Phylogenetic distribution and predominant genotype of the avian infectious bronchitis virus in China during 2008-2009Research Published on 2011-04-222022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] age Amino acid amino acids sequence amplified Analysis bronchitis caused Characteristics China circulating cleavage site coding region death different distribution Gene Genotype homology IBV indicated infectious Infectious Bronchitis Virus isolate molecular MOST nucleotide Outbreaks pandemic predominant Prevalence Protein Result RT-PCR S1 protein sequenced strain Strains suggested trials Vaccine virus [DOI] 10.1186/1743-422X-8-184 PMC 바로가기 [Article Type] Research
Small Interfering RNA Effectively Inhibits the Expression of SARS Coronavirus Membrane Gene at Two Novel Targeting SitesArticle Published on 2010-10-182022-10-30 Journal: Molecules [Category] Coronavirus, [키워드] analyzed blocked conserved coronavirus Critical demonstrated downregulate downregulated Effect eGFP expression Gene Expression information interferon isolate isolates M gene membrane Membrane gene novel nucleotide nucleotide substitution occur post-transcriptionally Protein qRT-PCR Quantitative Region RNA RNA molecule RT-PCR SARS-CoV SARS-CoV infection SARS-CoV M semi-quantitative sequence significantly siRNA Site Small interfering RNA targeting tested upregulation viral genome viral infection [DOI] 10.3390/molecules15107197 PMC 바로가기 [Article Type] Article
SARS coronavirus protein 7a interacts with human Ap 4 A-hydrolaseResearch Published on 2010-02-092022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] activated Activation Amino acid Apoptosis cell proliferation cellular co-immunoprecipitation culture cell cytoplasm DNA repair DNA replication ENCODE expressing Frame Host Human human cell interact Interaction involved nucleotide ORF pathogenic processe Protein protein synthesis Proteins Regulation responsible RNA SARS Coronavirus SARS-CoV sequence homology shown tissue virus yeast [DOI] 10.1186/1743-422X-7-31 PMC 바로가기 [Article Type] Research
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 ActivationResearch Article Published on 2008-06-132022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] Activation ADP-ribosylation Analysis ARF ARF1 association Author cells cellular cellular pathway characteristic complex connection coronavirus Coronavirus replication Critical demonstrated dominant-negative downstream Endoplasmic reticulum Express expression Factors GBF1 GTPase GTPases guanine Host Human induce infected cell Infection inhibited inhibiting interfere involved knockdown MDCK cells membrane MHV Microscopy mouse mouse hepatitis mutant nucleotide observation provide Quantitative reduced Replication replication complex required RNA RNA virus secretory pathway significantly siRNA siRNAs structures target vesicles viruses [DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
Inhibition of SARS-CoV replication cycle by small interference RNAs silencing specific SARS proteins, 7a/7b, 3a/3b and SArticle Published on 2007-03-012022-10-06 Journal: Antiviral Research [Category] 진단, [키워드] accessory proteins acute respiratory syndrome aspecific assay coronavirus demonstrated Efficiency eight expressing expression full-length Genome genomic indirect immunofluorescence infected cell inhibit inhibition knockdown mRNA not affected nucleocapsid protein nucleotide Open reading frame ORF ORFs progeny Protein Proteins reduction in Replication RNA SARS CoV SARS-CoV sgRNA sgRNAs siRNA siRNAs specificity tested translated Vero E6 cell viral infection Viral protein virus were infected without affecting [DOI] 10.1016/j.antiviral.2006.10.008 PMC 바로가기 [Article Type] Article
Human coronavirus 229E encodes a single ORF4 protein between the spike and the envelope genesResearch Published on 2006-12-282022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 229E Accessory genes Amino acid amino acids Analysis analyzed CCU Cell culture Cold collected common conserved coronavirus coronavirus 229E determine ENCODE envelope gene FIVE Genes Genome genome organization HCoV-229E HCoV-NL63 homologue Human in vivo isolate Laboratory Netherland nucleotide ORF ORF3 protein ORF4b PEDV Protein Proteins prototype virus related Result sequence unit [DOI] 10.1186/1743-422X-3-106 PMC 바로가기 [Article Type] Research
Biological and genetic characterization of a hemagglutinating coronavirus isolated from a diarrhoeic childArticle Published on 2005-12-072022-11-01 Journal: Journal of medical virology [Category] Coronavirus, [키워드] activity acute diarrhea Amino acid amplification Analysis antigenic and nucleotide sequence comparisions BCV Biological caused cDNA Cell cell cultures cells coronavirus Cytopathic effect cytopathogenicity detected diarrhea DNA sequence electron microscopy Enteritis found Gene Genetic genomic homology human and bovine HA coronaviruses Inc Infected M gene monoclonal antibody nucleotide occurred Particle polymerase chain rectal related reverse transcription Strains viral RNA genome virulent virus [DOI] 10.1002/jmv.1890440207 PMC 바로가기 [Article Type] Article
Molecular Epidemiology of SARS-associated Coronavirus, BeijingResearch Published on 2005-09-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] amplified amplified products Beijing Characteristics clinical sample Cluster collected coronavirus different dominant Epidemics geographic location Guangdong Host immune pressure isolate loci molecular Molecular epidemiology motif Mutation nucleotide Patient patients reported RT-PCR RT-PCR, research SARS-CoV selective sequence Sequencing Severe acute respiratory syndrome single nucleotide variation SNV SNVs to define Variation viral adaptation were used [DOI] 10.3201/eid1109.040773 PMC 바로가기 [Article Type] Research
Genome structure and transcriptional regulation of human coronavirus NL63Research Published on 2004-11-172022-10-28 Journal: Virology Journal [Category] Coronavirus, [키워드] 2003 Analysis Cell culture coding codon usage compared Coronaviral coronavirus detect experimental analysis expression level GC content Genome genome structure HCoV-229E HCoV-NL63 HCoV-OC43 human coronavirus humans increase indicate indicated infect Inspection leader sequence mRNA mRNAs N proteins NL63 Northern blot analysis nucleocapsid nucleotide ORF3 other coronaviruses Pathogenesis pathogenicity performed powerful tool reflected Replication Result RNA genome SARS Coronavirus SARS-CoV sequenced significantly subgenomic mRNA subgenomic mRNAs Transcription transcriptional regulation viral evolution virus [DOI] 10.1186/1743-422X-1-7 PMC 바로가기 [Article Type] Research
Molecular analysis of S gene of spike glycoprotein of winter dysentery bovine coronavirus circulated in Korea during 2002–2003Short Communication Published on 2004-08-262022-11-01 Journal: Virus research [Category] Coronavirus, [키워드] Amino acid Analysis analyzed avirulent Bovine coronavirus Characteristics compared conducted coronavirus strain country diarrhea French Genetic Genetic characteristics glycoprotein homologous isolate Korean molecular analysis nucleotide Phylogenetic analysis related S gene S glycoprotein sequence significantly spike glycoprotein strain Strains the S1 subunit [DOI] 10.1016/j.virusres.2004.07.003 PMC 바로가기 [Article Type] Short Communication