SARS-COV-2 recombinant Receptor-Binding-Domain (RBD) induces neutralizing antibodies against variant strains of SARS-CoV-2 and SARS-CoV-1SARS-COV-2 재조합 수용체 결합 도메인(RBD)은 SARS-CoV-2 및 SARS-CoV-1의 변이주에 대한 중화 항체를 유도합니다Article Published on 2021-09-242022-09-11 Journal: Vaccine [Category] MERS, SARS, 변종, 진단, [키워드] activate adjuvants alum antibody approved B.1.1.7 B.1.351 booster cellular immune responses COVID19 cross-neutralization etiological agent evade Evidence Formulation immune responses in vitro induce less MPLA neutralization Neutralizing antibodies neutralizing antibody protective immunity RBD SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 Spike RBD Spike protein Spread strain tested the spike protein Vaccine vaccine antigen variant variants virion VoC [DOI] 10.1016/j.vaccine.2021.08.081 PMC 바로가기 [Article Type] Article
Neutralizing Antibodies against SARS-CoV-2, Anti-Ad5 Antibodies, and Reactogenicity in Response to Ad5-nCoV (CanSino Biologics) Vaccine in Individuals with and without Prior SARS-CoV-2Article Published on 2021-09-202022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Ad5 Ad5-nCoV adverse effects age antibody antibody production booster booster dose clinical trial COVID-19 COVID-19 infection Effects Factor generate group IgG ELISA immunized immunosuppressive individual induce median natural infection Neutralizing antibodies neutralizing antibody Patient quantified reactogenicity recruited response SARS-CoV-2 surrogate Test vaccination Vaccine [DOI] 10.3390/vaccines9091047 PMC 바로가기 [Article Type] Article
Antibodies against SARS-CoV-2 Time Course in Patients and Vaccinated Subjects: An Evaluation of the Harmonization of Two Different MethodsArticle Published on 2021-09-182022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] anti-RBD antibody BAU booster chemiluminescence immunoassay collected Concentration Course decrease detectable eight ELISA evaluated Evidence first dose harmonization IgG immune response IMPROVE less method comparison onset of symptom Patient patients patients with COVID-19 reduced remained SARS-CoV-2 SARS-CoV-2 antibody response second dose second vaccination significant increase specimen subject subjects Symptoms the antibody time vaccination [DOI] 10.3390/diagnostics11091709 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of SARS-CoV-2 variant mRNA vaccine boosters in healthy adults: an interim analysis건강한 성인의 SARS-COV-2 변이체 mRNA 백신 부스터의 안전성 및 면역 원성 : 중간 분석Clinical Trial Published on 2021-09-152022-08-13 Journal: Nature Medicine [Category] MERS, SARS, 변종, 임상, 진단, [키워드] (Beta) addition assessment assessments B.1.351 B.1.617.2 Beta boost booster booster dose booster doses clinical COVID-19 vaccine COVID-19 vaccine mRNA-1273 Delta dose evaluate Exploratory analyses Exploratory analysis exploratory interim analysis Gamma group healthy immunogenicity include interim analysis mRNA mRNA vaccine mRNA-1273 mRNA-1273 booster mRNA-1273.211 multivalent mRNA-1273.211 neutralization neutralization titer neutralization titers Neutralizing antibodies neutralizing antibody Open-label open-label phase 2a study P.1 RNA vaccines Safe Safety SARS-CoV-2 variant SARS-CoV-2 variants significant increase single booster dose statistically susceptibility titers Trial trial participant undetectable Vaccine variant variant-modified booster variant-modified boosters variant-modified mRNAs variant-specific vaccines variants variants of interest VoC VOCs VOIs waned wild-type D614G wild-type D614G virus [DOI] 10.1038/s41591-021-01527-y PMC 바로가기 [Article Type] Clinical Trial
Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)Articles Published on 2021-09-112022-10-30 Journal: Lancet (London, England) [Category] COVID-19, [키워드] 95% CI Academy analyses antibodies antibody Antibody titre antibody titres AstraZeneca AZD1222 baseline boost booster ChAdOx1 nCoV-19 Chinese Clinical research Coalition Cohort Controlled trial Council country COVID-19 vaccine dose Efficacy ELISA Engineering enrolled extended interval finding first dose funding geometric mean titre IgG Immunity immunogenicity data induce Innovation IQR ISRCTN median Medical Science mononuclear cell network NIHR Oxford participant PBMC Peripheral blood persistence phase 2/3 prime-boost interval randomised controlled trial reactogenicity Registered remained Science second dose SFU significantly higher single dose South supply shortage T-cell Response T-cell responses T-cells responses the vaccine titre vaccination Vaccine Valley viral particle Volunteer [DOI] 10.1016/S0140-6736(21)01699-8 PMC 바로가기 [Article Type] Articles
Intradermal ChAdOx1 Vaccine Following Two CoronaVac Shots: A Case ReportCase Report Published on 2021-09-042022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] Alpha antibody booster booster dose cellular response ChAdOx1 ChAdOx1 vaccine ChAdOx1-S CoronaVac country COVID-19 vaccines declining dramatic increase Healthcare professional healthy Heterologous IgA IgG IgG level immune response Intradermal intradermal injections intramuscular intramuscular injections investigated lentiviral Local male neutralization titer neutralizing antibody PBMCs pseudovirus Reactions report SARS-CoV-2 vaccine SARS-CoV-2-specific T cell spike gene Spike protein T cell response total antibodies wild type [DOI] 10.3390/vaccines9090990 PMC 바로가기 [Article Type] Case Report
SARS-CoV-2 Serology Status Detected by Commercialized Platforms Distinguishes Previous Infection and Vaccination Adaptive Immune Responses상용화된 플랫폼에 의해 감지된 SARS-CoV-2 혈청학 상태는 이전 감염 및 예방 접종 적응 면역 반응을 구별합니다Article Published on 2021-09-012022-09-11 Journal: The journal of applied laboratory medicine [Category] SARS, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Adaptive immune response adaptive immune responses antibody booster Cohort commercial assays Coronavirus-2 correlated correlation COVID-19 death detect dose evaluated healthcare worker IgG immune response immune responses individual infected individuals Infection infective Infective dose initial median Moderna NAb NAbs natural infection neutralization titer neutralization titers Neutralizing Neutralizing antibodies neutralizing antibody Patient Pfizer platform positive pseudovirus PSV reactivity respiratory response Roche SARS-CoV-2 SARS-CoV-2 infected individuals SARS-CoV-2 NAb SARS-CoV-2 PCR SARS-CoV-2 pseudovirus serology Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus single dose status understanding utility vaccinated individual vaccinated individuals vaccination Vaccine Vaccines [DOI] 10.1093/jalm/jfab080 PMC 바로가기 [Article Type] Article
Initial SARS-CoV-2 vaccination response can predict booster response for BNT162b2 but not for AZD1222초기 SARS-CoV-2 백신 접종 반응은 BNT162b2에 대한 추가 반응을 예측할 수 있지만 AZD1222에 대해서는 예측할 수 없습니다Article Published on 2021-09-012022-09-12 Journal: International Journal of Infectious Diseases [Category] SARS, 진단, [키워드] acute respiratory syndrome addition age antibody antibody level Antibody Response AstraZeneca AZD1222 binding antibody unit BNT162b2 booster booster response Coronavirus-2 correlated dependent on determine Elecsy Final first dose Immunosuppressive medication Infection IQR of BNT162b2 Pfizer/BioNTech positive correlation predict quantified recipient response responses Roche SARS-CoV-2 SARS-CoV-2 S SARS-CoV-2 vaccination second dose serology the vaccine Vaccine [DOI] 10.1016/j.ijid.2021.07.063 PMC 바로가기 [Article Type] Article
Evaluation of Antibody Responses to COVID-19 Vaccines among Solid Tumor and Hematologic PatientsArticle Published on 2021-08-262022-10-31 Journal: Cancers [Category] COVID-19, [키워드] analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody Anti-SARS-CoV-2 S antibody production Antibody Response Antibody titer approaches booster Cancer patients Complete COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19-related complication COVID-19-related complications decrease evaluate hematologic higher risk immune response Mortality observation Patient patient cohort patients Protective public health response SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 S vaccine significantly higher simple Solid solid tumor Spike protein Support the SARS-CoV-2 Treatment Tumor university vaccination Vaccination strategy vulnerable patients while [DOI] 10.3390/cancers13174312 PMC 바로가기 [Article Type] Article
Immunological evaluation of an inactivated SARS-CoV-2 vaccine in rhesus macaquesResearch article Published on 2021-08-262022-10-05 Journal: Molecular Therapy [Category] 비임상, [키워드] acute respiratory syndrome Analysis Antibody Response booster coronavirus coronavirus disease COVID-19 effective elicited formaldehyde immune response immunization immunized immunological immunopathological damage inactivated Inactivated vaccine inactivation individual inhibiting viral replication macaque macaques mice Pathogenesis performed produced PROTECT Protective rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 vaccine T cell response tested Vaccine Vaccine development Viral antigen viral challenge [DOI] 10.1016/j.omtm.2021.08.005 [Article Type] Research article