Role of Porcine Aminopeptidase N and Sialic Acids in Porcine Coronavirus Infections in Primary Porcine EnterocytesArticle Published on 2020-04-052022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] acid aminopeptidase aminopeptidase N APN cells cellular cellular receptor Coronavirus infections Coronaviruses correlated determinant Efficiency Enterocyte enterocytes epidemic diarrhea expression gastroenteritis had no higher infectivity Infection Miller PEDV porcine coronavirus porcine epidemic diarrhea virus (PEDV) positive positive cell receptor replicated reported role Seven sialic acid sialic acids significant increase significantly susceptibility TGEV Transmissible gastroenteritis virus (TGEV) Treatment virus [DOI] 10.3390/v12040402 PMC 바로가기 [Article Type] Article
An Epidemiological Study on COVID-19: A Rapidly Spreading DiseaseMiscellaneous Published on 2020-03-182022-10-31 Journal: Cureus [Category] COVID-19, [키워드] calculated caused China conducted coronavirus COVID-19 COVID-19 case COVID-19 situation cured death deaths Epidemiology Government greater Healthcare system help highest IMPROVE incidence incidence rate Infectious disease Iran Italy measure Novel coronavirus novel coronavirus disease outbreak outcomes percentage public health crisis quarantine reached Regulation Research Result screened severity significance level significant decrease significant increase significantly social isolation Spread spreading subsequent the disease therapeutic virus World Health Organization [DOI] 10.7759/cureus.7313 PMC 바로가기 [Article Type] Miscellaneous
A cluster randomized controlled trial to increase the availability and acceptability of voluntary medical male circumcision in Zambia: The Spear and Shield Project잠비아에서 자발적인 의료 남성 할례의 가용성과 수용 가능성을 높이기 위한 클러스터 무작위 대조 시험: The Spear and Shield ProjectArticle Published on 2015-06-172022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] 95% CI adjusted odds ratio adverse event adverse events assigned baseline Care center Cluster community health Community health centers conditions conducted Control Controlled trial counseling death expressed female finding funding Health Health care HIV HIV infection HIV prevention Intervention likelihood male men MOST Odds ratio participant Participants Participation Patient performed post-intervention Prevalence prevention programs Primary outcome randomization Randomized controlled trial Randomly reported Result Shield significant increase Spear statistician stratified study participation supply Support tested Trial registration [DOI] 10.1016/S2352-3018(15)00042-9 PMC 바로가기 [Article Type] Article
Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trialHIV-1에 감염된 건강한 성인에서 후보 결핵 백신 MVA85A의 안전성, 면역원성 및 효능: 무작위, 위약 대조, 2상 시험Articles Published on 2015-03-012022-09-06 Journal: The Lancet. Respiratory Medicine [Category] Communicable Disease, [키워드] 1:1 95% CI absence active tuberculosis adverse event Antigen antigen 85A antigen 85A-specific T-cell response antiretroviral Antiretroviral therapy assigned assist baseline baseline CD4 block blocks booster Cape CD4 count CD4 counts Cell clinical defined detect detectable Developing disease double-blind effective Efficacy eligible Eligible participants enrolled enrolment European Evidence evidence of expressing finding first vaccination foundation funding gold greater Group allocation had no healthy HIV-1 HIV-1 infection immunogenic immunogenicity include increased risk Infection injection intradermal injections investigators isoniazid isoniazid prophylaxis Laboratory latent tuberculosis latent tuberculosis infection M tuberculosis Measures Melinda Gate Melinda Gates modified vaccinia virus MVA85A Mycobacterium tuberculosis nine no evidence of Nurses occurred outcome participant partnership peaked per-protocol analysis per-protocol population Phase 2 phase 2 trial Placebo placebo group placebo-controlled positive Potential Prophylaxis protocol QuantiFERON QuantiFERON-TB Gold In-Tube randomisation randomised Randomly receive receiving Registered reported Safe Safety safety analysis second vaccination secondary Secondary outcomes sequence Serious Adverse Event Serious Adverse Events significant increase South Africa stratified subset T-cell Response the placebo group therapy town Treatment Trial Tuberculosis tuberculosis disease tuberculosis vaccine undetectable vaccination Vaccine vaccine efficacy vaccine-induced immune response Viral Viral load Wellcome Trust were assessed [DOI] 10.1016/S2213-2600(15)00037-5 PMC 바로가기 [Article Type] Articles
Effects of Spirulina platensis supplementation on lipid profile in HIV–infected antiretroviral naïve patients in Yaounde – Cameroon: a randomized trial study야운데 - 카메룬에서 HIV에 감염된 항레트로바이러스 경험이 없는 환자의 지질 프로필에 대한 스피루리나 플라텐시스 보충제의 효과: 무작위 시험 연구Research Published on 2014-12-132022-09-06 Journal: Lipids in Health and Disease [Category] Communicable Disease, [키워드] abnormality age alteration antiretroviral Atherosclerosis average average age balanced diet baseline BMI body fat body mass body mass index cardiovascular cardiovascular diseases cardiovascular dysfunction cardiovascular risk factors CD4 cholesterol conducted contributing to CVD defined determine disease dyslipidemia Effect Factor fat distribution female Food Intake HDL-C HDL-cholesterol HIV HIV+ antiretroviral naïve include infections Inflammation insulin insulin resistance LDL-C LDL-cholesterol lipid profile Local local food majority metabolic syndrome multicentre naïve participant Patient patients public health Quantitative Randomized randomized trial recruited reported Result screened significant decrease significant increase significantly single-blind Spirulina platensis syndrome the patient Total cholesterol Triglyceride triglycerides variable weight were assessed with HIV [DOI] 10.1186/1476-511X-13-191 PMC 바로가기 [Article Type] Research
Depletion of Alveolar Macrophages Ameliorates Virus-Induced Disease following a Pulmonary Coronavirus InfectionResearch Article Published on 2014-03-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Adaptive immune response addition Administered airway airways alveolar macrophage CD4 CD4 T cell CD8 T cell coronavirus Coronavirus infection Critical Depletion disease evaluated Frequency Hepatitis Human Infection Liposome lung lung tissue mice Mild modulating morbidity and mortality mouse Pathogenesis pulmonary Respiratory disease shown significant increase subsequent susceptible Treg virus [DOI] 10.1371/journal.pone.0090720 PMC 바로가기 [Article Type] Research Article
Defining NELF-E RNA Binding in HIV-1 and Promoter-Proximal Pause RegionsHIV-1 및 프로모터-근위 일시 중지 영역에서 NELF-E RNA 결합 정의Research Article Published on 2014-01-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] a major addition analyzed association Author binding binding activity binding domain Biochemistry cellular claimed compared complex Consensus conserved contribute downstream Drosophila elongation elongation factor eukaryotic facilitate Factor functional Gene Genes Genome high affinity HIV-1 identify in addition to in vitro Interaction modulate molecular negative nuclear nucleotide nucleotides observé pause POLL promoter Protein protein coding gene protein coding genes Protein subunit Quantitative Recognition Region regulate regulated Regulatory required responsible RNA RNA Polymerase II RNA sequence RNA sequences sequence significant increase subunit Support targets thought transcribed Transcription transcription factor transcription factors transcription start site widespread [DOI] 10.1371/journal.pgen.1004090 PMC 바로가기 [Article Type] Research Article