Rationale and design of the “Tocilizumab in patients with moderate to severe COVID-19: an open-label multicentre randomized controlled” trial (TOCIBRAS)"중등도에서 중증의 COVID-19 환자에 대한 토실리주맙: 공개 라벨 다기관 무작위 통제" 시험(TOCIBRAS)의 근거 및 설계Original Article Published on 2020-01-012022-08-13 Journal: Revista Brasileira de Terapia Intensiva [Category] 임상, [키워드] 7-point ordinal scale adjusted age and sex alleviate Analysis anti-inflammatory therapies Anti-inflammatory therapy applied approved Brazil C reactive protein Clinical outcome clinical outcomes clinical status combating consequence Coronavírus COVID-19 COVID-19 patient COVID-19 patients criteria D-dimer disease severity dissemination enrolment ethical committee Ethics ferritin IMPROVE inflammatory cascade inflammatory mediator Inflammatory response inhibiting institutional review board institutional review boards interleukin-6 International Lactate lactate dehydrogenase limit Local mediator moderate to severe multicentre National Odds ratio Open-label ordinal logistic regression Ordinal Scale outcome patients patients with COVID-19 patients with moderate primary endpoint Pro-inflammatory marker pro-inflammatory markers protocol Randomized Randomized controlled trial rationale required severe COVID-19 severity Standard of care Stratification Study protocol the disease The TOCIBRAS protocol TOCIBRAS Tocilizumab Tocilizumabe Trial trial testing variable [DOI] 10.5935/0103-507X.20200060 PMC 바로가기 [Article Type] Original Article
Vascular microthrombosis associated with increased interleukin-6. A severe acute respiratory distress syndrome in COVID-19 patients treated with tocilizumabArticle Published on 2020-01-012023-07-05 Journal: Advances in respiratory medicine [Category] SARS, [키워드] COVID-19 interleukin-6 Tocilizumab [DOI] 10.5603/ARM.a2020.0123
The immune response of young turkeys to haemorrhagic enteritis virus infection at different levels and sources of methionine in the dietResearch Article Published on 2019-11-012022-10-28 Journal: BMC veterinary research [Category] Coronavirus, [키워드] added addition Administered age Amino acid analysed appear assigned B cell Blood CD25 CD4 CD8 Cell cell subpopulation decrease described diagnosed disease dose evaluate Haemorrhagic enteritis virus Humoral immunity hydroxy IgA levels IgM IL-6 IL-6 level immune function immune response impair increase in Infection interleukin-6 isolate metabolic pathway methionine moderate not differ parameter parameters pathogenic percentage plasma Poland positive receiving regulate Result secondary bacterial infection severe immunosuppression significant decrease significantly spleen strain tonsil Treatment Turkey Turkeys uninfected USA virus virus infection [DOI] 10.1186/s12917-019-2138-8 PMC 바로가기 [Article Type] Research Article
Cutaneous plasmacytosis and multinucleate cell angiohistiocytoma-like lesion in a patient with hepatitis B: A fortuitous triad?Case Reports Published on 2019-09-012023-06-18 Journal: Journal of cutaneous pathology [Category] B형 간염, [키워드] HBe antigen hepatitis B interleukin-6 multinucleate cell angiohistiocytoma Plasma cells plasmacytosis reactive vascular cutaneous processes Seroconversion [DOI] 10.1111/cup.13491 [Article Type] Case Reports
[Correlation between interleukin-6 single nucleotide polymorphism and the occurrence and prognosis of hepatitis B virus-associated acute-on-chronic liver failure]Article Published on 2019-04-202023-06-16 Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese [Category] B형 간염, [키워드] Acute-on-chronic liver failure Hepatitis B virus interleukin-6 Single nucleotide polymorphism [DOI] 10.3760/cma.j.issn.1007-3418.2019.04.003
Off-label use of tocilizumab to treat non-juvenile idiopathic arthritis in pediatric rheumatic patients: a literature reviewReview Published on 2018-12-142024-09-02 Journal: Pediatric Rheumatology Online Journal [Category] 대상포진, [키워드] Autoimmune disease interleukin-6 Takayasu’s arteritis Tocilizumab [DOI] 10.1186/s12969-018-0296-z PMC 바로가기 [Article Type] Review
Autophagy Quantification and STAT3 Expression in a Human Skin Organ Culture Model for Innate Immunity to Herpes ZosterOriginal Research Published on 2018-12-052024-09-02 Journal: Frontiers in Microbiology [Category] 대상포진, [키워드] Atg5 autophagosome herpes simplex virus HSV ICP34.5 Imaris software interleukin-6 Pseudorabies virus Varicella-Zoster Virus [DOI] 10.3389/fmicb.2018.02935 PMC 바로가기 [Article Type] Original Research
Porphyromonas gingivalis induced inflammatory responses and promoted apoptosis in lung epithelial cells infected with H1N1 via the Bcl-2/Bax/Caspase-3 signaling pathwayArticle Published on 2018-07-072023-06-23 Journal: Molecular medicine reports [Category] 신종인플루엔자, [키워드] Porphyromonas gingivalis influenza A virus subtype H1N1 interleukin-1β interleukin-6 Lung epithelial cells nitric oxide nitric oxide synthase tumor necrosis factor-α [DOI] 10.3892/mmr.2018.8983 PMC 바로가기 [Article Type] Article
Sirukumab in rheumatoid arthritis refractory to sulfasalazine or methotrexate: a randomized phase 3 safety and efficacy study in Japanese patientsResearch Article Published on 2018-03-072023-08-29 Journal: Arthritis Research & Therapy [Category] E형 간염, [키워드] Biologicals Disease-modifying anti-rheumatic drugs interleukin-6 rheumatoid arthritis Sirukumab [DOI] 10.1186/s13075-018-1536-9 PMC 바로가기 [Article Type] Research Article
HBV Facilitated Hepatocellular Carcinoma Cells Proliferation by Up-Regulating Angiogenin Expression Through IL-6Article Published on 2018-01-012023-06-18 Journal: Cellular physiology and biochemistry : international journal of [Category] B형 간염, [키워드] Angiogenin Hepatitis B virus Hepatocellular carcinoma interleukin-6 [DOI] 10.1159/000488614