Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparumArticle Published on 2013-07-122024-08-28 Journal: Brain stimulation [Category] 말라리아, [키워드] drug delivery malaria Plasmodium Transport yeast
Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegansCaenorhabditis elegans의 소포 수송에 의한 세포 간 프리온 도메인의 확산Research Article Published on 2013-03-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] aggregate aggregation ALS amyloid Amyotrophic lateral sclerosis animal model appearance asparagine Author autonomous autophagy Caenorhabditis Caenorhabditis elegan Caenorhabditis elegans Cell cellular cellular pathway conformation culture cell cytosolic Degradation developmental delay different disease Diseases domain elegan embryonic Encephalopathy Epigenetic Evidence exhibit expressed expressing expression form Glutamine hallmark hallmarks include infect infectious Lateral Sclerosis lobar lysosomal lysosomal vesicle mechanism misfolded protein misfolded proteins mitochondrial multicellular multicellular organism N-terminus naive cells neurodegenerative neurodegenerative disorders NM organism Parkinson's Disease pathology pathway prion Propagation Protein Proteins real time recent Spread spreading thought tissue tissue culture tissues Toxicity trait transgenic mice transmissible spongiform encephalopathies Transmission Transport underlie Vesicle vesicular widespread yeast [DOI] 10.1371/journal.pgen.1003351 PMC 바로가기 [Article Type] Research Article
SARS-CoV 9b Protein Diffuses into Nucleus, Undergoes Active Crm1 Mediated Nucleocytoplasmic Export and Triggers Apoptosis When Retained in the NucleusResearch Article Published on 2011-05-272022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] absence Affect Amino acid Apoptosis caspase-3 Cell cellular Critical death Degradation diffuse elevated export found host cell independent induce influence inhibitors interact Interaction Mediated NES NLS nuclear nuclear localization signal nucleus principal Protein SARS-CoV shown transiently transfected Transport Trigger [DOI] 10.1371/journal.pone.0019436 PMC 바로가기 [Article Type] Research Article
Zn 2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell CultureResearch Article Published on 2010-11-042022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] activity Antiviral arteritis arterivirus Author binding block both viruses catalyzed Cell Cell culture Combination complex complexes Concentration described divalent cation E. coli eliminating enzyme equine found function host proteins impair in vitro activity in vitro study include Increased Increasing Infected Influenza virus inhibit inhibited inhibitory effect Ionophore molecular nidovirus Nsp12 Nsp9 Pathogens plasma Poliovirus polymerases polyprotein polyproteins Proteolytic processing protocol provide purified RdRP RdRps reduced related Replication replication complex replicative Research reversed RNA RNA synthesis RNA viruses RNA-dependent RNA polymerase RTC SARS-coronavirus SARS-CoV target Transcription Transport variety Viral RNA virus Zinc Zn [DOI] 10.1371/journal.ppat.1001176 PMC 바로가기 [Article Type] Research Article