inhibited
[대역어] None
[용어속성] Action
[용어속성] Action
Distinct Patterns of IFITM-Mediated Restriction of Filoviruses, SARS Coronavirus, and Influenza A Virus
Research Article
[키워드] Acidic
Author
bypasse
bypassed
cathepsin L
Cell
cellular
cellular tropism
circumvent
compared
Control
cytoplasm
described
did not reduce
Ebola
Ebola virus
Endocytic pathway
ENhance
example
Express
expression
Factors
filovirus
glycoprotein
highly pathogenic
IAV
IFITM
IFITM1
IFITM3
indicate
Infection
infectious
influenza A virus
inhibit
inhibited
innate immune system
interfere
late stage
less
limit
lysosomal
modulate
murine
observation
pathogenic viruses
pattern
plasma membrane
Protein
Proteins
pseudovirions
receptor
Replication
restrict
restriction
restriction factor
SARS Coronavirus
SARS-CoV
transmembrane
transmembrane protein
Treatment
viral replication
virion
virus
virus
viruses
[DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1001258 PMC 바로가기 [Article Type] Research Article
Zn 2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture
Research Article
[키워드] activity
Antiviral
arteritis
arterivirus
Author
binding
block
both viruses
catalyzed
Cell
Cell culture
Combination
complex
Complexes
Concentration
described
divalent cation
E. coli
eliminating
enzyme
equine
found
function
host proteins
impair
in vitro activity
in vitro study
include
Increased
Increasing
Infected
Influenza virus
inhibit
inhibited
inhibitory effect
Ionophore
molecular
nidovirus
nidovirus
Nsp12
Nsp9
Pathogens
plasma
Poliovirus
polymerases
polyprotein
polyproteins
Proteolytic processing
protocol
provide
purified
RdRP
RdRps
reduced
related
Replication
replication complex
replicative
Research
reversed
RNA
RNA synthesis
RNA viruses
RNA-dependent RNA polymerase
RTC
SARS-coronavirus
SARS-CoV
target
Transcription
Transport
variety
Viral RNA
virus
virus
Zinc
Zn
[DOI] 10.1371/journal.ppat.1001176 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1001176 PMC 바로가기 [Article Type] Research Article
Identification of NCAM that interacts with the PHE-CoV spike protein
Research
[키워드] adhesion
antibody
antiviral therapies
association
binding
blocked
cDNA library
Cell
cells
cellular
cellular molecule
coronavirus
Critical
double-stranded
found
identification
Infection
inhibited
interact
Interaction
molecule
Neural
Protein
required
Result
S glycoproteins
S protein
screened
siRNA
Spike protein
T7
target
target cells
viral life cycle
virus infection
[DOI] 10.1186/1743-422X-7-254 PMC 바로가기 [Article Type] Research
[DOI] 10.1186/1743-422X-7-254 PMC 바로가기 [Article Type] Research
Structure and Inhibition of the SARS Coronavirus Envelope Protein Ion Channel
Research Article
[키워드] 2003
acute respiratory syndrome
affecting
alteration
Anti-viral drugs
antiviral strategy
Author
binding site
C-terminal
Cell
channel
characterized
common cold
coronavirus
coronavirus
coronavirus protein
described
determined
distribution
drug design
E protein
embryonic kidney
envelope
envelope protein
event
expressed
expressing
feature
form
found
full length
HEK-293
Human
humans
in vitro
inactivation
infect
inhibited
inhibition
Ion
lethal disease
mammalian cell
mammals
membrane
Mild
morphology
N-terminal
NMR
pandemic
Pathogenesis
pharmacological target
platform
produced
Protein
Proteins
provide
reduced
reported
responsible
SARS-CoV
SARS-CoV E
shown
significantly
Structure
supported
transmembrane domain
Validity
variety
viral envelope
viral pathogen
viral replication
virion
virus
viruses
[DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000511 PMC 바로가기 [Article Type] Research Article
Mouse Hepatitis Coronavirus RNA Replication Depends on GBF1-Mediated ARF1 Activation
Research Article
[키워드] Activation
ADP-ribosylation
Analysis
ARF
ARF1
association
Author
cells
cellular
cellular pathway
characteristic
complex
connection
coronavirus
coronavirus
Coronavirus replication
Critical
demonstrated
dominant-negative
downstream
Endoplasmic reticulum
Express
expression
Factors
GBF1
GTPase
GTPases
guanine
Host
Human
induce
infected cell
Infection
inhibited
inhibiting
interfere
involved
knockdown
MDCK cells
membrane
MHV
Microscopy
mouse
mouse hepatitis
mutant
nucleotide
observation
provide
Quantitative
reduced
Replication
replication complex
required
RNA
RNA virus
secretory pathway
significantly
siRNA
siRNAs
structures
target
vesicles
viruses
[DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1371/journal.ppat.1000088 PMC 바로가기 [Article Type] Research Article
Inhibition of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infectivity by peptides analogous to the viral spike protein
Article
[키워드] affected
Anti-viral
antiviral activity
Asia
Atypical
cell cytotoxicity
Class I viral fusion protein
Concentration
concentrations
coronavirus
CoV
domain
dose-dependent
Effect
Europe
fusion peptide
fusion protein
glycoprotein
heptad repeat
hydrophobicity
IC50
identify
inhibited
inhibition
inhibitor
membrane
membrane fusion
MHV
murine hepatitis virus
N-terminus
North America
peptide
Peptide inhibitor
Pneumonia
provide
recent
Receptor binding
Region
regions
responsible
S2 subunit
SARS-CoV
severe
Severe acute respiratory syndrome-associated coronavirus
six-helix bundle
tested
the S protein
viral infectivity
viral spike
viral spike protein
was used
white
[DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article
[DOI] 10.1016/j.virusres.2006.03.001 PMC 바로가기 [Article Type] Article
A human in vitro model system for investigating genome-wide host responses to SARS coronavirus infection
Research Article
[키워드] 24 hours
activated
acute respiratory syndrome
Analysis
Antibody binding
array
assay
Blood
cell activation
change
chemokine
clinical feature
Coagulation
coronavirus
CoV
cytokine production
described
disease pathology
distress
donors
examined
Gene Expression
healthy donor
high-density
host response
IL17
IL8
immune response
in vitro
indicated
infecting
Infection
infiltration
inhibited
inoculated
interstitial
interstitial inflammation
lung trafficking
lymphopenia
mechanism
molecular basis
monocyte-macrophage
mononuclear cell
Pathogenesis
pathology
pathway
PBMC
PBMCs
Peripheral blood
provide
Quantitative assays
Result
SARS Coronavirus
SARS patient
SARS-CoV
Signaling
specific antibody
the disease
TLR9
upregulation
viral replication
viral replication kinetics
[DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1186/1471-2334-4-34 PMC 바로가기 [Article Type] Research Article
Coronaviridae and SARS-associated Coronavirus Strain HSR1
Research
[키워드] 2003
addition
affected
Analysis
biologic
Cell
cell membrane
Characteristics
Coronaviridae
coronavirus
CoV
determined
Evidence
Features
form
full-length
generate
Genetic
genomic
hotel
Infected
Infection
inhibited
Isolation
Italian
Italy
molecular
New coronavirus
outbreak
Patient
Plaque assay
Real-time PCR
required
SARS-coronavirus
SARS-CoV
sequence
specimen
sputum
strain
TaqMan
the patient
Vero Cell
Vesicle
viral genome
viral genome sequence
virion
[DOI] 10.3201/eid1003.030683 PMC 바로가기 [Article Type] Research
[DOI] 10.3201/eid1003.030683 PMC 바로가기 [Article Type] Research