Peripheral blood – Page 53 – Communicable Diseases Research

Presence of Genetic Variants Among Young Men With Severe COVID-19

Case Reports

Published on 2020-08-182022-10-04
Journal: JAMA [Category] MERS, 변종,

[키워드] acute respiratory syndrome affected age Analysis Blood carried case sery caused Cell chronic disease Control controls coronavirus coronavirus disease COVID-19 criteria died downregulated downstream experiments exposure Final finding Follow-up functional Genetic Genetic variant hospital ICU identify IFN IFN-γ IFNB1 immune defects immunodeficiency immunological Immunological test Importance individual intensive care interferon interferon signaling IRF7 ISG15 loss-of-function male measure mechanical ventilation Medical conditions men missense variant mononuclear cell mRNA expression Netherland Netherlands objective occur one patient participant pathogenesis of COVID-19 Patient patients patients hospitalized patients with COVID-19 performed Peripheral blood Point preliminary finding Presence primary immune cell Rapid Relevance responses Result SARS-CoV-2 setting severe coronavirus disease severe COVID-19 Severe infection Signaling significantly the mean the patient TLR7 transcriptionally type I type I interferon type II IFN variant ventilatory support whole-exome sequencing
[DOI] 10.1001/jama.2020.13719 PMC 바로가기 [Article Type] Case Reports

Distinguishing between COVID‐19 and influenza during the early stages by measurement of peripheral blood parameters

Research Article

Published on 2020-08-132022-11-01
Journal: Journal of medical virology [Category] COVID-19, Fulltext, MERS,

Sequence-based prediction of SARS-CoV-2 vaccine targets using a mass spectrometry-based bioinformatics predictor identifies immunogenic T cell epitopes

질량 분석 기반 생물정보학 예측자를 사용한 SARS-CoV-2 백신 표적의 서열 기반 예측으로 면역원성 T 세포 에피토프 식별

Research

Published on 2020-08-132022-08-13
Journal: Genome Medicine [Category] MERS, 유전자 메커니즘,

[키워드] allele alleles Antigen applied Asian binding bioinformatics CD4 CD8 Cell-mediated immunity characterized Computational biology Coronaviridae family Coverage COVID-19 COVID-19 pandemic database demonstrated Donor elicit epitope Epitopes European expression expression of SARS-CoV-2 healthy HLA allele HLA binding HLA-I binding prediction HLA-II binding prediction human leukocyte antigen humoral identify immune Immunity immunogenic infected cell leukocyte mass mass spectrometry mononuclear cell mononuclear cells Open reading frame open reading frames ORFs other coronavirus other coronaviruses PBMCs peptide peptides Peripheral blood platform populations positive predict predicted predictor protective immunity protective role Protein protein expression reported Result SARS-CoV-2 SARS-CoV-2 proteins SARS-CoV-2 T cell epitopes SARS-CoV-2 vaccine subset T cell T cell assay T cell epitope T cell epitopes T cell response T cell responses T cells target the Coronaviridae urgency Vaccine Vaccine design Validity Viral viral genome viral genomes
[DOI] 10.1186/s13073-020-00767-w PMC 바로가기 [Article Type] Research

Single-cell landscape of immunological responses in patients with COVID-19

Research

Published on 2020-08-122022-10-05
Journal: Nature Immunology [Category] SARS, 치료기술, 치료법,

A human circulating immune cell landscape in aging and COVID-19

Research Article

Published on 2020-08-112022-10-29
Journal: Protein & Cell [Category] COVID-19, MERS, SARS,

The Predictive Effectiveness of Blood Biochemical Indexes for the Severity of COVID-19

Research Article

Published on 2020-08-072022-10-31
Journal: The Canadian Journal of Infectious Diseases & Medical Microbiology = Journal Canadien des Maladies Infectieuses et de la Microbiologie Médicale [Category] COVID-19,

[키워드] absence affecting analyzed blood biochemical C-reactive protein center Clinical data collected Comorbidity cough COVID-19 COVID-19 patient COVID-19 severity CRP CRP level cured died discharged disease Effectiveness EMR enrolled erythrocyte sedimentation rate ESR Factor fatigue groups Hospitalization hypertension independent laboratory examination lymphocyte male median medical condition multivariate logistic regression objective Patient Peripheral blood Predictive predictor proportion Public Result severe disease severity of COVID-19 Symptom the disease the patient WBC were recorded were used White blood cell
[DOI] 10.1155/2020/7320813 PMC 바로가기 [Article Type] Research Article

Type III interferons disrupt the lung epithelial barrier upon viral recognition

Report

Published on 2020-08-072022-10-28
Journal: Science (New York, N.y.) [Category] COVID-19, MERS, SARS,

[키워드] aberrant immune response acute respiratory syndrome airway Antiviral antiviral immunity bacterial superinfections cause characterized Clinical practice contribute coronavirus coronavirus disease COVID-19 COVID-19 patient Critical critical COVID-19 patient dendritic cell disrupt driving elicit Endemic engage ENhance epithelial Evidence expressed expression functions IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs Immune cell immunopathology increase indicate induce Infection influenza infection Influenza virus inhibiting interfere ISGs Local Lower respiratory tract lung lung epithelial lung epithelium Major mice morbidity Mortality Mounting mucosal surface Necrosis p53 parameter Pathogenesis pathophysiological Patient Peripheral blood produced proinflammatory proliferation respiratory viral infections response responses RNA viruses SARS-CoV-2 Science secreted Severe case severity susceptibility therapeutic thought Transcription Trigger turn Type type I Type I IFN Type III IFN type III interferon viral burden viral infections viral respiratory disease viral respiratory infections Viral RNA viruses
[DOI] 10.1126/science.abc3545 PMC 바로가기 [Article Type] Report

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Report

Published on 2020-08-072022-10-06
Journal: Science (New York, N.y.) [Category] MERS, SARS, 진단,

[키워드] Analysis Antiviral antiviral immunity bacterial superinfections Blood cause characterized Cohort coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient Critical critical COVID-19 patient deficiency dendritic cell Disease progression disease severity driven by driving elicit engage ENhance epithelial exacerbated expressed expression functions hallmark host immune responses IFN IFN signaling IFN-stimulated gene IFN-α IFN-β IFN-λ IFNs immune Immune cell immunopathology Impaired increase Inflammatory response influenza infection inhibiting interfere interferon interleukin-6 ISGs Local lung lung epithelium Major mice morbidity mucosal surface Necrosis nuclear p53 parameter patients performed Peripheral blood phenotype proinflammatory proliferation respiratory viral infections response responses Science secreted severe COVID-19 severe COVID-19 patient severity Signaling susceptibility therapeutic therapeutic approaches thought Transcription transcriptional Trigger turn Type type I Type I IFN type I interferon Type III IFN viral infections Viral load viral respiratory disease viral respiratory infections Viral RNA
[DOI] 10.1126/science.abc6027 PMC 바로가기 [Article Type] Report

A dynamic COVID-19 immune signature includes associations with poor prognosis

Research

Published on 2020-08-012022-10-05
Journal: Nature Medicine [Category] SARS, 임상, 진단, 치료기술, 치료법,

SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19

Research

Published on 2020-07-292022-10-05
Journal: Nature [Category] SARS, 유전자 메커니즘, 치료기술,