage fluid COVID-19 COVID-19 infection COVID-19 pandemic definitive diagnosis diagnostic diagnostic sensitivity diagnostic test diagnostic value disease severity DTS Evidence inclusion criteria Infection Laboratory Meta-analysis Mild nasopharyngeal Nasopharyngeal swab nasopharyngeal swabs oropharyngeal swab oropharyngeal swabs patients with COVID-19 performed provide Quantitative analysis raise random-effects model reliability respiratory specimen retrieved RT-PCR RT-PCR diagnostic test RT-PCR tests Saliva sampling SARS-CoV-2 SARS-CoV-2 detection SARS-COV-2 infection sensitivity Severe patient severe patients severity specimen specimens sputum Stata Stata software Support swabs symptomatic patient Symptomatic patients systematic review Systemic review the disease Viral load was performed [DOI] 10.1016/j.ajic.2021.03.008 PMC 바로가기 [Article Type] Review
Initial Evaluation of a Mobile SARS-CoV-2 RT-LAMP Testing Strategy모바일 SARS-CoV-2 RT-LAMP 테스트 전략의 초기 평가Article Published on 2021-09-012022-09-12 Journal: Journal of biomolecular techniques : JBT [Category] SARS, 진단, [키워드] acute respiratory syndrome asymptomatic individual collected colorimetric LAMP Concordance coronavirus criteria Donor evaluated false-negative rate group heat-inactivated identify individual isothermal amplification Laboratory limitations Mobile molecular Molecular biology point-of-care point-of-care test polymerase chain positive qRT-PCR qRT-PCR assay qRT-PCR assays Quantitative RT-LAMP Saliva saliva-based. SARS-CoV-2 SARS-CoV-2 RNA Strategy subsequent Surveillance tested Testing the United State Volunteer [DOI] 10.7171/jbt.21-32-03-009 PMC 바로가기 [Article Type] Article
Real-time optical analysis of a colorimetric LAMP assay for SARS-CoV-2 in saliva with a handheld instrument improves accuracy compared with endpoint assessment휴대용 기기를 사용하여 타액에서 SARS-CoV-2에 대한 비색 LAMP 분석의 실시간 광학 분석으로 종말점 평가와 비교하여 정확도 향상Article Published on 2021-09-012022-09-11 Journal: Journal of biomolecular techniques : JBT [Category] SARS, 진단, 치료기술, [키워드] Accuracy acute respiratory syndrome coronavirus Analysis approach approved bypassed change clinical sample clinical samples collected color controlling coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Course COVID-19 current detect detection system diagnostic diagnostic testing diagnostics drop drug Drug administration Endpoint FDA approval food hydrolysis IMPROVE inactivated invasive isothermal LAMP less limit of detection MONITOR Nasopharyngeal swab nasopharyngeal swabs near patient. negative sample nucleic acid nucleic acid amplification nucleotide observation optical pandemic Patient pH indicator positive processed protocol Quantitative reaction respiratory RNA RNA detection RNA extraction RT-LAMP Saliva SARS-CoV-2 SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 specimen this system Viral Viral load virus widespread [DOI] 10.7171/jbt.21-3203-011 PMC 바로가기 [Article Type] Article
MiR-200c-3p expression may be associated with worsening of the clinical course of patients with COVID-19Original Article Published on 2021-09-012022-10-30 Journal: Molecular Biology Research Communications [Category] COVID-19, [키워드] affected Biomarkers Clinical course condition COVID-19 expression expression level Factor greater group groups host cell independent Infection mechanism microRNA Oxygen therapy Patient patients with COVID-19 positive public health emergency qPCR regression analysis respiratory disorder Risk factors Saliva SARS-CoV-2 severity Symptomatic patients systemic arterial hypertension worsening [DOI] 10.22099/mbrc.2021.40555.1631 PMC 바로가기 [Article Type] Original Article