Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Ion Channel Activity Promotes Virus Fitness and Pathogenesis
Research Article
[키워드] absence
accompanied
Activation
activity
acute respiratory distress
Affect
airway
Amino acid
ARDS
assays
ATPase
attenuate
Cell
channel
compensatory mutation
complexes
Concentration
correlated
Critical
cytokine
cytosolic
death
Deletion
demonstrated
died
disease
Diseases
displaying
E gene
E protein
edema
ENCODE
envelope
eventually death
experiment
fitness
highly pathogenic
IL-1β
IL-6
in viral
induce
inducer
Infection
infections
Inflammasome
inflammasome activation
Inflammatory cytokine
Inflammatory response
innate immune system
Interaction
involved
Ion
ion homeostasis
less
Level
lost weight
lung
lung damage
lung epithelia
macromolecular
maturation
mechanism
mice
multifunctional protein
mutant
mutant viruses
Mutation
outcome
Pathogenesis
pathology
produced
progression
promote
Protein
pulmonary damage
reduced
reducing
required
respiratory
restored
SARS-CoV
SARS-CoV E
SARS-CoV infection
sequence
severe hypoxemia
significantly
suppressed
survived
syndrome
therapy
this system
TNF
translated
transmembrane protein
Transport
viral infection
virulence
virus
virus
virus growth
virus pathogenesis
virus production
wild-type
[DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1004077 PMC 바로가기 [Article Type] Research Article