Impact of Coronavirus disease (COVID-19) pandemic on health professionalsOriginal Article Published on 2020-05-012022-10-29 Journal: Pakistan Journal of Medical Sciences [Category] COVID-19, [키워드] affecting Analysis approach carried challenges clinician conducted Coping strategy COVID-19 COVID-19 pandemic creating cross-sectional disease disease outbreaks Future Health Health professionals hospital Impact iterative Mental pandemic Pandemics participant physical professional qualitative data reached reported Research Safe Sample size Support work-life balance [DOI] 10.12669/pjms.36.COVID19-S4.2779 PMC 바로가기 [Article Type] Original Article
COVID-19 and smoking: A systematic review of the evidenceEditorial Published on 2020-03-202022-10-28 Journal: Tobacco Induced Diseases [Category] COVID-19, [키워드] 2019 novel coronavirus 2019-nCoV Admission adverse outcome adverse outcomes Analysis association assumed autonomous available data calculate Care changes in Characteristics chest radiology China clinical Clinical characteristics Clinical outcome clinical symptom clinically cohort study conducted coronavirus Course COVID-19 COVID-19 pandemic current database death deaths detrimental diagnosed died discharged disease Disease progression English epidemiological evaluate Evidence Factor feature FIVE former Health hospital hospitalisation hospitalised patient Hospitalization humans ICU ICU care immune system inclusion criteria Increases indicated individual infected with COVID-19 infected with SARS-CoV-2 infections Infectious disease Influenza information Inpatient intensive care Italy Laboratory laboratory-confirmed Logistic regression Logistic regression analysis lung majority mechanical ventilation MERS-CoV Mortality mortality risk factor multicenter cohort study multicentre multivariate multivariate logistic regression negative non-ICU non-severe patient non-survivor outbreak outcome pandemic Patient patients patients died patients with COVID-19 percentage plethora Population positive previous study Prognosis Prognostic factor progression proportion Prospective provided pulmonary ranged Region regions reported Research Respiratory disease retrieved retrospective retrospective cohort study risk factor Sample size searched setting Severe case Severe patient severe symptom severe symptoms severity shown significantly higher small sample size smoker Smokers smoking smoking status statistical analysis statistically significant statistically significant difference Study design study population Support survived survivor Symptom Symptoms systematic review table tested the disease the patient those that survived title Tobacco two group were excluded were used with COVID-19 Wuhan Wuhan, China [DOI] 10.18332/tid/119324 PMC 바로가기 [Article Type] Editorial
Comparative studies of alignment, alignment-free and SVM based approaches for predicting the hosts of viruses based on viral sequencesArticle Published on 2018-07-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] applied approach Comparative conserved coronavirus correlated dinucleotide Diseases Frequency gene sequences Host influenza A virus influenza A viruses investigated K -mer pandemic predict Rabies virus Sample size sequence spike gene Support Surveillance SVM time-consuming Variability viral sequence virus viruses [DOI] 10.1038/s41598-018-28308-x PMC 바로가기 [Article Type] Article
Treatment of Middle East Respiratory Syndrome with a combination of lopinavir-ritonavir and interferon-β1b (MIRACLE trial): study protocol for a randomized controlled trialStudy Protocol Published on 2018-01-302022-10-29 Journal: Trials [Category] Coronavirus, [키워드] adjust Antiviral center clinical trial Combination components coronavirus Coronavirus infection determine double-blind effective Efficacy enrolled Hospital admission in vitro include Interferon-β1b investigated King laboratory-confirmed Lopinavir-ritonavir Lopinavir/ritonavir MERS MERS-CoV Middle East Mortality multicenter Patient Placebo placebo-controlled Potential treatment Primary outcome protocol provided randomized clinical trials Randomized controlled trial respiratory Result Sample size Saudi Arabia specific treatment Standard standard supportive care Study protocol supplementary material Treatment Trial was recorded [DOI] 10.1186/s13063-017-2427-0 PMC 바로가기 [Article Type] Study Protocol
A case-control collapsing analysis identifies epilepsy genes implicated in trio sequencing studies focused on de novo mutations사례 대조 붕괴 분석은 새로운 돌연변이에 초점을 맞춘 트리오 시퀀싱 연구와 관련된 간질 유전자를 식별합니다Research Article Published on 2017-11-292022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition adopted Analysis approach can be used Case-control Collapsing controls datasets de novo de novo mutation de novo mutations disease disorders dominant effective enrichment epilepsy epileptic encephalopathy evaluate Exome expected filtered form Genes genome-wide significance identify implicated KCNT1 large cohort life majority Mutation offer parent parents pathogenic performed predicted proportion Protein protein-coding gene protein-coding genes rare variant responsible Sample size sample sizes SCN2A selected sequence Sequencing significantly significantly higher STXBP1 Support Trio variant variants Variation [DOI] 10.1371/journal.pgen.1007104 PMC 바로가기 [Article Type] Research Article
Detectable Risks in Studies of the Fetal Benefits of Maternal Influenza VaccinationArticle Published on 2016-08-012023-06-23 Journal: American journal of epidemiology [Category] 신종인플루엔자, [키워드] immunization influenza illness influenza vaccine Pregnancy pregnancy complication Preterm birth Sample size Statistical power [DOI] 10.1093/aje/kww048 PMC 바로가기
Risk based surveillance for early detection of low pathogenic avian influenza outbreaks in layer chickensArticle Published on 2014-11-012023-06-01 Journal: Preventive veterinary medicine [Category] 조류인플루엔자, [키워드] Avian Influenza Early detection LPAI Risk-based surveillance Sample size Sampling frequency surveillance. [DOI] 10.1016/j.prevetmed.2014.08.015 PMC 바로가기
Gene-Environment Dependence Creates Spurious Gene-Environment Interaction유전자-환경 의존성은 가짜 유전자-환경 상호작용을 생성한다Report Published on 2014-09-042022-08-07 Journal: American Journal of Human Genetics [Category] 유전자 메커니즘, [키워드] Accuracy addition biological processe biological processes can not causal variant condition dependence disease epidemiological example gene-environment dependence gene-environment interaction genetic marker Genetic markers IMPROVE in addition to independent Interaction leads Linkage disequilibrium marker mediation no interaction Pleiotropy power risk Sample size shown SNP Spurious statistical interaction susceptible [DOI] 10.1016/j.ajhg.2014.07.014 PMC 바로가기 [Article Type] Report
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry비만의 유전자 × 신체 활동 상호 작용: 유럽 조상 111,421명의 통합 분석Research Article Published on 2013-07-252022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activity Adult Adults age aggregate effect allele analyses Analysis analysis ancestry attenuate Author BMI calculated Characteristics Cohort cohorts Combined cumulative cumulative effect detected diminishe environmental exposure European Europeans Evidence evidence of examined FTO gene × environment interactions genetic risk genetic risk score Genetic variant Genome-wide association studies genotyped GRS heterogeneity Inclusion indicated individual inefficient inhibit Interaction interaction effect interactions knowledge Li linear loci locus logistic regression model meta-analyses meta-analysis Meta-analysis multicenter Multiplicative interaction Multiplicative interactions North North America nucleotide Numerous obesity Participants physical activity provide Questionnaires replicated Replication reported Sample size SEC16B Secondary analyses Sex single nucleotide polymorphisms SNP SNP × physical activity interactions statistically significant Support tested treated variant [DOI] 10.1371/journal.pgen.1003607 PMC 바로가기 [Article Type] Research Article
Imputation-Based Meta-Analysis of Severe Malaria in Three African Populations세 아프리카 인구에서 심각한 말라리아의 대치 기반 메타 분석Research Article Published on 2013-05-232022-09-12 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Affect affected African allele alleles Analysis approach approach association assumption Author Bayesian approach Bayesian approaches Blood blood type cause Cell children Community complex conducted confounding effect Control country detect different disease DNA variant ethnic group Ethnic groups Europe European feasibility fixed genes ABO genetic diversity genetic risk factor genetic risk factors genetics Genome-wide association studies Genome-wide association study genome-wide data genomic location genotype imputation GWAS Haemoglobin Haplotype HBB healthy individual heterogeneity heterogeneous individual Kenya kill location malaria malaria susceptibility loci Meta-analysis multicentre observation Population populations risk S allele Sample size sample sizes severe severe malaria sickle cell Sickle cell disease sickle cell disease) statistical model statistical test Statistical tests strength [DOI] 10.1371/journal.pgen.1003509 PMC 바로가기 [Article Type] Research Article