A synthetic consensus anti–spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primatesArticle Published on 2015-09-042022-11-01 Journal: Science Translational Medicine [Category] Coronavirus, [키워드] acute respiratory syndrome antigen-specific neutralizing antibody antiviral therapy approved Arabian Peninsula cause caused cellular immunity characteristic Consensus coronavirus deaths disease DNA vaccine Europe exhibited increase in induce Infection lack Lineage macaque macaques MERS MERS coronavirus MERS spike protein MERS-CoV mice Middle East morbidity Mortality nosocomial pathogen Pneumonia Prevent protective immunity protective response Protein Radiographic respiratory syndrome coronavirus rhesus macaque route of infection SARS-CoV seroconverted syndrome The United States Transmission treat Vaccine viral challenge virus-neutralizing [DOI] 10.1126/scitranslmed.aac7462 PMC 바로가기 [Article Type] Article
Diversity of coronavirus in bats from Eastern ThailandShort Report Published on 2015-04-112022-10-28 Journal: Virology Journal [Category] Coronavirus, MERS, [키워드] alphacoronaviruses Analysis bat bats betacoronaviruses collected complex Consensus coronavirus coronavirus CoV CoVs Cynopterus detect Diversity Eastern effort Endemic fecal finding Genetic Hipposidero hosts human pathogen imperative indicate Lineage lineage B betacoronavirus Megaderma Middle East nine PCR primer Phylogenetic preserved reactive Rectal swabs Region reported reservoir respiratory RNA Sample SARS-CoV Scotophilus Seven specimen Surveillance Taphozous Thailand transported zoonotic [DOI] 10.1186/s12985-015-0289-1 PMC 바로가기 [Article Type] Short Report
Prevalence and Genetic Diversity Analysis of Human Coronavirus OC43 among Adult Patients with Acute Respiratory Infections in Beijing, 2012Research Article Published on 2014-07-022022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Acute respiratory infection addition Amino acid Analysis ARI assays Beijing circulating Cluster coding region collected Consensus described determine Diversity epidemiological Epidemiology Evidence genetic diversity HCoV-OC43 Human coronavirus human coronavirus OC43 Infection N gene nasopharyngeal swab sample OC43 occurred Partial Patient patients patients with ARI Phylogenetic Phylogenetic analysis polymerase chain Prevalence profile respiratory reverse transcription RT-PCR sequence sequenced strain the epidemic the patient unique [DOI] 10.1371/journal.pone.0100781 PMC 바로가기 [Article Type] Research Article
A highly conserved WDYPKCDRA epitope in the RNA directed RNA polymerase of human coronaviruses can be used as epitope-based universal vaccine designResearch Article Published on 2014-05-292022-10-27 Journal: BMC Bioinformatics [Category] Coronavirus, [키워드] 100% conserved Antigen approach can be used Consensus conserved coronavirus coronavirus coronavirus disease coronavirus strains epitope human coronavirus identify immunogenic in silico in vivo include Infection membrane MERS-CoV Multiple nucleocapsid outbreak peptide polyprotein predict Prevent prevention Protein Result RNA RNA directed RNA polymerase RNA polymerase RNA virus SARS-CoV sequence strain Strains Universal vaccine Vaccine Vaccine design virus [DOI] 10.1186/1471-2105-15-161 PMC 바로가기 [Article Type] Research Article
Genotypic and Functional Impact of HIV-1 Adaptation to Its Host Population during the North American Epidemic북미 전염병 동안 숙주 인구에 대한 HIV-1 적응의 유전형 및 기능적 영향Research Article Published on 2014-04-242022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulate adaptation analyzed Antiviral antiviral immunity assessment average Boston cellular immunity changes in characterized circulating codon Cohort Consensus consequence detectable enrolled Epidemic ERAS escape mutation Evolution exhibiting explain Frequency functional Gag greater HIV HIV-1 HLA Host immune immune escape mutation immune escape mutations Impact implication in vitro Increases individual information median medians Mutation New York North North America Patient persistence phenotypic Phylogeny polymorphism Polymorphisms Population Protective Protein reconstructed reduce remained replication capacity residue Result San Francisco selected sequence specimen Spread subsequent suggested Support the epidemic the median Transmission unlikely Viral viral fitness Viral proteins virus [DOI] 10.1371/journal.pgen.1004295 PMC 바로가기 [Article Type] Research Article
Distinct Immune Response in Two MERS-CoV-Infected Patients: Can We Go from Bench to Bedside?Research Article Published on 2014-02-142022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] absence adaptive Adaptive immune response Antigen presentation Antiviral approach BAL Bench Can Cell chemokine compared Consensus control patients coronavirus Critical cytokine decrease determine died different dsRNA early stage enzyme-linked immunosorbent highlight humans IFN IFNα IFNγ IL-12 IL-17 immune response impair in vitro Infected infected patient Infection initial intensive care involved mechanism MERS-CoV MERS-CoV infection Middle East National Occurrence outcome Patient polymerase chain promote respiratory response RNA robust secretion sera supernatant therapeutic approaches Treatment viral dsRNA viruses was performed were used World Health Organization [DOI] 10.1371/journal.pone.0088716 PMC 바로가기 [Article Type] Research Article
Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause RegionsHIV-1 및 프로모터-근위 일시 중지 영역에서 NELF-E RNA 결합 정의Research Article Published on 2014-01-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition analyzed association Author binding binding activity binding domain Biochemistry cellular claimed compared complex Consensus conserved contribute downstream Drosophila elongation elongation factor eukaryotic facilitate Factor functional Gene Genes Genome high affinity HIV-1 identify in addition to in vitro Interaction modulate molecular negative nuclear nucleotide nucleotides observé pause POLL promoter Protein protein coding gene protein coding genes Protein subunit Quantitative Recognition Region regulate regulated Regulatory required responsible RNA RNA Polymerase II RNA sequence RNA sequences sequence significant increase subunit Support targets thought transcribed Transcription transcription factor transcription factors transcription start site widespread [DOI] 10.1371/journal.pgen.1004090 PMC 바로가기 [Article Type] Research Article
ImmunoChip Study Implicates Antigen Presentation to T Cells in NarcolepsyImmunoChip 연구는 기면증에서 T 세포에 대한 항원 제시를 의미합니다Research Article Published on 2013-02-142022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] addition Alpha Antigen presentation antigen processing Author Autoimmune autoimmune and inflammatory diseases autoimmune attack Autoimmune disease Cathepsin H chromosome chromosome 6 class compared Consensus Control controls CTSH deficiency disease pathogenesis disease risk encoded protein encoded proteins environmental exposure European Gene Genes genome-wide significance genotyped genotyping high-density genotyping platform HLA HLA class II HLA DQB1*06:02 Human human leukocyte antigen hypocretin cells ImmunoChip immunological synapse implicated in addition to individual inflammatory disease Inflammatory diseases Interaction leukocyte Ligand loci mechanism Narcolepsy narcolepsy-hypocretin deficiency OX40L pathophysiology pathway post-infectious autoimmune presentation progression recent selective significantly study variant Support susceptibility T cell T cell receptor T cell response T cells the disease TNFSF4 TNFSF4/OX40L tumor necrosis tumor necrosis factor unique variant variants while [DOI] 10.1371/journal.pgen.1003270 PMC 바로가기 [Article Type] Research Article
Aerosol Generating Procedures and Risk of Transmission of Acute Respiratory Infections to Healthcare Workers: A Systematic ReviewResearch Article Published on 2012-04-262022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] Abstract Acute respiratory infection administration aerosol agency AGP ARI article articles Asia association body fluids Case-control Chest CINAHL clinical evidence Cochrane Library compared Consensus CRD criteria Defibrillation determine disagreement evaluated Evidence HCW HCWs Health Health care worker included increased risk Index Medicus insertion International Internet intubation LILACS manual ventilation multiple study non-invasive ventilation not significant Other outcome pathogen Patient procedure reported resolved respiratory retrospective cohort study review risk risk factor risk of transmission screened searched selected sputum suction tracheal Transmission Treatment university York [DOI] 10.1371/journal.pone.0035797 PMC 바로가기 [Article Type] Research Article
Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell DeterminantResearch Article Published on 2008-10-242022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] alteration amino acid substitution analysis antigen-specific T cell association Author CD8+ T cell changes in clinical disease complex Complex molecule conformation Consensus Critical CTL cytotoxic determinant Disease progression Diseases elicit Enhancing epitope escape expressed functional Hepatitis histocompatibility HIV immune response immune responses immunodominant Infected Local Major memory MHC class I mice molecular basis motif mouse hepatitis mutated Mutation natural infection occur pathogen peptide performed prevention PROTECT Protective recombinant residue response significantly higher stability Subdominant T cell T cell epitope T cell response tumor immunity Vaccine development viral infection virus virus wildtype [DOI] 10.1371/journal.ppat.1000186 PMC 바로가기 [Article Type] Research Article