Impact of COVID-19 on the lives and mental health of children and adolescentsArticle Published on 2022-10-182022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] Adolescent affected age Anxiety children Complete concerning COVID-19 COVID-19 pandemic Digital disease European expand GAD Generalized greater Health help higher education Impact introduced Local lockdown major depressive disorder mental health mental health issue mental health service outcomes pandemic physical distancing Prevalence questionnaire reflected significantly social life. spread of COVID-19 Stress student survey therapeutic union [DOI] 10.3389/fpubh.2022.925213 PMC 바로가기
Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray ScreeningArticle Published on 2022-10-182022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제, [키워드] affinity Antiviral antiviral drug applicability assays atomic resolution caused consequence Consequences conserved coronavirus CoV COVID-19 cross-binding effects Degradation drug design effective Efficiency expression fragment-based X-ray screening functional Health Host host mRNA IFN infection rate inhibitor interferon ligands limitation MERS coronaviruses mortality rate N-terminal domain non-structural protein non-structural protein 1 outbreak pandemic Pathways Protein provide Replication respiratory Revealed Safe SARS-CoV-2 Screening Site starting point Structure-based drug design unique vaccination Vaccines variety virulence virus X-ray X-ray crystallography [DOI] 10.3390/ijms232012448 PMC 바로가기
Derivation, Functionalization of (S)-Goniothalamin from Goniothalamus wightii and Their Derivative Targets SARS-CoV-2 MPro, SPro, and RdRp: A Pharmacological PerspectiveArticle Published on 2022-10-172022-11-15 Journal: Molecules [Category] COVID19(2023년), SARS, 치료제, [키워드] (S)-Goniothalamin Anti-viral anticancer antioxidant antiviral properties antiviral property approach characterization complex Compound coronavirus COVID-19 derivation derivative disease drug examined LC-MS molecular molecular dynamics MPro NMR pandemic performed phytochemical platform Pro RdRP required Research SARS-CoV-2 SARS-COV-2 infection Simulation study spike glycoprotein target target protein threat [DOI] 10.3390/molecules27206962 PMC 바로가기
Learning from the COVID-19 pandemic for future epidemics and pandemics preparedness and response in Guinea: Findings from a scoping reviewArticle Published on 2022-10-172022-11-16 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 변종, [키워드] activities Analysis anticipated applied boost conducted counterproductive country COVID-19 COVID-19 pandemic database distress Epidemic Epidemics epidemiological finding FIVE generate globe Guinea health system health system preparedness and response implementation IMPROVE information learning measure Measures mechanism media National Novel coronavirus outbreak pandemic Pandemics policy decisions provide Research Resilience responses SARS-CoV-2 These data triggered vaccination variant [DOI] 10.3389/fpubh.2022.879850 PMC 바로가기
Kinetics of Drug Molecule Interactions with a Newly Developed Nano-Gold-Modified Spike Protein Electrochemical Receptor SensorArticle Published on 2022-10-172022-11-15 Journal: Biosensors [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] amplification antiviral drug Chloroquine compounds Concentration correlated COVID-19 Detection sensitivity Developed docking drug drug target drugs electrochemical receptor biosensor exhibit Gln group Hydrogen bond Hydroxychloroquine Interaction investigated kinetic Kinetics limit of detection linear linkage allosterism molecule pandemic Protein provide receptor reported Research residue SARS-CoV-2 sensor Seven spike Spike protein the SARS-CoV-2 the spike protein Treatment was used WHO World Health Organization [DOI] 10.3390/bios12100888 PMC 바로가기
Point-of-care detection of SARS-CoV-2 antigen among symptomatic vs. asymptomatic persons: Testing for COVID-19 vs. infectivityArticle Published on 2022-10-172022-11-15 Journal: Frontiers in Public Health [Category] COVID19(2023년), SARS, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome Ag-RDT Antigen Asymptomatic Buenos Aires Care caused Concordance Contact coronavirus disease Coronavirus-2 COVID-19 COVID-19 patient detect diagnose diagnostic evaluate false-negative hypothetical identify individual Infectious virus Isolation pandemic Participants PCR point-of-care positive public health qRT-PCR rapid antigen testing real-time RT-PCR SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 RNA SARS-CoV-2 testing subjects Surveillance symptomatic t -value Testing threshold Transmission utility viral kinetics was obtained [DOI] 10.3389/fpubh.2022.995249 PMC 바로가기
Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virusArticle Published on 2022-10-172022-11-15 Journal: Signal Transduction and Targeted Therapy [Category] COVID19(2023년), SARS, 치료제, [키워드] Activation administration antiviral target cell injury Combination COVID-19 Critical Cytokine storm dependent on drugs facilitate FFA FFAs free fatty acid Host humans IAV Infection influenza A virus inhibitor inhibitors investigated late stage LDs limit Lipid lipid droplet lipolytic lung lung lesion Malnutrition membrane transporter mice mitigate Mortality outbreak pandemic patients pharmacological Proinflammatory cytokine PROTECT reduce Replication replication of SARS-CoV-2 rescued RNA RNA virus SARS-CoV-2 SARS-CoV-2-infected hamsters significantly suppressed therapeutic target Treatment viral infections virus virus-infected cell [DOI] 10.1038/s41392-022-01223-4 PMC 바로가기
Editorial: Diagnosis of zoonoses: Relevance of BSL3 and BSL4 facilitiesEditorial Published on 2022-10-172023-06-22 Journal: Frontiers in Cellular and Infection Microbiology [Category] 조류인플루엔자, [키워드] biosafety biosecurity BLS 3 and BLS 4 laboratories DURC pandemic [DOI] 10.3389/fcimb.2022.1052082 PMC 바로가기 [Article Type] Editorial
Omicron Severe Acute Respiratory Syndrome Coronavirus 2 Neutralization by Immunoglobulin Preparations Manufactured From Plasma Collected in the United States and EuropeArticle Published on 2022-10-172022-11-15 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome antibody collected coronavirus coronavirus 2 coronavirus disease COVID-19 Donor Europe European Immunoglobulin Infection intravenous Intravenous immunoglobulin less neutralization Neutralizing Neutralizing antibodies new virus omicron pandemic plasma preparation Primary Immunodeficiency Prophylaxis proportion raising respiratory SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antibody potency the United State union United State vaccination variant virus [DOI] 10.1093/infdis/jiac358 PMC 바로가기
Spectral and theoretical study of SARS-CoV-2 ORF10 protein interaction with endogenous and exogenous macroheterocyclic compoundsSARS-CoV-2 ORF10 단백질과 내인성 및 외인성 거대 이종고리 화합물 상호작용에 대한 스펙트럼 및 이론 연구Article Published on 2022-10-152022-09-11 Journal: Spectrochimica acta. Part A, Molecular and biomole [Category] COVID19(2023년), SARS, 치료제, [키워드] Accessory accessory protein accessory proteins Alpha Antiviral approved bind carried caused cells Chlorin choice complexes Compound coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 criteria drug effective drug effective drugs energy Escherichia coli expressed Features form health problem highest affinity Host immune response in silico infected patient infected patients inhibitor inhibitory initial Interaction macrocycle matter modulate molecular docking MOST ORF10 ORF10 protein Orientation pandemic Pathogenesis Porphyrin Pragmatic precedence Protein protoporphyrin public health recommendation resource SARS-CoV-2 SARS-CoV-2 accessory proteins SARS-CoV-2 coronavirus silico studies Spectral Spectroscopy Spectroscopy. Spread Stage suggested Taking the disease the SARS-CoV-2 Treatment treatment of COVID-19 virucidal virus [DOI] 10.1016/j.saa.2022.121403 PMC 바로가기 [Article Type] Article