Broad-Spectrum Coronavirus Fusion Inhibitors to Combat COVID-19 and Other Emerging Coronavirus DiseasesReview Published on 2020-05-282022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibodies antibody antiviral drug approved caused characterized combat conserved coronavirus coronavirus disease COVID-19 Disadvantages Diseases drug drugs targeting Entry inhibitor fusion fusion inhibitor inhibitors MERS Middle East Novel coronavirus Other pathogen peptide Protease inhibitor protease inhibitors SARS Coronavirus SARS-CoV-2 syndrome Transmissibility Vaccine Vaccines [DOI] 10.3390/ijms21113843 PMC 바로가기 [Article Type] Review
Trends and Innovations in Biosensors for COVID‐19 Mass TestingMinireview Published on 2020-05-272022-10-31 Journal: Chembiochem [Category] COVID-19, MERS, SARS, [키워드] accelerate antibody assays benefit Biomarker biosensor Blood circumvent COVID-19 COVID‐19 CRISPR CRISPR Diagnostics Diagnosis diagnostic diagnostics DNA amplification DNA sequencing ENhance equipment immunoassay immunoassays Infectious disease Innovation isothermal isothermal amplification mass molecular molecular diagnostics outbreak pandemic point‐of‐care test polymerase chain Quantitative Rapid test respond reverse transcription sensitivity Sensitivity and specificity serological specificity Swab Testing trend Viral protein Viral RNA virus widespread [DOI] 10.1002/cbic.202000250 PMC 바로가기 [Article Type] Minireview
Human neutralizing antibodies elicited by SARS-CoV-2 infection Research Published on 2020-05-262022-10-05 Journal: Nature [Category] SARS, 유전자 메커니즘, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 Anti-RBD antibody anti-SARS-CoV-2 antibody antibody binding candidate caused cellular receptor coronavirus coronavirus disease COVID-19 cross-react cross-reactivity elicited entry of SARS-CoV-2 health emergency Human individual infected with SARS-CoV-2 inhibit inhibitors Intervention Isolation MERS-CoV Middle East monoclonal antibody neutralize neutralizing antibody pandemic plasma Proteins RBD SARS-CoV SARS-CoV-2 SARS-COV-2 infection single B cell steric hindrance target cell the RBD the receptor-binding domain trimeric spike viral entry viral spike protein [DOI] 10.1038/s41586-020-2380-z [Article Type] Research
Core Outcome Set for Clinical Trials of COVID-19 Based on Traditional Chinese and Western MedicinePharmacology Published on 2020-05-252022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] antibody Blood blood gas analysis Blood oxygen saturation C-reactive protein Chinese clinical Clinical efficacy Clinical outcome clinical symptom clinical trial clinical trials conducted Consensus core Core outcome set COVID-19 DelPhi development disease eligible etiology heterogeneity IMPROVE Inflammatory limitation Lymphocytes mechanical ventilation Medicine methodology mild-to-moderate disease Nurses outcome oxygen pandemic PaO2/FiO2 ratio parameter participated Patient Pneumonia Severity Index Prevalence progression protocol questionnaire Research Respiratory outcome Result SARS-CoV-2 severe disease Study protocol Symptom systematic review TCM temperature Traditional Traditional Chinese medicine Viral load virus vital sign Western medicine [DOI] 10.3389/fphar.2020.00781 PMC 바로가기 [Article Type] Pharmacology
Harnessing the power of novel animal-free test methods for the development of COVID-19 drugs and vaccinesGuest Editorial Published on 2020-05-232022-10-28 Journal: Archives of Toxicology [Category] COVID-19, MERS, SARS, [키워드] accelerated antibody approach approaches biological processe carcinogenicity country COVID-19 Critical drug Drug discovery Efficacy EMA epitope European Medicines Agency feature Health Laboratory limitation Molecular biology Organoid pandemic pathogen predict resource SARS-CoV2 supplementary material Vaccine virus virus infectivity [DOI] 10.1007/s00204-020-02787-2 PMC 바로가기 [Article Type] Guest Editorial
Development of multi-specific humanized llama antibodies blocking SARS-CoV-2/ACE2 interaction with high affinity and avidityLetter Published on 2020-05-222022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, [키워드] ACE2 receptor antibody approach bi-specific antibody binding Combination combination therapies contribute COVID-19 development diagnostics domains facilitate high affinity host cell host cell membranes humanized humanized antibody in-silico Interaction limitation llama antibody MERS monoclonal MOST multiple mechanism nanobody overcome pandemic polyclonal Protein S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus significantly synergistic therapeutic tri-specific antibody trimeric spike unique viral disease virus entry [DOI] 10.1080/22221751.2020.1768806 PMC 바로가기 [Article Type] Letter
Immunogenicity of a DNA vaccine candidate for COVID-19Article Published on 2020-05-202022-10-04 Journal: Nature Communications [Category] MERS, 치료기술, [키워드] ACE2 receptor antibodies antibody Antigen binding biodistribution build cellular immunity clinical study coronavirus Coronaviruses COVID-19 COVID-19 vaccine dataset disease dissemination DNA vaccine DNA vaccines expression functional generate identify immunization immunogenicity in vitro Infection initial INO-4800 Lungs MERS coronavirus mice neutralize Neutralizing antibody response pandemic Protein robust SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 vaccine spike Support T cell T cell responses the disease the S protein the SARS-CoV-2 translational Vaccine vaccine candidate Viral pneumonia [DOI] 10.1038/s41467-020-16505-0 PMC 바로가기 [Article Type] Article
Antibody Tests in Detecting SARS-CoV-2 Infection: A Meta-AnalysisArticle Published on 2020-05-192022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] acid antibody Antibody test caused CLIA Coronavirus disease 2019 COVID-19 diagnostic test ELISA ELISA test enzyme-linked immunosorbent assay evaluated Flow Fluorescence gold standard identify IgG IgG test IgM IgM and IgG imperative Inconclusive individuals Infection Lateral LFIA LFIA test Meta-analysis onset of symptoms pandemic performed S antigen SARS-CoV-2 sensitivity serological test Specificities specificity systematic review Test [DOI] 10.3390/diagnostics10050319 PMC 바로가기 [Article Type] Article
Key residues of the receptor binding motif in the spike protein of SARS-CoV-2 that interact with ACE2 and neutralizing antibodiesArticle Published on 2020-05-152022-11-01 Journal: Cellular and Molecular Immunology [Category] COVID-19, SARS, [키워드] ACE2 against SARS-CoV amino acid residue analyzed angiotensin-converting enzyme 2 antibody antigenic bind binding site block viral entry caused Coronavirus disease 2019 coronavirus SARS-CoV-2 COVID-19 COVID-19 pandemic cross-neutralizing cross-neutralizing antibody develop drug epitope F486 feature host receptor human ACE2 Humoral immunity immunization in vivo experiment indicate induce Infection mechanism neutralize Neutralizing antibodies neutralizing antibody neutralizing monoclonal antibody Prophylactic public health RBD receptor binding motif recognize representing residue SARS-CoV SARS-CoV RBD SARS-CoV-2 SARS-CoV-2 RBD Spike protein Substitution mutation the RBD the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine viral spike protein viruses [DOI] 10.1038/s41423-020-0458-z PMC 바로가기 [Article Type] Article
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoVSARS-CoV-2 및 SARS-CoV의 수용체 결합 도메인에서 고도로 보존된 비밀 에피토프Report Published on 2020-05-082022-09-14 Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단, 치료제, [키워드] antibody Antibody Response antigenicity bind binding binding epitope caused competent complex conserved convalescent convalescent SARS patient coronavirus disease COVID-19 CR3022 cross-reactive distal elicit epitope host cell molecular neutralizing antibody outbreak pandemic Patient Protein RBD receptor Receptor binding domain receptor binding site receptors SARS-CoV SARS-CoV-2 Science spike Spike protein target targeting the receptor-binding domain the SARS-CoV-2 trimeric S protein trimeric spike Vaccine design viral spike virus [DOI] 10.1126/science.abb7269 PMC 바로가기 [Article Type] Report