Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2Review Published on 2020-11-012023-07-12 Journal: The Journal of endocrinology [Category] SARS, [키워드] ACE2 angiotensin Corticosteroid COVID-19 Dexamethasone Glucocorticoid receptor nuclear receptor SARS-CoV-2 [DOI] 10.1530/JOE-20-0260 [Article Type] Review
What to expect from different drugs used in the treatment of COVID-19: A study on applications and in vivo and in vitro resultsResearch article Published on 2020-11-012022-10-05 Journal: European journal of pharmacology [Category] 치료법, 치료제, [키워드] Anticoagulants antivirals carried Chloroquine clinical study coronavirus COVID-19 Dexamethasone drug effective help in vitro result in vivo Ivermectin knowledge performed SARS-CoV-2 Spread suggested Treatment treatments for COVID-19 [DOI] 10.1016/j.ejphar.2020.173467 [Article Type] Research article
Preferential use of dexamethasone for fetal lung maturation in severe coronavirus disease 2019중증 코로나바이러스 질환 2019에서 태아 폐 성숙을 위한 덱사메타손의 우선 사용Case Reports Published on 2020-11-012022-09-11 Journal: American journal of obstetrics & gynecology MFM [Category] SARS, 신약개발, 치료제, [키워드] Dexamethasone fetal lung maturation severe coronavirus disease [DOI] 10.1016/j.ajogmf.2020.100218 PMC 바로가기 [Article Type] Case Reports
Differentiation of COVID-19 Pneumonitis and ICI Induced PneumonitisOncology Published on 2020-10-292022-10-31 Journal: Frontiers in Oncology [Category] COVID-19, [키워드] acute respiratory syndrome adverse event Algorithm caused clinician CO-RADS coronavirus COVID-19 COVID-19 pandemic Dexamethasone diagnose Diagnosis diagnostic differentiation early stage evaluated immune check inhibitor (ICI) Immunosuppression immunosuppressive increased risk induced Infection infection with SARS-CoV-2 inhibitor overlapping patients treated Patients with cancer Phase III trials Pneumonia Pneumonitis progression radiological feature Remdesivir reported respiratory symptom risk factor SARS-CoV-2 serious complication severe coronavirus disease severe COVID-19 shown Standard of care therapy treated Treatment Vaccine [DOI] 10.3389/fonc.2020.577696 PMC 바로가기 [Article Type] Oncology
Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trialCOVID-19로 병원에 입원한 환자의 Lopinavir-ritonavir(RECOVERY): 무작위, 통제, 공개, 플랫폼 시험Randomized Controlled Trial Published on 2020-10-242022-08-13 Journal: Lancet (London, England) [Category] 임상, [키워드] 28-day mortality 95% CI active treatment all-cause mortality allocation concealment assigned Azithromycin baseline both groups by mouth composite endpoint death Dexamethasone died discharge discharged eligible finding funding groups hospital Hospital stay Hydroxychloroquine IMPROVE in both groups in vitro activity intention-to-treat basis Invasive mechanical ventilation ISRCTN Lopinavir Lopinavir–ritonavir median Medical Research Council mouth no significant difference observational studies Open-label outcome Participants Patient Platform trial preclinical studies Primary outcome proportion randomisation randomised Randomised trial Randomly rate ratio receive recovery reductions reductions in Registered Result risk risk ratio Ritonavir Standard of care subgroups of patients Support the patient treat Treatment treatment for COVID-19 treatment group Trial usual care web-based simple with COVID-19 [DOI] 10.1016/S0140-6736(20)32013-4 PMC 바로가기 [Article Type] Randomized Controlled Trial
Potential therapeutic use of corticosteroids as SARS CoV-2 main protease inhibitors: a computational studyResearch Article Published on 2020-10-232023-07-01 Journal: Journal of biomolecular structure & dynamics [Category] SARS, [키워드] Corticosteroids COVID-19 Dexamethasone docking and molecular dynamics simulation SARS CoV-2 main protease [DOI] 10.1080/07391102.2020.1835728 PMC 바로가기 [Article Type] Research Article
Computational studies reveal mechanism by which quinone derivatives can inhibit SARS-CoV-2. Study of embelin and two therapeutic compounds of interest, methyl prednisolone and dexamethasoneOriginal Article Published on 2020-10-142023-07-01 Journal: Journal of infection and public health [Category] SARS, [키워드] COVID-19 Dexamethasone embelin methyl prednisolone vitamin K [DOI] 10.1016/j.jiph.2020.09.015 PMC 바로가기 [Article Type] Original Article
Unfortunate Outcomes in Patients With SARS-CoV-2 Superimposed on Pneumococcal PneumoniaInternal Medicine Published on 2020-10-142022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Antibiotics Bacterial infection clinical condition complicate coronavirus COVID-19 COVID-19 outbreak death Deterioration Dexamethasone disease Health Hypoxemia implication management organ Oxygenation Patient PCR pneumococcal pneumococcal antigen Pneumonia polymerase chain positive Remdesivir SARS-CoV-2 the disease the patient the United State treated Urine virus [DOI] 10.7759/cureus.10939 PMC 바로가기 [Article Type] Internal Medicine
Comparison of Efficacy of Dexamethasone and Methylprednisolone in Improving PaO2/FiO2 Ratio Among COVID-19 PatientsInternal Medicine Published on 2020-10-122022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome administration anti-inflammatory treatment Antiviral C-reactive protein calculated Clinicians coronavirus coronavirus disease covid induced ards COVID-19 COVID-19 patients CRP cytokines release syndrome Dexamethasone distress drug effective Effectiveness eight global pandemic group Host immune reaction Improving inflammation markers inflammatory markers initial less Methylprednisolone Oxygenation P/F P/F ratio PaO paO2/fiO2 participant Participants Patient Ratio ratio of partial pressure of arterial oxygen and fraction of inspired oxygen recorded reduced Result retrospective SARS-CoV-2 serum ferritin level significantly steroid therapy Study design syndrome t-test two group viral replication was used Wuhan, China [DOI] 10.7759/cureus.10918 PMC 바로가기 [Article Type] Internal Medicine
A case report of toxic epidermal necrolysis (TEN) in a patient with COVID-19 treated with hydroxychloroquine: are these two partners in crime?Case Report Published on 2020-10-062022-11-01 Journal: Clinical and Molecular Allergy : CMA [Category] COVID-19, [키워드] Activation Adverse Adverse Drug Reaction (ADR) ALDEN Algorithm Algorithm Antibiotics Atypical Blister calculated cardiometabolic Case report caused clinical evidence COVID 19 COVID-19 COVID-19 positive patient Cutaneous detect Dexamethasone drug epidermal extension highest Hydroxychloroquine immune system knowledge lesion less low-molecular-weight-heparin Manifestations mucous membrane Necrolysis off-label Other outcome pandemic Paracetamol Patient patient with COVID-19 pharmacovigilance potassium canrenoate Rash reaction regimen respiratory retrieved SARS-CoV- 2 SCORTEN Score Severe Cutaneous Adverse Reactions (SCAR) Stevens–Johnson Syndrome (SJS) syndrome the patient total body Toxic Epidermal Necrolysis (TEN) toxicities treated virus widespread [DOI] 10.1186/s12948-020-00133-6 PMC 바로가기 [Article Type] Case Report