A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoVSARS-CoV-2 및 SARS-CoV의 수용체 결합 도메인에서 고도로 보존된 비밀 에피토프Report Published on 2020-05-082022-09-14 Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 진단, 치료제, [키워드] antibody Antibody Response antigenicity bind binding binding epitope caused competent complex conserved convalescent convalescent SARS patient coronavirus disease COVID-19 CR3022 cross-reactive distal elicit epitope host cell molecular neutralizing antibody outbreak pandemic Patient Protein RBD receptor Receptor binding domain receptor binding site receptors SARS-CoV SARS-CoV-2 Science spike Spike protein target targeting the receptor-binding domain the SARS-CoV-2 trimeric S protein trimeric spike Vaccine design viral spike virus [DOI] 10.1126/science.abb7269 PMC 바로가기 [Article Type] Report
Mucosal Immune Response to Feline Enteric Coronavirus InfectionArticle Published on 2019-09-272022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] abnormality biopsy caused collected Colon Control convalescent coronavirus enteric expression fatal disease fecal Fecal sample feline enteric coronavirus Feline infectious peritonitis groups histologic humoral IFNγ IgG Infection inflammatory state investigated lymphocyte subpopulation mucosa mucosal mucosal IgA response mucosal immune mucosal immunity mutant virus organ pathogenic Perturbation phenotype proliferation response Result Significant suggested T cell three groups virus virus clearance [DOI] 10.3390/v11100906 PMC 바로가기 [Article Type] Article
A review of candidate therapies for Middle East respiratory syndrome from a molecular perspectiveReview Published on 2017-09-302022-10-29 Journal: Journal of Medical Microbiology [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome Antibiotics antiviral peptide camostat cathepsin L clinical trials Combination Controlled clinical trial convalescent convalescent plasma Corticosteroids current therapy DPP4 East effective furin protease GLS-5300 glycopeptide antibiotic high mortality rate host proteases include inhibitor interferon interferons laboratory-confirmed Lopinavir Lopinavir–ritonavir M(pro) Medline database MERS-CoV Middle East molecular monoclonal antibodies mortality rate Mutation pandemic Perspective PL(pro) potential therapy protease required respiratory syndrome coronavirus ribavirin S protein SARS-CoV searched subject syndrome Therapies therapy TMPRSS2 Transmissibility urgency Vaccine vaccine candidates Variation viral S protein [DOI] 10.1099/jmm.0.000565 PMC 바로가기 [Article Type] Review
Feasibility of a randomized controlled trial to assess treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in Saudi Arabia: a survey of physiciansResearch Article Published on 2016-07-122022-10-28 Journal: BMC Anesthesiology [Category] Coronavirus, MERS, [키워드] Blood Care clinical trial convalescent convalescent plasma Convalescent plasma therapy coronavirus Critical care Critically ill determine diagnose domain feasibility high mortality rate ICU ICUs include indicated Infection involved ISARIC Kingdom Laboratory majority MERS-CoV MERS-CoV-infected patient Middle East Middle East respiratory syndrome coronavirus (MERS-CoV) MOST participated patients physician Physicians Placebo questionnaire Randomized controlled trial Randomized controlled trials RCT RCTs recovered patients reported Research respiratory respiratory pathogen responsible Result Saudi Arabia specific treatment supplementary material Treatment while [DOI] 10.1186/s12871-016-0198-x PMC 바로가기 [Article Type] Research Article
Logistical feasibility and potential benefits of a population-wide passive immunotherapy program during an influenza pandemicArticle Published on 2012-05-062023-06-09 Journal: Influenza and Other Respiratory Viruses [Category] 신종인플루엔자, [키워드] convalescent Influenza pandemic plasma PMC 바로가기 [Article Type] Article
Duration of Antibody Responses after Severe Acute Respiratory SyndromeDispatch Published on 2007-10-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, MERS, [키워드] acute respiratory syndrome antibodies antibody average convalescent dispatch Duration Immunoglobulin initial longitudinal study occurred Patient reduction Reinfection respiratory response SARS SARS patient severe susceptible [DOI] 10.3201/eid1310.070576 PMC 바로가기 [Article Type] Dispatch