Household medication safety practices during the COVID-19 pandemic: a descriptive qualitative study protocolCOVID-19 전염병 동안 가정용 의약품 안전 관행: 기술적인 정성적 연구 프로토콜Multicenter Study Published on 2020-11-242022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 치료제, [키워드] Analysis approach approvals benefit best college comparative method Contact contact with COVID-19 COVID-19 pandemic Data analysis develop disseminate dissemination eligible Ethics for inclusion General population greater Guidance household identify individual Ireland Limerick list media medication pandemic participant Participants Patient peer-reviewed Perspective PPI primary care problem public health qualitative research recorded recruit reducing reported risk semistructured interviews social media Study protocol supported Therapeutics Trinity university University College London [DOI] 10.1136/bmjopen-2020-044441 PMC 바로가기 [Article Type] Multicenter Study
Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19): a structured summary of a study protocol for a randomized controlled trialCOVID-19(IVERCOR-COVID19) 환자의 입원을 방지하기 위한 Ivermectin: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Randomized Controlled Trial Published on 2020-11-242022-08-13 Journal: Trials [Category] SARS, 임상, 치료기술, [키워드] 1:1 acute infectious disease addition adherence administration Admission adverse event adverse events age allergy analyzed Anthropometric data antiviral drug antiviral drugs Arm ARMS assessment barrier basal blinded Breastfeeding breastfeeding women Cardiology Care care providers carried cause Chain Reaction childbearing age Chloroquine cirrhosis component components Concomitant Concomitant medication Confirmed connection contraceptive method contraceptives Control control group control groups coordination Corriente COVID-19 COVID-19 patient population criteria current Day death demographic demographic data Diagnosis diagnosis of COVID-19 dialysis discharged dissemination dose double-blind drug Efficacy Efficacy and safety elapsed element EOS Equal example exclusion criteria Final final visit first dose Follow-up greater heart rate Hospitalization hospitalizations Hydroxychloroquine incidence include Inclusion inclusion criteria inclusion/exclusion criteria Informed consent Intervention Invasive mechanical ventilation investigator investigators Ivermectin Ivermectin safety Laboratory less liver Liver cirrhosis Liver disease mal-absorptive syndrome medical history medication menstrual menstrual cycles Mortality negative Negative PCR number objective outcome outcome assessor outcome assessors over oxygen oxygen saturation parallel group participant Participants Participation Patient patients with COVID-19 PCR PCR swab Placebo placebo-controlled study polymerase chain polymerase chain reaction Polymerase chain reaction test postmenopausal pregnant Presence Prevent Primary outcome protocol Public public health randomization Randomized Randomized controlled trial randomly permuted blocks receive recommendation recorded recruitment reducing renal replacement therapy replacement therapy reproductive required Research Sample size SARS-CoV2 secondary severe liver disease single-center standard treatment standard treatment alone Study protocol supplementary material surgical Swab table Tablet temperature the patient Total Treatment Trial Trial registration use of hydroxychloroquine Version Viral viral pathology Vital vital signs vital status web system website weight woman women [DOI] 10.1186/s13063-020-04813-1 PMC 바로가기 [Article Type] Randomized Controlled Trial
Modeling and interpreting the COVID-19 intervention strategy of China: A human mobility viewResearch Article Published on 2020-11-242022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] alleviate analyzed applied approach China Chinese country COVID-19 dataset dissemination Epidemic epidemiological hazard Interpretation Intervention lockdown mitigate modeling outbreak pandemic parameter prevalent Prevent public health Public health intervention risk Spread the disease the epidemic Transmission virus Volume Wuhan [DOI] 10.1371/journal.pone.0242761 PMC 바로가기 [Article Type] Research Article
In-situ Simulation Use for Rapid Implementation and Process Improvement of COVID-19 Airway ManagementEndemic Infections Published on 2020-11-242022-10-28 Journal: Western Journal of Emergency Medicine [Category] Coronavirus, SARS, [키워드] 95% confidence interval airway airway management Algorithm assist authors average Care coronavirus disease COVID-19 dissemination effective Epidemic feedback frontline healthcare workers high-risk procedure improvement intubation Likert scale Nurses over pandemic participant participated Patient patient with COVID-19 patients with COVID-19 Personal protective equipment physician Physicians Process process improvement Rapid response Result retrospective significant increase significantly Simulation unique [DOI] 10.5811/westjem.2020.7.48159 PMC 바로가기 [Article Type] Endemic Infections
Safety and efficacy of herbal extracts to restore respiratory health and improve innate immunity in COVID-19 positive patients with mild to moderate severity: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-232022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 administer Administered allergic Analysis Asparagus automatically Ayurveda CAM CAP Capsule clinical coded COVID COVID 19 COVID-19 COVID-19 positive patient CTRI Date declining dissemination Dizziness dose double blind drop-outs early recovery Efficacy element eligible Embelia enrolled enrolment exploratory Follow-up function ginger glycyrrhiza Health health condition Herbal Herbo-mineral IL6 IMPROVE in viral India Infection Innate immunity Intervention intervention group investigator Last Medicine Memorial Mild moderate number objective outcome parallel group participant Patient patients with COVID-19 positive positive patient positive RT-PCR product protocol racemosus randomised randomised controlled trial Randomized Rash recruitment reducing Registered registration number registry Safe Safety Sample size screened secondary Shankha status study period Study protocol submission Test Th17 the disease the placebo group Treatment Trial two group two groups Viral load website were blinded Zinc Zingiber [DOI] 10.1186/s13063-020-04906-x PMC 바로가기 [Article Type] Letter
Comparison of four COVID-19 screening strategies to facilitate early case identification within the homeless shelter population: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-232022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 90% power accompany addition All participant amplified applied blinded Canada Care city clinically Cluster collected Community comparator Comparator group computation computer-generated correlation COVID case COVID-19 COVID-19 testing detect detection rate dissemination Effectiveness eight element eligible envelope error rate estimate facilitate Frame Gender group homeless include information initial intervention arm intervention group Laboratory marker medium Nasopharyngeal swab nostril NPs nucleic acid number objective Older Open-label oral swab participant percentage performed positive prevention protocol Qualitative random assignment randomised controlled trial randomization randomize Randomized randomized trial receive recruitment regimen Registered Registration repeated required Respiratory illness RNase P RT-PCR Sample size SARS-CoV-2 Screening screening strategy secondary shelter specimen specimens Standard of care statistically significant status stratified study enrollment study period Study protocol Surveillance Swab swab sample swabs Symptom symptomatic participant Symptoms tongue transported Trial type I UTR verbal viral inactivation website [DOI] 10.1186/s13063-020-04890-2 PMC 바로가기 [Article Type] Letter
Prone positioning in non-intubated patients with COVID-19 associated acute respiratory failure, the PRO-CARF trial: A structured summary of a study protocol for a randomised controlled trialLetter Published on 2020-11-232022-10-29 Journal: Trials [Category] COVID-19, SARS, [키워드] 1:1 Acute respiratory failure Alpha Altered mental status approval asked awake prone-positioning blinded block calculated Chest clinical clinically contraindication control group Controlled trial COVID-19 data analyst decrease dissemination element eligibility eligible endotracheal Endotracheal intubation expected facial failure fatigue for inclusion fraction High-flow nasal cannula in both group intervention group intubation rate Invasive mechanical ventilation less Local maintain mechanical ventilation median MONITOR monitoring nasal need for oxygen non-intubated patient number objective offered outcome oxygen parallel group participant Patient patients patients with COVID-19 Pelvic Physicians Pillow positioning positive Pregnancy principal investigator prone Prone position prone positioning protocol randomised randomised controlled trial randomization Randomized Randomly recruit refusal Registered reported respiratory Respiratory failure Sample size screened staff Standard status stratified Study protocol supplementary material supplementary oxygen the patient therapy Thoracic Tolerance trauma Treatment vital sign website with COVID-19 [DOI] 10.1186/s13063-020-04882-2 PMC 바로가기 [Article Type] Letter
Screening marine algae metabolites as high-affinity inhibitors of SARS-CoV-2 main protease (3CLpro): an in silico analysis to identify novel drug candidates to combat COVID-19 pandemicArticle Published on 2020-11-212022-10-27 Journal: Applied Biological Chemistry [Category] COVID-19, [키워드] 3CLpro Absorption Analysis binding energy Callophysin A catalytic clinical trials clinically complex Compound compounds Computational approaches COVID-19 COVID-19 pandemic Cys145 database dissemination docking docking affinity drug candidate excretion free energy His41 hydrogen bonds hydrophobic interactions identify in silico analysis in vitro in vivo indicated inhibitor inhibitors of SARS-CoV-2 Marine-derived compounds metabolite Molecular docking and simulation molecular dynamics pandemic protease residue Salt Bridge SARS-CoV-2 screened Screening Seaweeds stability Stage suggested Virtual screening was performed Wuhan [DOI] 10.1186/s13765-020-00564-4 PMC 바로가기 [Article Type] Article
Zilucoplan in patients with acute hypoxic respiratory failure due to COVID-19 (ZILU-COV): A structured summary of a study protocol for a randomised controlled trialCOVID-19(ZILU-COV)로 인한 급성 저산소 호흡 부전 환자의 질루코플란: 무작위 대조 시험을 위한 연구 프로토콜의 구조화된 요약Letter Published on 2020-11-192022-08-13 Journal: Trials [Category] SARS, 임상, [키워드] 24 hour 24 hours acute hypoxic respiratory failure acute lung injury acute respiratory distress syndrome addition Adult patient alveolar pressure antibiotic Antibiotics anticipated arterial pressure Bacterial blinded Blinding Caregivers ceftriaxone characterized ciprofloxacin clinical Clinical course Combination comparator comparator Patients complement complement C5 inhibition complement pathways complement system component components control arm control group COVID-19 COVID-19 patient CT scan Cytokine release syndrome defined discharge discharged patient discharged patients disease dissemination Effect Efficacy and safety element eligibility criteria EudraCT exclusion criteria experimental arm Fungal infection history hospital discharge hospitalized patient hospitalized patients hospitals hypoxia hypoxic respiratory failure ICU ICUs Identifier improving oxygenation inclusion criteria individual Infection inhibiting inhibitor Interactive Web Response System invasive IV infusion LDH lead lung Lung injury lymphopenia Mechanical mechanical ventilation median meningococcal disease meningococcal infections number objective Open-label open-label trial outcome oxygen oxygen) Oxygenation pandemic PaO parameters Partial participant Participants Patient Phase 2 predict predisposition primary endpoint promote prophylactic antibiotics protocol randomisation randomised randomised controlled trial randomization Randomized receive recent recruited recruitment REDCap Registered repair mechanism Respiratory failure response Sample size SARS-COV-2 infection Serum ferritin SIGN SpO2 Standard of care status Study protocol subcutaneously supplemental oxygen supplementary material System systemic cytokine release syndrome Trial Trial registration Ventilation Version Web website zilucoplan [DOI] 10.1186/s13063-020-04884-0 PMC 바로가기 [Article Type] Letter
The COVID-19 pandemic: broad partnerships for the rapid scale up of innovative virtual approaches for capacity building and credible information dissemination in AfricaSeminar Published on 2020-11-192022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, [키워드] Africa approach associations center Community confirmed case Corona country COVID-19 Critical disseminate dissemination East Epidemic Health health worker hospital information International Health Regulations Intervention mitigate New Nurse outbreak pandemic participant physical distancing measures Physicians platform practitioners professional public health public health emergency Responding Science Spread Support university Virtual training West while WHO World Health Organization [DOI] 10.11604/pamj.2020.37.255.23787 PMC 바로가기 [Article Type] Seminar